ID PYRG_FIBSU STANDARD; PRT; 133 AA. AC Q939R0; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE CTP synthase (EC 6.3.4.2) (UTP--ammonia ligase) (CTP synthetase) DE (Fragment). GN Name=pyrG; OS Fibrobacter succinogenes (Bacteroides succinogenes). OC Bacteria; Fibrobacteres; Fibrobacterales; Fibrobacteraceae; OC Fibrobacter. OX NCBI_TaxID=833; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=S85 / ATCC 19169; RX MEDLINE=21427455; PubMed=11535801; RA Griffiths E., Gupta R.S.; RT "The use of signature sequences in different proteins to determine the RT relative branching order of bacterial divisions: evidence that RT Fibrobacter diverged at a similar time to Chlamydia and the Cytophaga- RT Flavobacterium-Bacteroides division."; RL Microbiology 147:2611-2622(2001). CC -!- FUNCTION: Catalyzes the ATP-dependent amination of UTP to CTP with CC either L-glutamine or ammonia as the source of nitrogen (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + UTP + NH(3) = ADP + phosphate + CTP. CC -!- ENZYME REGULATION: Allosterically activated by GTP, when glutamine CC is the substrate. Inhibited by CTP (By similarity). CC -!- PATHWAY: Pyrimidine biosynthesis; conversion of UMP to CTP; third CC (last) step. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SIMILARITY: Belongs to the CTP synthase family. CC -!- SIMILARITY: Contains 1 type-1 glutamine amidotransferase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY017383; AAK13023.1; -; Genomic_DNA. DR HAMAP; MF_01227; -; 1. DR InterPro; IPR000991; GATase_1. DR Pfam; PF00117; GATase; 1. DR PROSITE; PS00442; GATASE_TYPE_I; PARTIAL. KW Glutamine amidotransferase; Ligase; Pyrimidine biosynthesis. FT REGION <1 >133 Glutamine amidotransferase. FT ACT_SITE 3 3 GATase (By similarity). FT ACT_SITE 131 131 GATase (By similarity). FT ACT_SITE 133 133 GATase (By similarity). FT NON_TER 1 1 FT NON_TER 133 133 SQ SEQUENCE 133 AA; 15322 MW; 40554D2944D78123 CRC64; GICLGMQMLA IEFARNVLGL KVANSTEFDE NTTPRFIRDL EEQKDGHDKG GTMRLGLYPC KLAKDSNAAN VYKREKITER HRHRYEFNYN SEFRKELEKA GLKIAGTSPD GKLVEMVELK NHPYFEACQF HPE //