ID OPTN_MACFA Reviewed; 571 AA. AC Q95KA2; Q9BGR3; DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 29-MAR-2005, sequence version 2. DT 20-FEB-2007, entry version 21. DE Optineurin. GN Name=OPTN; ORFNames=QflA-13191, QmoA-11721; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Frontal cortex, and Medulla oblongata; RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., RA Suzuki Y., Sugano S., Hashimoto K.; RT "Isolation of full-length cDNA clones from macaque brain cDNA RT libraries."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays a neuroprotective role in the eye and optic nerve. CC Probably part of the TNF-alpha signaling pathway that can shift CC the equilibrium toward induction of cell death. May act by CC regulating membrane trafficking and cellular morphogenesis via a CC complex that contains Rab8 and hungtingtin (HD) (By similarity). CC -!- SUBUNIT: Interacts with HD. Interacts with Rab8 (RAB8A and/or CC RAB8B). Interacts with transcription factor IIIA (GTF3A) (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm; perinuclear region (By CC similarity). Golgi apparatus (By similarity). Note=Found in the CC perinuclear region and associates with the Golgi apparatus. CC -!- PTM: Phosphorylated (By similarity). CC -!- CAUTION: Ref.1 (BAB60774) sequence differs from that shown due to CC a frameshift in position 23. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB056409; BAB33067.1; -; mRNA. DR EMBL; AB063036; BAB60774.1; ALT_FRAME; mRNA. KW Coiled coil; Golgi apparatus; Phosphorylation. FT CHAIN 1 571 Optineurin. FT /FTId=PRO_0000058067. FT COILED 38 170 Potential. FT COILED 233 502 Potential. FT MOD_RES 170 170 Phosphoserine (By similarity). FT MOD_RES 171 171 Phosphoserine (By similarity). FT MOD_RES 173 173 Phosphoserine (By similarity). FT MOD_RES 174 174 Phosphoserine (By similarity). SQ SEQUENCE 571 AA; 65046 MW; D5D6822940397E1D CRC64; MSHQPLSCLT EKGDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTGDSR LPRAEAEQEK DQLRTQVTRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSIGTS RSAEGAKNYL EHEELTVSQL LLCLREGNQK VERLEIALKE AKERVSDFEK KASNRSEIET QTEGSTEKEN EEEKGPETVG SEVEALNLQV TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY TNKKLELQVE SMLSEIKMEQ AKTEDEKSKL AMLQLTHNKL LQEHNHALKT IEELTRKESE KVDRAVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE DLETMTVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDAF EDGGRQSLME MQSRHGARTS DPDQQAYLVQ RGTEDRDWQQ QRNIPIHSCP KCGEVLPDID TLQIHVMDCI I //