ID Q957Y1_ANODD Unreviewed; 116 AA. AC Q957Y1; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 22-FEB-2023, entry version 83. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU003640}; GN Name=ND3 {ECO:0000313|EMBL:QEX95993.1}; OS Anomalopteryx didiformis (Little bush moa). OG Mitochondrion {ECO:0000313|EMBL:AAK53336.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Palaeognathae; Dinornithiformes; Emeidae; OC Anomalopteryx. OX NCBI_TaxID=8811 {ECO:0000313|EMBL:AAK53336.1}; RN [1] {ECO:0000313|EMBL:AAK53336.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11370967; DOI=10.1098/rspb.2001.1587; RA Haddrath O., Baker A.J.; RT "Complete mitochondrial DNA genome sequences of extinct birds: ratite RT phylogenetics and the vicariance biogeography hypothesis."; RL Proc. R. Soc. B 268:939-945(2001). RN [2] {ECO:0000313|EMBL:QEX95993.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Bone {ECO:0000313|EMBL:QEX95993.1}; RA Cloutier A., Sackton T.B., Grayson P., Edwards S.V., Baker A.J.; RT "First nuclear genome assembly of an extinct moa species, the little bush RT moa (Anomalopteryx didiformis)."; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity of complex I. CC {ECO:0000256|RuleBase:RU003640}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003640}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003640}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF338714; AAK53336.1; -; Genomic_DNA. DR EMBL; MK778441; QEX95993.1; -; Genomic_DNA. DR PIR; H90622; H90622. DR RefSeq; NP_115370.1; NC_002779.1. DR AlphaFoldDB; Q957Y1; -. DR GeneID; 803294; -. DR CTD; 4537; -. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR PANTHER; PTHR11058; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1. DR PANTHER; PTHR11058:SF9; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3; 1. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003640}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:AAK53336.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640}; KW Respiratory chain {ECO:0000256|RuleBase:RU003640}; KW Translocase {ECO:0000256|RuleBase:RU003640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003640}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003640}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640}. FT TRANSMEM 52..74 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" FT TRANSMEM 86..105 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" SQ SEQUENCE 116 AA; 13331 MW; 0CBD1BDBAC8B9631 CRC64; MNMVTFMLLL SFTLCTILTT INFWLAQMNP DTEKLSPYEC GFDPLGSARL PFSIRFFLMA ILFLLFDLEI ALLLPLPWAI QLPQPLLTLL WTSMILLLLT LGLAYEWMQG GLEWAE //