ID NU3M_PERMA Reviewed; 115 AA. AC Q95891; Q95894; Q95900; Q95902; Q95904; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1998, sequence version 2. DT 03-OCT-2012, entry version 50. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3; DE EC=1.6.5.3; DE AltName: Full=NADH dehydrogenase subunit 3; GN Name=MT-ND3; Synonyms=MTND3, NADH3, ND3; OS Peromyscus maniculatus (North American deer mouse). OG Mitochondrion. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Cricetidae; Neotominae; Peromyscus. OX NCBI_TaxID=10042; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Austericus, Coolidgei, Interdictus, Oreas, and Rufinus; RA Hogan K.M., Davis S.K., Greenbaum I.F.; RL Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone (By similarity). CC -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol. CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane CC protein (By similarity). CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U40062; AAB17909.1; -; Genomic_DNA. DR EMBL; U40063; AAB17912.1; -; Genomic_DNA. DR EMBL; U40249; AAB17924.1; -; Genomic_DNA. DR EMBL; U40250; AAB17927.1; -; Genomic_DNA. DR EMBL; U40251; AAB17930.1; -; Genomic_DNA. DR HOVERGEN; HBG017392; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:EC. DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR PANTHER; PTHR11058; PTHR11058; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport; Membrane; Mitochondrion; NAD; Oxidoreductase; KW Respiratory chain; Transmembrane; Transmembrane helix; Transport; KW Ubiquinone. FT CHAIN 1 115 NADH-ubiquinone oxidoreductase chain 3. FT /FTId=PRO_0000117796. FT TRANSMEM 4 24 Helical; (Potential). FT TRANSMEM 55 75 Helical; (Potential). FT TRANSMEM 84 104 Helical; (Potential). FT VARIANT 15 15 M -> T (in strain: Coolidgei). FT VARIANT 20 20 V -> I (in strain: Austericus and FT Rufinus). FT VARIANT 42 42 D -> E (in strain: Rufinus). FT VARIANT 56 56 F -> L (in strain: Oreas). FT VARIANT 84 84 I -> T (in strain: Coolidgei). FT VARIANT 85 85 D -> N (in strain: Austericus, Coolidgei FT and Rufinus). FT VARIANT 104 104 Y -> H (in strain: Rufinus). SQ SEQUENCE 115 AA; 13181 MW; 61B275469729EBB5 CRC64; MNMLTALLVN ITLSMLLIIV AFWLPQLNLY TEKANPYECG FDPMGSARLP FSMKFFLVAI TFLLFDLEIA LLLPLPWAIQ MYNIDIMMLT AFILVSVLAL GLAYEWLQKG LEWTE //