ID   Q95HB9_HUMAN            Unreviewed;       260 AA.
AC   Q95HB9;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-SEP-2017, entry version 129.
DE   SubName: Full=HLA-DPA1 protein {ECO:0000313|EMBL:AAH09956.1};
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AHW47932.1};
GN   Name=HLA-DPA1 {ECO:0000313|EMBL:AHW47932.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH09956.1};
RN   [1] {ECO:0000213|PDB:1M6O, ECO:0000213|PDB:1N2R}
RP   X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 77-85.
RX   PubMed=12939341; DOI=10.1084/jem.20030066;
RA   Macdonald W.A., Purcell A.W., Mifsud N.A., Ely L.K., Williams D.S.,
RA   Chang L., Gorman J.J., Clements C.S., Kjer-Nielsen L., Koelle D.M.,
RA   Burrows S.R., Tait B.D., Holdsworth R., Brooks A.G., Lovrecz G.O.,
RA   Lu L., Rossjohn J., McCluskey J.;
RT   "A naturally selected dimorphism within the HLA-B44 supertype alters
RT   class I structure, peptide repertoire, and T cell recognition.";
RL   J. Exp. Med. 198:679-691(2003).
RN   [2] {ECO:0000313|EMBL:AAH09956.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Primary B-Cells {ECO:0000313|EMBL:AAH09956.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000213|PDB:3L3D, ECO:0000213|PDB:3L3G, ECO:0000213|PDB:3L3I}
RP   X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 77-85.
RX   PubMed=20212169; DOI=10.1073/pnas.1000032107;
RA   Theodossis A., Guillonneau C., Welland A., Ely L.K., Clements C.S.,
RA   Williamson N.A., Webb A.I., Wilce J.A., Mulder R.J., Dunstone M.A.,
RA   Doherty P.C., McCluskey J., Purcell A.W., Turner S.J., Rossjohn J.;
RT   "Constraints within major histocompatibility complex class I
RT   restricted peptides: presentation and consequences for T-cell
RT   recognition.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:5534-5539(2010).
RN   [4] {ECO:0000313|EMBL:AHW47932.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Pyo C.-W., Wang K., Shen S., Song Y., Wang R., Vu Q., Hall R.J.,
RA   Eng K., Bowman B., Ranade S., Geraghty D.E.;
RT   "Haplotype-resolved resequencing of conserved extended haploytpes
RT   associated with disease using fosmid target capture and long-read SMRT
RT   sequencing technology.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ALX87261.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Chooi Y.-H.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AMK37689.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lazaro A.M., Hou L., Hurley C.K.;
RT   "Novel HLA DPA1 allele.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AML03227.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Jackson K.R., Lunt B.L., Fisher J.N.B., Gardner A.V., Bailey M.E.,
RA   Deus L.M., Earl A.S., Gibby P.D., Hartmann K.A., Liu J.E., Manci A.M.,
RA   Nielsen D.A., Solomon M.B., Breakwell D.P., Burnett S.H., Grose J.H.;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|RuleBase:RU004238, ECO:0000256|SAAS:SAAS00552561}.
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DR   EMBL; BC009956; AAH09956.1; -; mRNA.
DR   EMBL; KJ657694; AHW47932.1; -; Genomic_DNA.
DR   EMBL; KP774796; ALX87261.1; -; Genomic_DNA.
DR   EMBL; KP774797; ALX87262.1; -; Genomic_DNA.
DR   EMBL; KP774799; ALX87264.1; -; Genomic_DNA.
DR   EMBL; KP774800; ALX87265.1; -; Genomic_DNA.
DR   EMBL; KT725627; AMK37689.1; -; Genomic_DNA.
DR   EMBL; KT725628; AMK37690.1; -; Genomic_DNA.
DR   EMBL; KT716042; AML03227.1; -; Genomic_DNA.
DR   EMBL; KT716046; AML03231.1; -; Genomic_DNA.
DR   UniGene; Hs.347270; -.
DR   PDB; 1M6O; X-ray; 1.60 A; C=77-85.
DR   PDB; 1N2R; X-ray; 1.70 A; C=77-85.
DR   PDB; 3L3D; X-ray; 1.80 A; C=77-85.
DR   PDB; 3L3G; X-ray; 2.10 A; C=77-85.
DR   PDB; 3L3I; X-ray; 1.70 A; C=77-85.
DR   PDB; 3L3J; X-ray; 2.40 A; C=77-85.
DR   PDB; 3L3K; X-ray; 2.60 A; C=77-85.
DR   PDBsum; 1M6O; -.
DR   PDBsum; 1N2R; -.
DR   PDBsum; 3L3D; -.
DR   PDBsum; 3L3G; -.
DR   PDBsum; 3L3I; -.
DR   PDBsum; 3L3J; -.
DR   PDBsum; 3L3K; -.
DR   eggNOG; ENOG410IZMF; Eukaryota.
DR   eggNOG; ENOG410YHX9; LUCA.
DR   HOVERGEN; HBG006862; -.
DR   ChiTaRS; HLA-DPA1; human.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:1M6O, ECO:0000213|PDB:1N2R,
KW   ECO:0000213|PDB:3L3D, ECO:0000213|PDB:3L3G};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00465899};
KW   Immunity {ECO:0000256|SAAS:SAAS00437908};
KW   Membrane {ECO:0000256|SAAS:SAAS00437963, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|SAAS:SAAS00437896};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00437939,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00437953,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    260       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010977198.
FT   TRANSMEM    227    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      118    198       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   260 AA;  29335 MW;  5DD08E383269E05A CRC64;
     MRPEDRMFHI RAVILRALSL AFLLSLRGAG AIKADHVSTY AAFVQTHRPT GEFMFEFDED
     EQFYVDLDKK ETVWHLEEFG RAFSFEAQGG LANIAILNNN LNTLIQRSNH TQAANDPPEV
     TVFPKEPVEL GQPNTLICHI DRFFPPVLNV TWLCNGEPVT EGVAESLFLP RTDYSFHKFH
     YLTFVPSAED VYDCRVEHWG LDQPLLKHWE AQEPIQMPET TETVLCALGL VLGLVGIIVG
     TVLIIKSLRS GHDPRAQGPL
//