ID CCMA_RICCN Reviewed; 191 AA. AC Q92G95; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2004, sequence version 2. DT 13-NOV-2013, entry version 71. DE RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA; DE EC=3.6.3.41; DE AltName: Full=Heme exporter protein A; GN Name=ccmA; OrderedLocusNames=RC1228; OS Rickettsia conorii (strain ATCC VR-613 / Malish 7). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group. OX NCBI_TaxID=272944; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC VR-613 / Malish 7; RX PubMed=11557893; DOI=10.1126/science.1061471; RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., RA Raoult D.; RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii."; RL Science 293:2093-2098(2001). CC -!- FUNCTION: Part of the ABC transporter complex CcmAB involved in CC the biogenesis of c-type cytochromes; once thought to export heme, CC this seems not to be the case, but its exact role is uncertain. CC Responsible for energy coupling to the transport system (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + H(2)O + heme(In) = ADP + phosphate + CC heme(Out). CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins CC (CcmA) and two transmembrane proteins (CcmB) (By similarity). CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane CC protein (By similarity). CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. CcmA CC exporter (TC 3.A.1.107) family. CC -!- SIMILARITY: Contains 1 ABC transporter domain. CC -!- SEQUENCE CAUTION: CC Sequence=AAL03766.1; Type=Erroneous initiation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE006914; AAL03766.1; ALT_INIT; Genomic_DNA. DR PIR; D97853; D97853. DR RefSeq; NP_360865.1; NC_003103.1. DR ProteinModelPortal; Q92G95; -. DR STRING; 272944.RC1228; -. DR EnsemblBacteria; AAL03766; AAL03766; RC1228. DR GeneID; 928380; -. DR KEGG; rco:RC1228; -. DR PATRIC; 17889952; VBIRicCon45613_1407. DR eggNOG; COG4133; -. DR KO; K02193; -. DR OMA; SSGHIYY; -. DR OrthoDB; EOG6SNDS1; -. DR ProtClustDB; PRK13541; -. DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0015439; F:heme-transporting ATPase activity; IEA:UniProtKB-EC. DR GO; GO:0006200; P:ATP catabolic process; IEA:GOC. DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR005895; ABC_transptr_haem_export_CcmA. DR InterPro; IPR027417; P-loop_NTPase. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR01189; ccmA; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; FALSE_NEG. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. DR PROSITE; PS51243; CCMA; 1. PE 3: Inferred from homology; KW ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; KW Cytochrome c-type biogenesis; Hydrolase; Membrane; Nucleotide-binding; KW Transport. FT CHAIN 1 191 Cytochrome c biogenesis ATP-binding FT export protein CcmA. FT /FTId=PRO_0000092206. FT DOMAIN 2 190 ABC transporter. FT NP_BIND 29 36 ATP (Potential). SQ SEQUENCE 191 AA; 21427 MW; D8C69C94FDB9AAB8 CRC64; MLSLHQLQFK NLFDLNITFL PSSITYIKGA NGCGKSSLLR MIAGIMQPSS GHIYYRNCNI NNIAKLYCTY IGHNLGLKSE MTVFENLKFW SEIYNSAATV YAAIHYFKLH DLLDKKCYSL SSGMQKIVAI ARLIACQSDL WLLDEVETNL SKENRALLNN LIVMKANSGG IVLLSSHLES SIKSAQILRI D //