ID   DCUP1_ARATH             Reviewed;         418 AA.
AC   Q93ZB6; Q9LKB1;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 2.
DT   29-MAY-2013, entry version 79.
DE   RecName: Full=Uroporphyrinogen decarboxylase 1, chloroplastic;
DE            Short=UPD1;
DE            Short=URO-D1;
DE            EC=4.1.1.37;
DE   Flags: Precursor;
GN   OrderedLocusNames=At3g14930; ORFNames=K15M2.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II.
RT   Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC
RT   and BAC clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Resource (TAIR);
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G.,
RA   Caboche M., Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome
RT   annotation.";
RL   Genome Res. 14:406-413(2004).
CC   -!- FUNCTION: Catalyzes the decarboxylation of four acetate groups of
CC       uroporphyrinogen-III to yield coproporphyrinogen-III (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Uroporphyrinogen III = coproporphyrinogen + 4
CC       CO(2).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate:
CC       step 4/4.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q93ZB6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q93ZB6-2; Sequence=VSP_037402;
CC         Note=May be due to a competing acceptor splice site. No
CC         experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BX824686; Type=Miscellaneous discrepancy; Note=Sequencing errors;
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DR   EMBL; AP000370; BAA97056.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75589.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75590.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE75591.1; -; Genomic_DNA.
DR   EMBL; AY057663; AAL15294.1; -; mRNA.
DR   EMBL; AY136476; AAM97141.1; -; mRNA.
DR   EMBL; BT008826; AAP68265.1; -; mRNA.
DR   EMBL; BX824686; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00524385; -.
DR   IPI; IPI00524782; -.
DR   RefSeq; NP_566495.1; NM_112355.2.
DR   RefSeq; NP_850587.1; NM_180256.1.
DR   RefSeq; NP_974316.1; NM_202587.1.
DR   UniGene; At.6655; -.
DR   ProteinModelPortal; Q93ZB6; -.
DR   SMR; Q93ZB6; 58-399.
DR   STRING; 3702.AT3G14930.1-P; -.
DR   PaxDb; Q93ZB6; -.
DR   PRIDE; Q93ZB6; -.
DR   EnsemblPlants; AT3G14930.1; AT3G14930.1; AT3G14930.
DR   EnsemblPlants; AT3G14930.2; AT3G14930.2; AT3G14930.
DR   GeneID; 820722; -.
DR   KEGG; ath:AT3G14930; -.
DR   TAIR; At3g14930; -.
DR   eggNOG; COG0407; -.
DR   HOGENOM; HOG000253896; -.
DR   InParanoid; Q93ZB6; -.
DR   KO; K01599; -.
DR   OMA; QAGRYHK; -.
DR   PhylomeDB; Q93ZB6; -.
DR   ProtClustDB; PLN02433; -.
DR   UniPathway; UPA00251; UER00321.
DR   Genevestigator; Q93ZB6; -.
DR   GO; GO:0009570; C:chloroplast stroma; IDA:TAIR.
DR   GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:EC.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046686; P:response to cadmium ion; IEP:TAIR.
DR   InterPro; IPR006361; Uroporphyrinogen_deCO2ase_HemE.
DR   InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR   PANTHER; PTHR21091:SF2; PTHR21091:SF2; 1.
DR   Pfam; PF01208; URO-D; 1.
DR   TIGRFAMs; TIGR01464; hemE; 1.
DR   PROSITE; PS00906; UROD_1; 1.
DR   PROSITE; PS00907; UROD_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chlorophyll biosynthesis; Chloroplast;
KW   Complete proteome; Decarboxylase; Lyase; Plastid;
KW   Porphyrin biosynthesis; Reference proteome; Transit peptide.
FT   TRANSIT       1      ?       Chloroplast (Potential).
FT   CHAIN         ?    418       Uroporphyrinogen decarboxylase 1,
FT                                chloroplastic.
FT                                /FTId=PRO_0000376071.
FT   REGION       80     84       Substrate binding (By similarity).
FT   BINDING      99     99       Substrate (By similarity).
FT   BINDING     129    129       Substrate (By similarity).
FT   BINDING     130    130       Substrate (By similarity).
FT   BINDING     206    206       Substrate (By similarity).
FT   BINDING     261    261       Substrate (By similarity).
FT   BINDING     376    376       Substrate (By similarity).
FT   SITE        130    130       Transition state stabilizer (By
FT                                similarity).
FT   VAR_SEQ       1     77       Missing (in isoform 2).
FT                                /FTId=VSP_037402.
FT   CONFLICT     36     36       V -> G (in Ref. 3; AAL15294).
SQ   SEQUENCE   418 AA;  46254 MW;  F8A78980A6B08CB2 CRC64;
     MSLSSPTSAC SSSRCYSSGL SFPIGFGSNP INVGLVCYPK RYSIAARKFV VACSSSSSDP
     LLVKAAKGQA ISRPPAWMMR QAGRYMAVYQ KLAKKHPSFR ERSENTDLIV EISLQPWQAF
     RPDGVIIFSD ILTPLPAFGV PFDIEEVKGP VIQSPIRTEE DMKRLHPIDF EKLQFVGDSL
     KILRREVGEH AAVLGFVGAP WTIATYIVEG GTTRTYTVIK NMCHTAPDVL RALLSHLTKA
     ITEYVVYQVE HGAHCIQIFD SWGGQLTPEM WERWSKPYIE EIIHAVKKRC PDTPIVFYIN
     GNGGLLERMK GTGADVIGLD WTVDMADGRR RLGSEVSVQG NVDPAYLFSP LPALTEEIER
     VVKCAGPKGH ILNLGHGVLV GTPEEAVAHF FETARNLDYQ TLFQNHVPAE KAEPELVV
//