ID ATP6_POLOR Reviewed; 227 AA. AC Q95913; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 07-OCT-2020, entry version 92. DE RecName: Full=ATP synthase subunit a; DE AltName: Full=F-ATPase protein 6; GN Name=mt-atp6; Synonyms=atp6, atpase6, mtatp6; OS Polypterus ornatipinnis (Ornate bichir). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Polypteriformes; Polypteridae; Polypterus. OX NCBI_TaxID=49895; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=8913758; RA Noack K., Zardoya R., Meyer A.; RT "The complete mitochondrial DNA sequence of the bichir (Polypterus RT ornatipinnis), a basal ray-finned fish: ancient establishment of the RT consensus vertebrate gene order."; RL Genetics 144:1165-1180(1996). CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or CC Complex V) produces ATP from ADP in the presence of a proton gradient CC across the membrane which is generated by electron transport complexes CC of the respiratory chain. F-type ATPases consist of two structural CC domains, F(1) - containing the extramembraneous catalytic core and F(0) CC - containing the membrane proton channel, linked together by a central CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the CC catalytic domain of F(1) is coupled via a rotary mechanism of the CC central stalk subunits to proton translocation. Key component of the CC proton channel; it may play a direct role in the translocation of CC protons across the membrane. CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core CC - and CF(0) - the membrane proton channel. CF(1) has five subunits: CC alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main CC subunits: a, b and c. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane CC protein. CC -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U62532; AAC60310.1; -; Genomic_DNA. DR PIR; T11459; T11459. DR RefSeq; NP_008321.1; NC_001778.1. DR PRIDE; Q95913; -. DR GeneID; 808032; -. DR CTD; 4508; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW. DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro. DR GO; GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. DR Gene3D; 1.20.120.220; -; 1. DR InterPro; IPR000568; ATP_synth_F0_asu. DR InterPro; IPR023011; ATP_synth_F0_asu_AS. DR InterPro; IPR035908; F0_ATP_A_sf. DR Pfam; PF00119; ATP-synt_A; 1. DR PRINTS; PR00123; ATPASEA. DR SUPFAM; SSF81336; SSF81336; 1. DR TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1. DR PROSITE; PS00449; ATPASE_A; 1. PE 3: Inferred from homology; KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane; KW Mitochondrion; Mitochondrion inner membrane; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1..227 FT /note="ATP synthase subunit a" FT /id="PRO_0000082157" FT TRANSMEM 14..34 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 69..89 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 98..118 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 139..159 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 165..185 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 189..209 FT /note="Helical" FT /evidence="ECO:0000255" SQ SEQUENCE 227 AA; 25250 MW; C08D61938B918A4C CRC64; MTLSFLDQFA SQSFLGIPLI AIAILIPWML FPSPYKRWMS NRLITFQSWF IARTTNQLML PLNTGAHKWA MILTALLLFL MTLNLLGLLP YTFTPTTQLS MNMALAVPLW LATVLIGMRN QPTHSLAHLL PEGTPTPLIP ILIIIETISL FIRPLALGVR LTANLTAGHL LIQLISTATF VMLSIMPTIA TLTFIVLALL TILEIAVAMI QAYVLVLLLS LYLQENV //