ID S45A3_MACFA Reviewed; 553 AA. AC Q95KI5; Q95KC5; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 14-DEC-2022, entry version 61. DE RecName: Full=Solute carrier family 45 member 3; DE AltName: Full=Prostate cancer-associated protein 6; DE AltName: Full=Prostein; GN Name=SLC45A3; Synonyms=PCANAP6, PRST; ORFNames=QmoA-10594, QtrA-11310; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Medulla oblongata, and Temporal cortex; RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., RA Suzuki Y., Sugano S., Hashimoto K.; RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries."; RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Proton-associated sucrose transporter. May be able to CC transport also glucose and fructose. {ECO:0000250|UniProtKB:Q8K0H7}. CC -!- CATALYTIC ACTIVITY: CC Reaction=H(+)(out) + sucrose(out) = H(+)(in) + sucrose(in); CC Xref=Rhea:RHEA:72187, ChEBI:CHEBI:15378, ChEBI:CHEBI:17992; CC Evidence={ECO:0000250|UniProtKB:Q8K0H7}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation CC symporter transporter (TC 2.A.2) family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB60745.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB060851; BAB46871.1; -; mRNA. DR EMBL; AB062977; BAB60745.1; ALT_INIT; mRNA. DR RefSeq; XP_005540658.1; XM_005540601.2. DR RefSeq; XP_005540661.1; XM_005540604.2. DR AlphaFoldDB; Q95KI5; -. DR STRING; 9541.XP_005540658.1; -. DR GeneID; 102115659; -. DR eggNOG; KOG0637; Eukaryota. DR Proteomes; UP000233100; Unplaced. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008506; F:sucrose:proton symporter activity; ISS:UniProtKB. DR GO; GO:0015770; P:sucrose transport; ISS:UniProtKB. DR Gene3D; 1.20.1250.20; -; 2. DR InterPro; IPR011701; MFS. DR InterPro; IPR036259; MFS_trans_sf. DR Pfam; PF07690; MFS_1; 1. DR SUPFAM; SSF103473; MFS general substrate transporter; 1. PE 2: Evidence at transcript level; KW Membrane; Reference proteome; Symport; Transmembrane; Transmembrane helix; KW Transport. FT CHAIN 1..553 FT /note="Solute carrier family 45 member 3" FT /id="PRO_0000122520" FT TRANSMEM 19..39 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TRANSMEM 52..72 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TRANSMEM 88..108 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TRANSMEM 120..140 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TRANSMEM 161..181 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TRANSMEM 198..218 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TRANSMEM 275..295 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TRANSMEM 323..343 FT /note="Helical; Name=8" FT /evidence="ECO:0000255" FT TRANSMEM 353..373 FT /note="Helical; Name=9" FT /evidence="ECO:0000255" FT TRANSMEM 382..402 FT /note="Helical; Name=10" FT /evidence="ECO:0000255" FT TRANSMEM 522..542 FT /note="Helical; Name=11" FT /evidence="ECO:0000255" FT CONFLICT 165 FT /note="A -> T (in Ref. 1; BAB60745)" FT /evidence="ECO:0000305" FT CONFLICT 342 FT /note="M -> V (in Ref. 1; BAB60745)" FT /evidence="ECO:0000305" SQ SEQUENCE 553 AA; 59393 MW; 0718F3A91FB3BF1E CRC64; MVQRLWVSRL LRHRKAQLLL INLLTFGLEV CLAAGITYVP PLLLEVGVEE KFMTMVLGIG PVLGLVSVPL LGSASDHWRG RYGRRRPFIW ALSLGILLSL FLIPRAGWLA GLLCPDPRPL ELALLILGVG LLDFCGQVCF TPLEALLSDL FRDPDHCRQA YSVYAFMISL GGCLGYLLPA IDWDTSALAP YLGTQEECLF GLLTLIFLTC VAATLLVAEE AALGPAEPAE GLSAPSLPSH CCPCWARLAF RNLGALLPRL HQLCCRMPRT LRRLFVAELC SWMALMTFTL FYTDFVGEGL YQGVPRAELG TEARRHYDEG VRMGSLGLFL QCAISLVFSL VMDRLVQRFG TRAVYLASVA AFPVAAGATC LSHSVAVVTA SAALTGFTFS ALQILPYTLA SLYHRERQVF LPKYRGDAGG TSSEDSLMTS FLPGPKPGAP FPNGHVGAGG SGLLPPPPAL CGASACDVSV RVVVGEPTEA RVVPGRGICL DLAILDSAFL LSQVAPSLFM GSIVQLSQSV TAYMVSAAGL GLVAIYFATQ VVFDKSDLAK YSV //