ID   TOM6_HUMAN              Reviewed;          74 AA.
AC   Q96B49; B2DG15; Q9UH52;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   28-JUN-2011, entry version 55.
DE   RecName: Full=Mitochondrial import receptor subunit TOM6 homolog;
DE   AltName: Full=Overexpressed breast tumor protein;
DE   AltName: Full=Translocase of outer membrane 6 kDa subunit homolog;
GN   Name=TOMM6; Synonyms=OBTP, TOM6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=18331822; DOI=10.1016/j.bbrc.2008.02.150;
RA   Kato H., Mihara K.;
RT   "Identification of Tom5 and Tom6 in the preprotein translocase complex
RT   of human mitochondrial outer membrane.";
RL   Biochem. Biophys. Res. Commun. 369:958-963(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver cancer;
RA   Kok L.D., Au T.C., Fung K.P., Lee C.Y., Tsui S.K., Waye M.M.;
RT   "Identification of a novel human over-expressed breast tumor protein
RT   in hepatocellular carcinoma.";
RL   Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow, Prostate, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Hepatoma;
RX   PubMed=16097034; DOI=10.1002/pmic.200401217;
RA   Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K.,
RA   Demol H., Martens L., Goethals M., Vandekerckhove J.;
RT   "Global phosphoproteome analysis on human HepG2 hepatocytes using
RT   reversed-phase diagonal LC.";
RL   Proteomics 5:3589-3599(2005).
CC   -!- SUBUNIT: Forms part of the preprotein translocase complex of the
CC       outer mitochondrial membrane (TOM complex) which consists of at
CC       least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22,
CC       TOMM40 and TOMM70).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane.
CC   -!- SIMILARITY: Belongs to the Tom6 family.
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DR   EMBL; AB435319; BAG30996.1; -; mRNA.
DR   EMBL; AF216754; AAF25683.1; -; mRNA.
DR   EMBL; AL365205; CAM16154.1; -; Genomic_DNA.
DR   EMBL; BC015975; AAH15975.1; -; mRNA.
DR   EMBL; BC018624; AAH18624.1; -; mRNA.
DR   EMBL; BC022274; AAH22274.1; -; mRNA.
DR   IPI; IPI00386294; -.
DR   RefSeq; NP_001127965.1; NM_001134493.1.
DR   UniGene; Hs.525899; -.
DR   ProteinModelPortal; Q96B49; -.
DR   PhosphoSite; Q96B49; -.
DR   PRIDE; Q96B49; -.
DR   Ensembl; ENST00000398881; ENSP00000381856; ENSG00000214736.
DR   Ensembl; ENST00000398884; ENSP00000381859; ENSG00000214736.
DR   GeneID; 100188893; -.
DR   KEGG; hsa:100188893; -.
DR   CTD; 100188893; -.
DR   GeneCards; GC06P041473; -.
DR   H-InvDB; HIX0005871; -.
DR   HGNC; HGNC:34528; TOMM6.
DR   HPA; HPA004801; -.
DR   neXtProt; NX_Q96B49; -.
DR   PharmGKB; PA164726679; -.
DR   GeneTree; ENSGT00390000002376; -.
DR   HOGENOM; HBG282058; -.
DR   HOVERGEN; HBG054583; -.
DR   InParanoid; Q96B49; -.
DR   OMA; NVGDWLR; -.
DR   OrthoDB; EOG4FJ8BH; -.
DR   CleanEx; HS_TOMM6; -.
DR   Genevestigator; Q96B49; -.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Complete proteome; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Phosphoprotein; Protein transport;
KW   Transport.
FT   CHAIN         1     74       Mitochondrial import receptor subunit
FT                                TOM6 homolog.
FT                                /FTId=PRO_0000302856.
FT   MOD_RES      63     63       Phosphoserine.
FT   CONFLICT     16     16       E -> K (in Ref. 2; AAF25683).
SQ   SEQUENCE   74 AA;  8002 MW;  805462C0444865FD CRC64;
     MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG LFAAGVWLAR
     NLSDIDLMAP QPGV
//