ID NU1C_WHEAT Reviewed; 362 AA. AC Q95H43; DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot. DT 27-JUN-2006, sequence version 2. DT 07-APR-2021, entry version 77. DE RecName: Full=NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic {ECO:0000255|HAMAP-Rule:MF_01350}; DE EC=7.1.1.- {ECO:0000255|HAMAP-Rule:MF_01350}; DE AltName: Full=NAD(P)H dehydrogenase subunit 1 {ECO:0000255|HAMAP-Rule:MF_01350}; DE Short=NDH subunit 1 {ECO:0000255|HAMAP-Rule:MF_01350}; DE AltName: Full=NADH-plastoquinone oxidoreductase subunit 1 {ECO:0000255|HAMAP-Rule:MF_01350}; GN Name=ndhA {ECO:0000255|HAMAP-Rule:MF_01350}; OS Triticum aestivum (Wheat). OG Plastid; Chloroplast. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum. OX NCBI_TaxID=4565; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Chinese Spring; RA Ogihara Y., Isono K., Kojima T., Endo A., Hanaoka M., Shiina T., RA Terachi T., Utsugi S., Murata M., Mori N., Takumi S., Ikeo K., Gojobori T., RA Murai R., Murai K., Matsuoka Y., Ohnishi Y., Tajiri H., Tsunewaki K.; RT "Chinese spring wheat (Triticum aestivum L.) chloroplast genome: complete RT sequence and contig clones."; RL Plant Mol. Biol. Rep. 18:243-253(2000). CC -!- FUNCTION: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN CC and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain CC and possibly in a chloroplast respiratory chain. The immediate electron CC acceptor for the enzyme in this species is believed to be CC plastoquinone. Couples the redox reaction to proton translocation, and CC thus conserves the redox energy in a proton gradient. CC {ECO:0000255|HAMAP-Rule:MF_01350}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:42608, Rhea:RHEA-COMP:9561, CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:62192; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01350}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n CC H(+)(out) + NADP(+); Xref=Rhea:RHEA:42612, Rhea:RHEA-COMP:9561, CC Rhea:RHEA-COMP:9562, ChEBI:CHEBI:15378, ChEBI:CHEBI:17757, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:62192; CC Evidence={ECO:0000255|HAMAP-Rule:MF_01350}; CC -!- SUBUNIT: NDH is composed of at least 16 different subunits, 5 of which CC are encoded in the nucleus. {ECO:0000255|HAMAP-Rule:MF_01350}. CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane CC {ECO:0000255|HAMAP-Rule:MF_01350}; Multi-pass membrane protein CC {ECO:0000255|HAMAP-Rule:MF_01350}. CC -!- RNA EDITING: Modified_positions=158 {ECO:0000250}, 188 {ECO:0000250}, CC 357 {ECO:0000250}; CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000255|HAMAP-Rule:MF_01350}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB042240; BAB47090.1; -; Genomic_DNA. DR RefSeq; NP_114313.1; NC_002762.1. DR STRING; 4565.Traes_5AL_FFD2F60A3.1; -. DR GeneID; 803191; -. DR eggNOG; KOG4770; Eukaryota. DR OMA; XEVEDIN; -. DR Proteomes; UP000019116; Chloroplast. DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProtKB-UniRule. DR GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW. DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central. DR GO; GO:0019684; P:photosynthesis, light reaction; IEA:UniProtKB-UniRule. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR PANTHER; PTHR11432; PTHR11432; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. PE 3: Inferred from homology; KW Chloroplast; Membrane; NAD; NADP; Plastid; Plastoquinone; Quinone; KW Reference proteome; RNA editing; Thylakoid; Translocase; Transmembrane; KW Transmembrane helix. FT CHAIN 1..362 FT /note="NAD(P)H-quinone oxidoreductase subunit 1, FT chloroplastic" FT /id="PRO_0000117517" FT TRANSMEM 29..49 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 103..123 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 128..148 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 164..184 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 202..222 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 247..267 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 303..323 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" FT TRANSMEM 335..355 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01350" SQ SEQUENCE 362 AA; 40438 MW; ED5FBCBED86D900B CRC64; MIIDRVEVET INSFWKLELL KEVYGLISIL PILTLLLGIT IEVLVIVWLE REISASIQQR IGPEYAGPLG LLQAIADGTK LLFKEDILPS RGDISLFSIG PSIAVISVLL SFLVIPLGYH FVLADLSIGV FLWIAISSIA PIGLLMAGYS SNNKYSFLGG LRAAAQSISY EIPLTFCVLA ISLLSNSLST VDIVEAQSKY GFFGWNIWRQ PIGFLVFLIS SLAECERLPF DLPEAEEELV AGYQTEYSGI KYGLFYLVSY LNLLVSSLFV TVLYLGGWNL SIPYISFFDF FQMNKAVGIL EMTMGIFITL TKAYLFLFIS ITIRWTLPRM RMDQLLNLGW KFLLPISLGN LLLTTSFQLV SL //