ID NU3M_PERMA Reviewed; 115 AA. AC Q95891; Q95894; Q95900; Q95902; Q95904; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 25-MAY-2022, entry version 71. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897}; DE EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897}; DE AltName: Full=NADH dehydrogenase subunit 3; GN Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3; OS Peromyscus maniculatus (North American deer mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; OC Cricetidae; Neotominae; Peromyscus. OX NCBI_TaxID=10042; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Austericus, Coolidgei, Interdictus, Oreas, and Rufinus; RA Hogan K.M., Davis S.K., Greenbaum I.F.; RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity of complex I. CC {ECO:0000250|UniProtKB:P03897}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000250|UniProtKB:P03897}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. Interacts with TMEM186. CC Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U40062; AAB17909.1; -; Genomic_DNA. DR EMBL; U40063; AAB17912.1; -; Genomic_DNA. DR EMBL; U40249; AAB17924.1; -; Genomic_DNA. DR EMBL; U40250; AAB17927.1; -; Genomic_DNA. DR EMBL; U40251; AAB17930.1; -; Genomic_DNA. DR AlphaFoldDB; Q95891; -. DR SMR; Q95891; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB. DR Gene3D; 1.20.58.1610; -; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR PANTHER; PTHR11058; PTHR11058; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; KW NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix; KW Transport; Ubiquinone. FT CHAIN 1..115 FT /note="NADH-ubiquinone oxidoreductase chain 3" FT /id="PRO_0000117796" FT TRANSMEM 4..24 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 55..75 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 84..104 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 15 FT /note="M -> T (in strain: Coolidgei)" FT VARIANT 20 FT /note="V -> I (in strain: Austericus and Rufinus)" FT VARIANT 42 FT /note="D -> E (in strain: Rufinus)" FT VARIANT 56 FT /note="F -> L (in strain: Oreas)" FT VARIANT 84 FT /note="I -> T (in strain: Coolidgei)" FT VARIANT 85 FT /note="D -> N (in strain: Austericus, Coolidgei and FT Rufinus)" FT VARIANT 104 FT /note="Y -> H (in strain: Rufinus)" SQ SEQUENCE 115 AA; 13181 MW; 61B275469729EBB5 CRC64; MNMLTALLVN ITLSMLLIIV AFWLPQLNLY TEKANPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ MYNIDIMMLT AFILVSVLAL GLAYEWLQKG LEWTE //