ID Q95WK4_ANOQU Unreviewed; 153 AA. AC Q95WK4; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 07-OCT-2020, entry version 69. DE RecName: Full=Glucose-6-phosphate 1-dehydrogenase {ECO:0000256|ARBA:ARBA00020444}; DE Flags: Fragment; GN Name=G6pd {ECO:0000313|EMBL:AAL18428.1}; OS Anopheles quadrimaculatus (Common malaria mosquito). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Nematocera; Culicoidea; Culicidae; OC Anophelinae; Anopheles. OX NCBI_TaxID=7166 {ECO:0000313|EMBL:AAL18428.1}; RN [1] {ECO:0000313|EMBL:AAL18428.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12116652; DOI=10.1080/106351501750435095; RA Krzywinski J., Wilkerson R.C., Besansky N.J.; RT "Toward understanding Anophelinae (Diptera, Culicidae) phylogeny: insights RT from nuclear single-copy genes and the weight of evidence."; RL Syst. Biol. 50:540-556(2001). CC -!- FUNCTION: Cytosolic glucose-6-phosphate dehydrogenase that catalyzes CC the first and rate-limiting step of the oxidative branch within the CC pentose phosphate pathway/shunt, an alternative route to glycolysis for CC the dissimilation of carbohydrates and a major source of reducing power CC and metabolic intermediates for fatty acid and nucleic acid CC biosynthetic processes. {ECO:0000256|ARBA:ARBA00002914}. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5- CC lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349, CC ChEBI:CHEBI:61548; EC=1.1.1.49; CC Evidence={ECO:0000256|ARBA:ARBA00001220}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15842; CC Evidence={ECO:0000256|ARBA:ARBA00001220}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF317809; AAL18428.1; -; Genomic_DNA. DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:UniProtKB-EC. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR001282; G6P_DH. DR InterPro; IPR022674; G6P_DH_NAD-bd. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR23429; PTHR23429; 1. DR Pfam; PF00479; G6PD_N; 1. DR PRINTS; PR00079; G6PDHDRGNASE. DR SUPFAM; SSF51735; SSF51735; 1. PE 4: Predicted; KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526}. FT DOMAIN 1..152 FT /note="G6PD_N" FT /evidence="ECO:0000259|Pfam:PF00479" FT COILED 26..46 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAL18428.1" FT NON_TER 153 FT /evidence="ECO:0000313|EMBL:AAL18428.1" SQ SEQUENCE 153 AA; 17901 MW; 48F4D50B38AC19DD CRC64; LWWLFRDNLV PSDTKFVGYA RSKLSVAELK EKCRQYMKVK DAELEKFDEF WSVNFYVAGS YDSRRDFELL NQEIAKFEVG RAANRLFYLA LPPSVFESVT VHIRNTCMGE KGWNRIIVEK PFGRDASSSN ALSAHLSKLF SEDQLYRIDH YLV //