ID Q960E2_DROME Unreviewed; 712 AA. AC Q960E2; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 24-JAN-2024, entry version 104. DE SubName: Full=SD05186p {ECO:0000313|EMBL:AAK93528.1}; GN Name=Karybeta3 {ECO:0000313|EMBL:AAK93528.1, GN ECO:0000313|FlyBase:FBgn0087013}; GN Synonyms=Kary-beta-3 {ECO:0000313|FlyBase:FBgn0087013}; GN ORFNames=CG1059 {ECO:0000313|FlyBase:FBgn0087013}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAK93528.1}; RN [1] {ECO:0000313|EMBL:AAK93528.1} RP NUCLEOTIDE SEQUENCE. RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY052104; AAK93528.1; -; mRNA. DR AlphaFoldDB; Q960E2; -. DR PeptideAtlas; Q960E2; -. DR EnsemblMetazoa; FBtr0078860; FBpp0078500; FBgn0087013. DR AGR; FB:FBgn0087013; -. DR FlyBase; FBgn0087013; Karybeta3. DR VEuPathDB; VectorBase:FBgn0087013; -. DR HOGENOM; CLU_003794_0_0_1; -. DR ChiTaRS; Karybeta3; fly. DR Bgee; FBgn0087013; Expressed in wing disc and 25 other cell types or tissues. DR ExpressionAtlas; Q960E2; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IDA:FlyBase. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central. DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central. DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central. DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR032682; Cnd1_C. DR InterPro; IPR000357; HEAT. DR InterPro; IPR021133; HEAT_type_2. DR InterPro; IPR040122; Importin_beta. DR InterPro; IPR040928; Importin_rep_5. DR InterPro; IPR041389; Importin_rep_6. DR PANTHER; PTHR10527; IMPORTIN BETA; 1. DR PANTHER; PTHR10527:SF5; KARYOPHERIN (IMPORTIN) BETA 3; 1. DR Pfam; PF12717; Cnd1; 1. DR Pfam; PF02985; HEAT; 1. DR Pfam; PF18816; Importin_rep_5; 1. DR Pfam; PF18829; Importin_rep_6; 1. DR SUPFAM; SSF48371; ARM repeat; 1. DR PROSITE; PS50077; HEAT_REPEAT; 1. PE 2: Evidence at transcript level; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 2..126 FT /note="Condensin complex subunit 1 C-terminal" FT /evidence="ECO:0000259|Pfam:PF12717" FT REPEAT 514..551 FT /note="HEAT" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103" SQ SEQUENCE 712 AA; 79119 MW; D8D9B868BC2E341E CRC64; MEAILDEVMS GVLNFLSDPH PRVRYAACNA IGQMSTDFAQ TFEKKFHSQV IPGLLSLLDD VENPRVQAHA GAALVNFSED CPKNILTRYL DGIMAKLETI LNSKFKELVE KGNKLVLEQV VTTIASVADT CESEFVAYYD RLMPCLKFII QNANSDDLRM LRGKTIECVS LIGLAVGREK FIGDAGEVMD MLLVNHTEGG ELADDDPQTS YLITAWARMC KILGKQFEQY LPLVMGPVMR TATMKPEVAM LDNDEVEDID GDVDWSFINL GEQQNFAIRT AGMDDKASAC EMLVCYAREL KEGFAEYAED VVRQMLPMLK FYFHDGVRTA AAESLPYLLD CAKIKGPQYL EGMWMFICPE LLKVIVTEPE PDVQSELLNS LAKCIETLGP NCLNEDAMKQ VLEIINKYVL EHFERADKRL AARNEEDYDD GVEEELAEQD DTDVYILSKI VDITHALFQT NKAQFLPAFE QVAPHFVKLL EPSRPVADRQ WGLCVFDDLI EFCGPACAPY QQIFTPALVQ YVCDKAPEVR QAAAYGCGVL GQFAGEQFAH TCAQIIPLLV QVINDPKARE IENISPTENA ISAFAKILKY NNSALSNVDE LIGVWFSWLP VSEDSEEAAH IYGYLCDLIE GNHPVILGAN NGNLPRIVSI IAESFCTKVV EAQSATGTRM LTIVKQVESN PEVMAACAST LSPEQQQALQ DAYRELANVA PA //