ID OPTN_MACFA Reviewed; 571 AA. AC Q95KA2; Q9BGR3; DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 29-MAR-2005, sequence version 2. DT 05-OCT-2010, entry version 36. DE RecName: Full=Optineurin; GN Name=OPTN; ORFNames=QflA-13191, QmoA-11721; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Frontal cortex, and Medulla oblongata; RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., RA Suzuki Y., Sugano S., Hashimoto K.; RT "Isolation of full-length cDNA clones from macaque brain cDNA RT libraries."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays an important role in the maintenance of the Golgi CC complex, in membrane trafficking, in exocytosis, through its CC interaction with myosin VI and Rab8. Links myosin VI to the Golgi CC complex and plays an important role in Golgi ribbon formation. CC Plays a neuroprotective role in the eye and optic nerve. Probably CC part of the TNF-alpha signaling pathway that can shift the CC equilibrium toward induction of cell death. May act by regulating CC membrane trafficking and cellular morphogenesis via a complex that CC contains Rab8 and hungtingtin (HD) (By similarity). CC -!- SUBUNIT: Interacts with HD. Interacts with Rab8 (RAB8A and/or CC RAB8B). Interacts with transcription factor IIIA (GTF3A). CC Interacts with TRAF3, TBK1 and MYO6. Binds to ubiquitin (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By CC similarity). Golgi apparatus (By similarity). Golgi apparatus, CC trans-Golgi network (By similarity). Note=Found in the perinuclear CC region and associates with the Golgi apparatus. Colocalizes with CC MYO6 and RAB8 at the Golgi complex and in vesicular structures CC close to the plasma membrane (By similarity). CC -!- DOMAIN: Ubiquitin-binding motif (UBAN) is essential for its CC inhibitory function, subcellular localization and interaction with CC TBK1 (By similarity). CC -!- PTM: Phosphorylated (By similarity). CC -!- SEQUENCE CAUTION: CC Sequence=BAB60774.1; Type=Frameshift; Positions=23; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB056409; BAB33067.1; -; mRNA. DR EMBL; AB063036; BAB60774.1; ALT_FRAME; mRNA. DR ProteinModelPortal; Q95KA2; -. DR SMR; Q95KA2; 43-101, 545-571. DR HOVERGEN; HBG106481; -. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB. DR GO; GO:0090161; P:Golgi ribbon formation; ISS:UniProtKB. DR InterPro; IPR021063; NEMO. DR Pfam; PF11577; NEMO; 1. PE 2: Evidence at transcript level; KW Coiled coil; Cytoplasm; Golgi apparatus; Phosphoprotein. FT CHAIN 1 571 Optineurin. FT /FTId=PRO_0000058067. FT REGION 406 514 Interaction with MYO6 (By similarity). FT COILED 38 170 Potential. FT COILED 233 502 Potential. FT MOTIF 468 473 UBAN. FT MOD_RES 170 170 Phosphoserine (By similarity). FT MOD_RES 171 171 Phosphoserine (By similarity). FT MOD_RES 173 173 Phosphoserine (By similarity). FT MOD_RES 174 174 Phosphoserine (By similarity). FT MOD_RES 177 177 Phosphoserine (By similarity). FT MOD_RES 336 336 Phosphoserine (By similarity). SQ SEQUENCE 571 AA; 65046 MW; D5D6822940397E1D CRC64; MSHQPLSCLT EKGDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTGDSR LPRAEAEQEK DQLRTQVTRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSIGTS RSAEGAKNYL EHEELTVSQL LLCLREGNQK VERLEIALKE AKERVSDFEK KASNRSEIET QTEGSTEKEN EEEKGPETVG SEVEALNLQV TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY TNKKLELQVE SMLSEIKMEQ AKTEDEKSKL AMLQLTHNKL LQEHNHALKT IEELTRKESE KVDRAVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE DLETMTVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDAF EDGGRQSLME MQSRHGARTS DPDQQAYLVQ RGTEDRDWQQ QRNIPIHSCP KCGEVLPDID TLQIHVMDCI I //