ID GP146_HUMAN Reviewed; 333 AA. AC Q96CH1; Q86SP5; DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 22-APR-2020, entry version 129. DE RecName: Full=Probable G-protein coupled receptor 146; DE AltName: Full=G-protein coupled receptor PGR8; GN Name=GPR146; Synonyms=PGR8; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 60-210. RX PubMed=12679517; DOI=10.1073/pnas.0230374100; RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., RA Bergmann J.E., Gaitanaris G.A.; RT "The G protein-coupled receptor repertoires of human and mouse."; RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC014241; AAH14241.1; -; mRNA. DR EMBL; AY255535; AAO85047.1; -; mRNA. DR CCDS; CCDS5321.1; -. DR RefSeq; NP_001290402.1; NM_001303473.1. DR RefSeq; NP_001290403.1; NM_001303474.1. DR RefSeq; NP_612454.1; NM_138445.3. DR RefSeq; XP_005249670.1; XM_005249613.2. DR RefSeq; XP_006715706.1; XM_006715643.2. DR IntAct; Q96CH1; 2. DR MINT; Q96CH1; -. DR STRING; 9606.ENSP00000380283; -. DR iPTMnet; Q96CH1; -. DR PhosphoSitePlus; Q96CH1; -. DR BioMuta; GPR146; -. DR DMDM; 67461068; -. DR jPOST; Q96CH1; -. DR PaxDb; Q96CH1; -. DR PeptideAtlas; Q96CH1; -. DR PRIDE; Q96CH1; -. DR ProteomicsDB; 76188; -. DR Antibodypedia; 10880; 278 antibodies. DR DNASU; 115330; -. DR Ensembl; ENST00000397095; ENSP00000380283; ENSG00000164849. DR Ensembl; ENST00000444847; ENSP00000410743; ENSG00000164849. DR GeneID; 115330; -. DR KEGG; hsa:115330; -. DR UCSC; uc003sjx.5; human. DR CTD; 115330; -. DR DisGeNET; 115330; -. DR GeneCards; GPR146; -. DR HGNC; HGNC:21718; GPR146. DR HPA; ENSG00000164849; Low tissue specificity. DR neXtProt; NX_Q96CH1; -. DR OpenTargets; ENSG00000164849; -. DR PharmGKB; PA134958088; -. DR eggNOG; ENOG410ITRV; Eukaryota. DR eggNOG; ENOG410YXU4; LUCA. DR GeneTree; ENSGT00950000182719; -. DR InParanoid; Q96CH1; -. DR KO; K08431; -. DR OMA; PRTYMSS; -. DR OrthoDB; 662615at2759; -. DR PhylomeDB; Q96CH1; -. DR TreeFam; TF333506; -. DR ChiTaRS; GPR146; human. DR GeneWiki; GPR146; -. DR GenomeRNAi; 115330; -. DR Pharos; Q96CH1; Tdark. DR PRO; PR:Q96CH1; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q96CH1; protein. DR Bgee; ENSG00000164849; Expressed in subcutaneous adipose tissue and 161 other tissues. DR ExpressionAtlas; Q96CH1; baseline and differential. DR Genevisible; Q96CH1; HS. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR037487; GPR146. DR PANTHER; PTHR24226:SF3; PTHR24226:SF3; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; KW Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..333 FT /note="Probable G-protein coupled receptor 146" FT /id="PRO_0000069622" FT TOPO_DOM 1..30 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 31..51 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 52..65 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 66..86 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 87..102 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 103..123 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 124..146 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 147..167 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 168..189 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 190..210 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 211..233 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 234..254 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 255..279 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 280..300 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 301..333 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 8 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" SQ SEQUENCE 333 AA; 36580 MW; BB8D6505A6C2D9F4 CRC64; MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL ANLHSKASMT MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE VHVALQIPFN VSSLVAMYST ALLSLDHYIE RALPRTYMAS VYNTRHVCGF VWGGALLTSF SSLLFYICSH VSTRALECAK MQNAEAADAT LVFIGYVVPA LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC TQFGLWTPHY LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA //