ID CCMA_RICCN Reviewed; 191 AA. AC Q92G95; DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot. DT 24-MAY-2004, sequence version 2. DT 14-DEC-2022, entry version 111. DE RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA {ECO:0000255|HAMAP-Rule:MF_01707}; DE EC=7.6.2.5 {ECO:0000255|HAMAP-Rule:MF_01707}; DE AltName: Full=Heme exporter protein A {ECO:0000255|HAMAP-Rule:MF_01707}; GN Name=ccmA {ECO:0000255|HAMAP-Rule:MF_01707}; OrderedLocusNames=RC1228; OS Rickettsia conorii (strain ATCC VR-613 / Malish 7). OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group. OX NCBI_TaxID=272944; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC VR-613 / Malish 7; RX PubMed=11557893; DOI=10.1126/science.1061471; RA Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V., RA Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.; RT "Mechanisms of evolution in Rickettsia conorii and R. prowazekii."; RL Science 293:2093-2098(2001). CC -!- FUNCTION: Part of the ABC transporter complex CcmAB involved in the CC biogenesis of c-type cytochromes; once thought to export heme, this CC seems not to be the case, but its exact role is uncertain. Responsible CC for energy coupling to the transport system. {ECO:0000255|HAMAP- CC Rule:MF_01707}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate; CC Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344, CC ChEBI:CHEBI:456216; EC=7.6.2.5; Evidence={ECO:0000255|HAMAP- CC Rule:MF_01707}; CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (CcmA) and CC two transmembrane proteins (CcmB). {ECO:0000255|HAMAP-Rule:MF_01707}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP- CC Rule:MF_01707}; Peripheral membrane protein {ECO:0000255|HAMAP- CC Rule:MF_01707}. CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. CcmA exporter CC (TC 3.A.1.107) family. {ECO:0000255|HAMAP-Rule:MF_01707}. CC -!- SEQUENCE CAUTION: CC Sequence=AAL03766.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE006914; AAL03766.1; ALT_INIT; Genomic_DNA. DR PIR; D97853; D97853. DR AlphaFoldDB; Q92G95; -. DR SMR; Q92G95; -. DR EnsemblBacteria; AAL03766; AAL03766; RC1228. DR KEGG; rco:RC1228; -. DR PATRIC; fig|272944.4.peg.1407; -. DR HOGENOM; CLU_000604_1_2_5; -. DR OMA; GITHLPF; -. DR Proteomes; UP000000816; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015439; F:ABC-type heme transporter activity; IEA:UniProtKB-EC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.300; -; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR003439; ABC_transporter-like_ATP-bd. DR InterPro; IPR005895; ABC_transptr_haem_export_CcmA. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR43499; ABC TRANSPORTER I FAMILY MEMBER 1; 1. DR Pfam; PF00005; ABC_tran; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR TIGRFAMs; TIGR01189; ccmA; 1. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1. DR PROSITE; PS51243; CCMA; 1. PE 3: Inferred from homology; KW ATP-binding; Cell inner membrane; Cell membrane; KW Cytochrome c-type biogenesis; Membrane; Nucleotide-binding; Translocase; KW Transport. FT CHAIN 1..191 FT /note="Cytochrome c biogenesis ATP-binding export protein FT CcmA" FT /id="PRO_0000092206" FT DOMAIN 2..190 FT /note="ABC transporter" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01707" FT BINDING 29..36 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01707" SQ SEQUENCE 191 AA; 21427 MW; D8C69C94FDB9AAB8 CRC64; MLSLHQLQFK NLFDLNITFL PSSITYIKGA NGCGKSSLLR MIAGIMQPSS GHIYYRNCNI NNIAKLYCTY IGHNLGLKSE MTVFENLKFW SEIYNSAATV YAAIHYFKLH DLLDKKCYSL SSGMQKIVAI ARLIACQSDL WLLDEVETNL SKENRALLNN LIVMKANSGG IVLLSSHLES SIKSAQILRI D //