ID OPTN_MACFA STANDARD; PRT; 571 AA. AC Q95KA2; Q9BGR3; DT 10-MAY-2005 (Rel. 47, Created) DT 10-MAY-2005 (Rel. 47, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Optineurin. GN Name=OPTN; ORFNames=QflA-13191, QmoA-11721; OS Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Frontal cortex, and Medulla oblongata; RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K., RA Suzuki Y., Sugano S., Hashimoto K.; RT "Isolation of full-length cDNA clones from macaque brain cDNA RT libraries."; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Plays a neuroprotective role in the eye and optic nerve. CC Probably part of the TNF-alpha signaling pathway that can shift CC the equilibrium toward induction of cell death. May act by CC regulating membrane trafficking and cellular morphogenesis via a CC complex that contains Rab8 and hungtingtin (HD) (By similarity). CC -!- SUBUNIT: Interacts with HD. Interacts with Rab8 (RAB8A and/or CC RAB8B). Interacts with transcription factor IIIA (GTF3A) (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic. Found in the perinuclear region CC and associates with the Golgi apparatus (By similarity). CC -!- PTM: Phosphorylated (By similarity). CC -!- CAUTION: Ref.1 (BAB60774) sequence differs from that shown due to CC a frameshift in position 23. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB056409; BAB33067.1; -; mRNA. DR EMBL; AB063036; BAB60774.1; ALT_FRAME; mRNA. KW Coiled coil; Golgi stack; Phosphorylation. FT COILED 38 170 Potential. FT COILED 233 502 Potential. SQ SEQUENCE 571 AA; 65046 MW; D5D6822940397E1D CRC64; MSHQPLSCLT EKGDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL NNQAMKGRFE ELSAWTEKQK EERQFFETQS KEAKERLMAL SHENEKLKEE LGKLKGKSER SSEDPTGDSR LPRAEAEQEK DQLRTQVTRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE IRMAEGEAEG SVKEIKHSPG PTRTVSIGTS RSAEGAKNYL EHEELTVSQL LLCLREGNQK VERLEIALKE AKERVSDFEK KASNRSEIET QTEGSTEKEN EEEKGPETVG SEVEALNLQV TSLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY TNKKLELQVE SMLSEIKMEQ AKTEDEKSKL AMLQLTHNKL LQEHNHALKT IEELTRKESE KVDRAVLKEL SEKLELAEKA LASKQLQMDE MKQTIAKQEE DLETMTVLRA QMEVYCSDFH AERAAREKIH EEKEQLALQL AVLLKENDAF EDGGRQSLME MQSRHGARTS DPDQQAYLVQ RGTEDRDWQQ QRNIPIHSCP KCGEVLPDID TLQIHVMDCI I //