ID NU3M_PERMA Reviewed; 115 AA. AC Q95891; Q95894; Q95900; Q95902; Q95904; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 07-APR-2021, entry version 68. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3; DE EC=7.1.1.2; DE AltName: Full=NADH dehydrogenase subunit 3; GN Name=MT-ND3; Synonyms=MTND3, NADH3, ND3; OS Peromyscus maniculatus (North American deer mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; OC Cricetidae; Neotominae; Peromyscus. OX NCBI_TaxID=10042; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Austericus, Coolidgei, Interdictus, Oreas, and Rufinus; RA Hogan K.M., Davis S.K., Greenbaum I.F.; RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone (By CC similarity). {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass CC membrane protein {ECO:0000250}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U40062; AAB17909.1; -; Genomic_DNA. DR EMBL; U40063; AAB17912.1; -; Genomic_DNA. DR EMBL; U40249; AAB17924.1; -; Genomic_DNA. DR EMBL; U40250; AAB17927.1; -; Genomic_DNA. DR EMBL; U40251; AAB17930.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB. DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB. DR Gene3D; 1.20.58.1610; -; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR PANTHER; PTHR11058; PTHR11058; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Respiratory chain; KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone. FT CHAIN 1..115 FT /note="NADH-ubiquinone oxidoreductase chain 3" FT /id="PRO_0000117796" FT TRANSMEM 4..24 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 55..75 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 84..104 FT /note="Helical" FT /evidence="ECO:0000255" FT VARIANT 15 FT /note="M -> T (in strain: Coolidgei)" FT VARIANT 20 FT /note="V -> I (in strain: Austericus and Rufinus)" FT VARIANT 42 FT /note="D -> E (in strain: Rufinus)" FT VARIANT 56 FT /note="F -> L (in strain: Oreas)" FT VARIANT 84 FT /note="I -> T (in strain: Coolidgei)" FT VARIANT 85 FT /note="D -> N (in strain: Austericus, Coolidgei and FT Rufinus)" FT VARIANT 104 FT /note="Y -> H (in strain: Rufinus)" SQ SEQUENCE 115 AA; 13181 MW; 61B275469729EBB5 CRC64; MNMLTALLVN ITLSMLLIIV AFWLPQLNLY TEKANPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ MYNIDIMMLT AFILVSVLAL GLAYEWLQKG LEWTE //