ID GLYK_ARATH Reviewed; 456 AA. AC Q944I4; A8MQE0; Q8LFL2; Q9C5L9; Q9C967; DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot. DT 30-AUG-2005, sequence version 2. DT 28-MAR-2018, entry version 110. DE RecName: Full=D-glycerate 3-kinase, chloroplastic {ECO:0000305}; DE Short=AtGLYK {ECO:0000303|PubMed:15980259}; DE EC=2.7.1.31 {ECO:0000269|PubMed:15980259}; DE Flags: Precursor; GN Name=GLYK {ECO:0000303|PubMed:15980259}; GN OrderedLocusNames=At1g80380 {ECO:0000312|Araport:AT1G80380}; GN ORFNames=F5I6.13 {ECO:0000312|EMBL:AAG52441.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130712; DOI=10.1038/35048500; RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.; RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis RT thaliana."; RL Nature 408:816-820(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Portal (Araport); RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., RA Feldmann K.A.; RT "Full-length cDNA from Arabidopsis thaliana."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP CATALYTIC ACTIVITY, IDENTIFICATION BY MASS SPECTROMETRY, AND FUNCTION. RX PubMed=15980259; DOI=10.1105/tpc.105.033993; RA Boldt R., Edner C., Kolukisaoglu U., Hagemann M., Weckwerth W., RA Wienkoop S., Morgenthal K., Bauwe H.; RT "D-glycerate 3-kinase, the last unknown enzyme in the photorespiratory RT cycle in Arabidopsis, belongs to a novel kinase family."; RL Plant Cell 17:2413-2420(2005). RN [6] RP FUNCTION (ISOFORM 3), SUBCELLULAR LOCATION (ISOFORMS 1 AND 3), RP ALTERNATIVE SPLICING, AND INDUCTION. RX PubMed=29129375; DOI=10.1016/j.cell.2017.10.018; RA Ushijima T., Hanada K., Gotoh E., Yamori W., Kodama Y., Tanaka H., RA Kusano M., Fukushima A., Tokizawa M., Yamamoto Y.Y., Tada Y., RA Suzuki Y., Matsushita T.; RT "Light controls protein localization through phytochrome-mediated RT alternative promoter selection."; RL Cell 0:0-0(2017). CC -!- FUNCTION: Catalyzes the concluding reaction of the CC photorespiratory C2 cycle, an indispensable ancillary metabolic CC pathway to the photosynthetic C3 cycle that enables land plants to CC grow in an oxygen-containing atmosphere. CC {ECO:0000269|PubMed:15980259}. CC -!- FUNCTION: Isoform 3: Cytoplasmic D-glycerate 3-kinase that CC constitutes a photorespiratory bypass that alleviates fluctuating CC light-induced photoinhibition (PubMed:29129375). CC {ECO:0000269|PubMed:29129375}. CC -!- CATALYTIC ACTIVITY: ATP + D-glycerate = ADP + 3-phospho-D- CC glycerate. {ECO:0000269|PubMed:15980259}. CC -!- PATHWAY: Photosynthesis; photorespiration; 3-phospho-D-glycerate CC from glycine: step 4/4. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Isoform 1: Plastid, chloroplast CC {ECO:0000269|PubMed:29129375}. Note=Expressed in the light. CC {ECO:0000269|PubMed:29129375}. CC -!- SUBCELLULAR LOCATION: Isoform 3: Cytoplasm CC {ECO:0000269|PubMed:29129375}. Note=Expressed in the dark. CC {ECO:0000269|PubMed:29129375}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q944I4-1; Sequence=Displayed; CC Note=Expressed in the light. {ECO:0000269|PubMed:29129375}; CC Name=2; CC IsoId=Q944I4-2; Sequence=VSP_015208; CC Note=No experimental confirmation available.; CC Name=3; CC IsoId=Q944I4-3; Sequence=VSP_059299; CC Note=Expressed in the dark. {ECO:0000269|PubMed:29129375}; CC -!- INDUCTION: Isoform 1: Expressed in the light (PubMed:29129375). CC Isoform 3: Expressed in the dark (PubMed:29129375). CC {ECO:0000269|PubMed:29129375}. CC -!- SIMILARITY: Belongs to the GLYK kinase family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAG52441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC018848; AAG52441.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002684; AEE36393.1; -; Genomic_DNA. DR EMBL; CP002684; AEE36394.1; -; Genomic_DNA. DR EMBL; CP002684; AEE36395.1; -; Genomic_DNA. DR EMBL; AF360156; AAK25866.1; -; mRNA. DR EMBL; AF428401; AAL16169.1; -; mRNA. DR EMBL; AY056310; AAL07159.1; -; mRNA. DR EMBL; AY084779; AAM61346.1; -; mRNA. DR PIR; E96835; E96835. DR RefSeq; NP_001077855.1; NM_001084386.2. [Q944I4-3] DR RefSeq; NP_565237.1; NM_106687.2. [Q944I4-2] DR RefSeq; NP_849912.1; NM_179581.3. [Q944I4-1] DR UniGene; At.24938; -. DR ProteinModelPortal; Q944I4; -. DR SMR; Q944I4; -. DR STRING; 3702.AT1G80380.2; -. DR iPTMnet; Q944I4; -. DR PaxDb; Q944I4; -. DR PRIDE; Q944I4; -. DR EnsemblPlants; AT1G80380.1; AT1G80380.1; AT1G80380. [Q944I4-2] DR EnsemblPlants; AT1G80380.2; AT1G80380.2; AT1G80380. [Q944I4-1] DR EnsemblPlants; AT1G80380.3; AT1G80380.3; AT1G80380. [Q944I4-3] DR GeneID; 844378; -. DR Gramene; AT1G80380.1; AT1G80380.1; AT1G80380. [Q944I4-2] DR Gramene; AT1G80380.2; AT1G80380.2; AT1G80380. [Q944I4-1] DR Gramene; AT1G80380.3; AT1G80380.3; AT1G80380. [Q944I4-3] DR KEGG; ath:AT1G80380; -. DR Araport; AT1G80380; -. DR TAIR; locus:2034260; AT1G80380. DR eggNOG; KOG2878; Eukaryota. DR eggNOG; COG4240; LUCA. DR HOGENOM; HOG000170906; -. DR InParanoid; Q944I4; -. DR KO; K15918; -. DR OMA; SSTWPEV; -. DR OrthoDB; EOG093609ZN; -. DR PhylomeDB; Q944I4; -. DR BioCyc; ARA:AT1G80380-MONOMER; -. DR BioCyc; MetaCyc:AT1G80380-MONOMER; -. DR BRENDA; 2.7.1.31; 399. DR UniPathway; UPA00951; UER00917. DR PRO; PR:Q944I4; -. DR Proteomes; UP000006548; Chromosome 1. DR ExpressionAtlas; Q944I4; baseline and differential. DR Genevisible; Q944I4; AT. DR GO; GO:0009507; C:chloroplast; IDA:UniProtKB. DR GO; GO:0009941; C:chloroplast envelope; IDA:TAIR. DR GO; GO:0009570; C:chloroplast stroma; IDA:TAIR. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0008887; F:glycerate kinase activity; IDA:TAIR. DR GO; GO:0004849; F:uridine kinase activity; IBA:GO_Central. DR GO; GO:0009854; P:oxidative photosynthetic carbon pathway; IEA:UniProtKB-UniPathway. DR GO; GO:0009853; P:photorespiration; IMP:TAIR. DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IBA:GO_Central. DR GO; GO:0043097; P:pyrimidine nucleoside salvage; IBA:GO_Central. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR006083; PRK/URK. DR Pfam; PF00485; PRK; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 1: Evidence at protein level; KW Alternative splicing; ATP-binding; Chloroplast; Complete proteome; KW Cytoplasm; Glycolate pathway; Kinase; Nucleotide-binding; KW Photorespiration; Plastid; Reference proteome; Transferase; KW Transit peptide. FT TRANSIT 1 63 Chloroplast. {ECO:0000255}. FT CHAIN 64 456 D-glycerate 3-kinase, chloroplastic. FT /FTId=PRO_0000012282. FT NP_BIND 215 222 ATP. {ECO:0000255}. FT VAR_SEQ 1 92 Missing (in isoform 3). FT /FTId=VSP_059299. FT VAR_SEQ 206 299 Missing (in isoform 2). {ECO:0000305}. FT /FTId=VSP_015208. FT CONFLICT 188 188 W -> C (in Ref. 4; AAM61346). FT {ECO:0000305}. FT CONFLICT 239 239 S -> P (in Ref. 3; AAL16169). FT {ECO:0000305}. SQ SEQUENCE 456 AA; 51018 MW; 5961E0FC6E2220FB CRC64; MAVAISGSSL ISSTLQHYNN RIYIRDYPIP CHSSNPICNS FNFKRRSFSP SSPKFNDHVV NPSSSYLSSK LSPIRTHSSF AACGCSWIQD NSMVHDYATT TNGTSKRCSA LPTTNTVDVS SVSDLFEFIC SGPLVNKIGI TPQRVGQSID KWLLYGSQLC RLFQLNELKL TIPQKARLYH YYIPVFIWCE DQIALHNSKF KDGDDVPPLV IGFSAPQGCG KTTLVFALDY LFKTTKKKSA TISVDDFYLT AEGQAELRKK NPGNALLEYR GNAGSHDLKL SVETLEALSK LTKEGLKMKV PRYNKSAYSG RGDRADSSTW PEVEGPLSVI LFEGWMLGFK PLPADVVKAV DPQLEVVNKN LEAYYDAWDK YIDAWVVIKI QDPSYVYRWR LQAEIAMRQD GQAGMSDEEV NDFVSRYLPA YKAYLPTLYA EGPSGSDPDR VLAIDIDEER NPILAN //