ID Q95YM9_HALRO PRELIMINARY; PRT; 763 AA. AC Q95YM9; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 04-APR-2006, entry version 16. DE FGFR. GN Name=HrfgfR; OS Halocynthia roretzi (Sea squirt). OC Eukaryota; Metazoa; Chordata; Urochordata; Ascidiacea; OC Stolidobranchia; Pyuridae; Halocynthia. OX NCBI_TaxID=7729; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21417207; PubMed=11526077; RA Shimauchi Y., Murakami S.D., Satoh N.; RT "FGF signals are involved in the differentiation of notochord cells RT and mesenchyme cells of the ascidian Halocynthia roretzi."; RL Development 128:2711-2721(2001). CC -!- CATALYTIC ACTIVITY: ATP + a protein tyrosine = ADP + a protein CC tyrosine phosphate. CC -!- SUBCELLULAR LOCATION: Membrane; single-pass type I membrane CC protein (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB046873; BAB59007.1; -; mRNA. DR HSSP; P11362; 1EVT. DR GO; GO:0005524; F:ATP binding; IEA. DR GO; GO:0004713; F:protein-tyrosine kinase activity; IEA. DR GO; GO:0006468; P:protein amino acid phosphorylation; IEA. DR InterPro; IPR013098; I-set. DR InterPro; IPR003599; Ig. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003598; Ig_c2. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR000719; Prot_kinase. DR InterPro; IPR002290; Ser_thr_pkinase. DR InterPro; IPR001245; Tyr_pkinase. DR InterPro; IPR008266; Tyr_pkinase_AS. DR Pfam; PF07679; I-set; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF07714; Pkinase_Tyr; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00409; IG; 2. DR SMART; SM00408; IGc2; 2. DR SMART; SM00219; TyrKc; 1. DR PROSITE; PS50835; IG_LIKE; 2. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. KW ATP-binding; Immunoglobulin domain; Kinase; Membrane; KW Nucleotide-binding; Receptor; Repeat; Transferase; Transmembrane; KW Tyrosine-protein kinase. SQ SEQUENCE 763 AA; 86741 MW; A34C1871DB796950 CRC64; MKEFEVKVAS TAFVLVLFSL TINQILASET STKFRSPVPA PTVPDWNHLP NEGNEENVVS APKQDGASGG QKPYWTKREK MMKRLHAEPA GNTVRFRCAV DGNPKPQVLW YKNDLIVQKN DRVGGYKYRN QVLILESVVL SDKGNYMCVA RNEYGSINHT YQLDVQERSA SKPILAEGLP QNKSAYIGDD VTFKCKVYSD AHPHIQWLKS INNHNNAAPN YTVLKAAGVN TTDLDMEVLI LKNVSFEEAG EYTCLAGNSI GISHQSAWLS VLPVPPPTTD TITKGIPNET NIIIYVMCGV LVILFGLAVV LVLYYHCYNG KDPPMLVRIE NPDNIPPMTK IEHPTMLFGN TQAWQRMCMP MQEPFEFNIQ LDLQWELQRE DITLVERLDE GFFGQVFKAD LVTCNNTRKE KMVCAVKMLK GNRNEKDVLD LLTEMDQMKR VGKHKNIINL LGVCTQNGPL WLVIEYAAQG NLRDYLRRNR PQNTLCNLVL PSEGRNPDDE LPVPHGDTLT QKDIVSFAFQ VARGLEFLAQ KKCIHRDLAA RNVLVTEELV MKIADFGLAR DIRSCDYYRK HTRGHLPYKW MALEAMSDNI FTHATDVWSF GVLLWEIFSL AGSPYPGIKT HELVKFLRSG ERLDKPQYAS QEMYRLMRDC WEEDPSKRPN FRTLVEDLDR MLAESSTEVY IDFAAGCEAE YSESSEDESE SQNSDEEDDD SVFERMRQID SLSNGNIPFN EEDSSNSDPY VAPLLQNEEN VLQNEHARLR SEA //