ID Q968Y9_CAEEL PRELIMINARY; PRT; 1843 AA. AC Q968Y9; DT 01-DEC-2001 (TrEMBLrel. 19, Created) DT 01-DEC-2001 (TrEMBLrel. 19, Last sequence update) DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update) DE Abnormal dauer formation protein 2. GN Name=daf-2; ORFNames=Y55D5A.5; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). CC -!- CATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + a protein CC tyrosine phosphate. CC -!- SUBCELLULAR LOCATION: Type I membrane protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC084196; AAK29947.2; -; Genomic_DNA. DR HSSP; P08069; 1JQH. DR Ensembl; Y55D5A.5; Caenorhabditis elegans. DR WormBase; WBGene00000898; daf-2. DR WormPep; Y55D5A.5; CE27499. DR GO; GO:0016020; C:membrane; IEA. DR GO; GO:0005524; F:ATP binding; IEA. DR GO; GO:0005006; F:epidermal growth factor receptor activity; IEA. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA. DR InterPro; IPR000194; ATPase_a/bcentre. DR InterPro; IPR000494; EGF_rcpt_L. DR InterPro; IPR003961; FN_III. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR002290; Ser_thr_pkinase. DR InterPro; IPR001245; Tyr_pkinase. DR InterPro; IPR008266; Tyr_pkinase_AS. DR Pfam; PF00041; fn3; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR Pfam; PF01030; Recep_L_domain; 2. DR PRINTS; PR00109; TYRKINASE. DR ProDom; PD000001; Prot_kinase; 1. DR SMART; SM00060; FN3; 2. DR SMART; SM00219; TyrKc; 1. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; UNKNOWN_1. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; UNKNOWN_1. KW ATP-binding; Complete proteome; Developmental protein; Kinase; KW Nucleotide-binding; Receptor; Repeat; Transferase; Transmembrane; KW Tyrosine-protein kinase. SQ SEQUENCE 1843 AA; 206736 MW; B64692E2EC8A96AD CRC64; MNIVRCRRRH KILENLEEEN LGPSCSSTTS TTAATEALGT TTEDMRLKQQ RSSSRATEHD IVDGNHHDDE HITMRRLRLV KNSRTRRRTT PDSSMDCYEE NPPSQKTSIN YSWISKKSSM TSLMLLLLFA FVQPCASIVE KRCGPIDIRN RPWDIKPQWS KLGDPNEKDL AGQRMVNCTV VEGSLTISFV LKHKTKAQEE MHRSLQPRYS QDEFITFPHL REITGTLLVF ETEGLVDLRK IFPNLRVIGG RSLIQHYALI IYRNPDLEIG LDKLSVIRNG GVRIIDNRKL CYTKTIDWKH LITSSINDVV VDNAAEYAVT ETGLMCPRGA CEEDKGESKC HYLEEKNQEQ GVERVQSCWS NTTCQKSCAY DRLLPTKEIG PGCDANGDRC HDQCVGGCER VNDATACHAC KNVYHKGKCI EKCDAHLYLL LQRRCVTREQ CLQLNPVLSN KTVPIKATAG LCSDKCPDGY QINPDDHREC RKCVGKCEIV CEINHVIDTF PKAQAIRLCN IIDGNLTIEI RGKQDSGMAS ELKDIFANIH TITGYLLVRQ SSPFISLNMF RNLRRIEAKS LFRNLYAITV FENPNLKKLF DSTTDLTLDR GTVSIANNKM LCFKYIKQLM SKLNIPLDPI DQSEGTNGEK AICEDMAINV SITAVNADSV FFSWPSFNIT DIDQRKFLGY ELFFKEVPRI DENMTIEEDR SACVDSWQSV FKQYYETSNG EPTPDIFMDI GPRERIRPNT LYAYYVATQM VLHAGAKNGV SKIGFVRTSY YTPDPPTLAL AQVDSDAIHI TWEAPLQPNG DLTHYTIMWR ENEVSPYEEA EKFCTDASTP ANRQHTKDPK ETIVADKPVD IPSSRTVAPT LLTMMGHEDQ QKTCAATPGC CSCSAIEESS EQNKKKRPDP MSAIESSAFE NKLLDEVLMP RDTMRVRRSI EDANRVSEEL EKAENLGKAP KTLGGKKPLI HISKKKPSSS STTSTPAPTI ASMYALTRKP TTVPGTRIRL YEIYEPLPGS WAINVSALAL DNSYVIRNLK HYTLYAISLS ACQNMTVPGA SCSISHRAGA LKRTKHITDI DKVLNETIEW RFMNNSQQVN VTWDPPTEVN GGIFGYVVKL KSKVDGSIVM TRCVGAKRGY STRNQGVLFQ NLADGRYFVS VTATSVHGAG PEAESSDPIV VMTPGFFTVE IILGMLLVFL ILMSIAGCII YYYIQVRYGK KVKALSDFMQ LNPEYCVDNK YNADDWELRQ DDVVLGQQCG EGSFGKVYLG TGNNVVSLMG DRFGPCAIKI NVDDPASTEN LNYLMEANIM KNFKTNFIVK LYGVISTVQP AMVVMEMMDL GNLRDYLRSK REDEVFNETD CNFFDIIPRD KFHEWAAQIC DGMAYLESLK FCHRDLAARN CMINRDETVK IGDFGMARDL FYHDYYKPSG KRMMPVRWMS PESLKDGKFD SKSDVWSFGV VLYEMVTLGA QPYIGLSNDE VLNYIGMARK VIKKPECCEN YWYKVMKMCW RYSPRDRPTF LQLVHLLAAE ASPEFRDLSF VLTDNQMILD DSEALDLDDI DDTDMNDQVV EVAPDVENVE VQSDSERRNT DSIPLKQFKT IPPINATTSH STISIDETPM KAKQREGSLD EEYALMNHSG GPSDAEVRTY AGDGDYVERD VRENDVPTRR NTGASTSSYT GGGPYCLTNR GGSNERGAGF GEAVRLTDGV GSGHLNDDDY VEKEISSMDT RRSTGASSSS YGVPQTNWSG NRGATYYTSK AQQAATAAAA AAAALQQQQN GGRGDRLTQL PGTGHLQSTR GGQDGDYIET EPKNYRNNGS PSRNGNSRDI FNGRSAFGEN EHLIEDNEHH PLV //