ID Q960E2_DROME Unreviewed; 712 AA. AC Q960E2; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 02-JUN-2021, entry version 98. DE SubName: Full=SD05186p {ECO:0000313|EMBL:AAK93528.1}; GN Name=Karybeta3 {ECO:0000313|EMBL:AAK93528.1, GN ECO:0000313|FlyBase:FBgn0087013}; GN Synonyms=Kary-beta-3 {ECO:0000313|FlyBase:FBgn0087013}; GN ORFNames=CG1059 {ECO:0000313|FlyBase:FBgn0087013}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAK93528.1}; RN [1] {ECO:0000313|EMBL:AAK93528.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY052104; AAK93528.1; -; mRNA. DR PeptideAtlas; Q960E2; -. DR EnsemblMetazoa; FBtr0078860; FBpp0078500; FBgn0087013. DR FlyBase; FBgn0087013; Karybeta3. DR HOGENOM; CLU_003794_0_0_1; -. DR ChiTaRS; Karybeta3; fly. DR Bgee; FBgn0087013; Expressed in female gonad and 38 other tissues. DR ExpressionAtlas; Q960E2; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central. DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central. DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000357; HEAT. DR InterPro; IPR021133; HEAT_type_2. DR InterPro; IPR040122; Importin_beta. DR InterPro; IPR040928; Importin_rep_5. DR InterPro; IPR041389; Importin_rep_6. DR PANTHER; PTHR10527; PTHR10527; 1. DR Pfam; PF02985; HEAT; 1. DR Pfam; PF18816; Importin_rep_5; 1. DR Pfam; PF18829; Importin_rep_6; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS50077; HEAT_REPEAT; 1. PE 2: Evidence at transcript level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Protein transport {ECO:0000256|ARBA:ARBA00022927}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transport {ECO:0000256|ARBA:ARBA00022448}. FT REPEAT 514..551 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" SQ SEQUENCE 712 AA; 79119 MW; D8D9B868BC2E341E CRC64; MEAILDEVMS GVLNFLSDPH PRVRYAACNA IGQMSTDFAQ TFEKKFHSQV IPGLLSLLDD VENPRVQAHA GAALVNFSED CPKNILTRYL DGIMAKLETI LNSKFKELVE KGNKLVLEQV VTTIASVADT CESEFVAYYD RLMPCLKFII QNANSDDLRM LRGKTIECVS LIGLAVGREK FIGDAGEVMD MLLVNHTEGG ELADDDPQTS YLITAWARMC KILGKQFEQY LPLVMGPVMR TATMKPEVAM LDNDEVEDID GDVDWSFINL GEQQNFAIRT AGMDDKASAC EMLVCYAREL KEGFAEYAED VVRQMLPMLK FYFHDGVRTA AAESLPYLLD CAKIKGPQYL EGMWMFICPE LLKVIVTEPE PDVQSELLNS LAKCIETLGP NCLNEDAMKQ VLEIINKYVL EHFERADKRL AARNEEDYDD GVEEELAEQD DTDVYILSKI VDITHALFQT NKAQFLPAFE QVAPHFVKLL EPSRPVADRQ WGLCVFDDLI EFCGPACAPY QQIFTPALVQ YVCDKAPEVR QAAAYGCGVL GQFAGEQFAH TCAQIIPLLV QVINDPKARE IENISPTENA ISAFAKILKY NNSALSNVDE LIGVWFSWLP VSEDSEEAAH IYGYLCDLIE GNHPVILGAN NGNLPRIVSI IAESFCTKVV EAQSATGTRM LTIVKQVESN PEVMAACAST LSPEQQQALQ DAYRELANVA PA //