ID   COR2A_HUMAN             Reviewed;         525 AA.
AC   Q92828; Q5TBR5; Q92829; Q9BWS5;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   12-FEB-2003, sequence version 2.
DT   02-OCT-2024, entry version 195.
DE   RecName: Full=Coronin-2A;
DE   AltName: Full=IR10;
DE   AltName: Full=WD repeat-containing protein 2;
GN   Name=CORO2A; Synonyms=IR10, WDR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epidermis;
RX   PubMed=8985118; DOI=10.1089/dna.1996.15.1049;
RA   Zaphiropoulos P.G., Toftgard R.;
RT   "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3
RT   chromosomal region.";
RL   DNA Cell Biol. 15:1049-1056(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   COMPONENT OF THE N-COR COMPLEX WITH TBL1R; TBL1X AND HDAC3.
RX   PubMed=12628926; DOI=10.1093/emboj/cdg120;
RA   Yoon H.-G., Chan D.W., Huang Z.-Q., Li J., Fondell J.D., Qin J., Wong J.;
RT   "Purification and functional characterization of the human N-CoR complex:
RT   the roles of HDAC3, TBL1 and TBLR1.";
RL   EMBO J. 22:1336-1346(2003).
CC   -!- SUBUNIT: Binds actin (By similarity). Component of the N-Cor repressor
CC       complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A
CC       and GPS2. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q92828; Q9NYF8: BCLAF1; NbExp=3; IntAct=EBI-2835660, EBI-437804;
CC       Q92828; Q16595: FXN; NbExp=3; IntAct=EBI-2835660, EBI-949340;
CC       Q92828; Q99732: LITAF; NbExp=3; IntAct=EBI-2835660, EBI-725647;
CC       Q92828; P55055: NR1H2; NbExp=4; IntAct=EBI-2835660, EBI-745354;
CC   -!- SIMILARITY: Belongs to the WD repeat coronin family. {ECO:0000305}.
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DR   EMBL; U57057; AAB47807.1; -; mRNA.
DR   EMBL; U57058; AAB47808.1; -; mRNA.
DR   EMBL; AL137073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471105; EAW58879.1; -; Genomic_DNA.
DR   EMBL; BC000010; AAH00010.1; -; mRNA.
DR   EMBL; BC011690; AAH11690.1; -; mRNA.
DR   CCDS; CCDS6735.1; -.
DR   RefSeq; NP_003380.3; NM_003389.3.
DR   RefSeq; NP_438171.1; NM_052820.3.
DR   RefSeq; XP_011517288.1; XM_011518986.2.
DR   AlphaFoldDB; Q92828; -.
DR   SMR; Q92828; -.
DR   BioGRID; 113302; 73.
DR   CORUM; Q92828; -.
DR   DIP; DIP-59202N; -.
DR   IntAct; Q92828; 64.
DR   MINT; Q92828; -.
DR   STRING; 9606.ENSP00000343746; -.
DR   GlyGen; Q92828; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q92828; -.
DR   PhosphoSitePlus; Q92828; -.
DR   BioMuta; CORO2A; -.
DR   DMDM; 28381354; -.
DR   jPOST; Q92828; -.
DR   MassIVE; Q92828; -.
DR   PaxDb; 9606-ENSP00000343746; -.
DR   PeptideAtlas; Q92828; -.
DR   ProteomicsDB; 75505; -.
DR   Pumba; Q92828; -.
DR   Antibodypedia; 48737; 111 antibodies from 20 providers.
DR   DNASU; 7464; -.
DR   Ensembl; ENST00000343933.9; ENSP00000343746.5; ENSG00000106789.13.
DR   Ensembl; ENST00000375077.5; ENSP00000364218.4; ENSG00000106789.13.
DR   GeneID; 7464; -.
DR   KEGG; hsa:7464; -.
DR   MANE-Select; ENST00000375077.5; ENSP00000364218.4; NM_052820.4; NP_438171.1.
DR   UCSC; uc004ayl.4; human.
DR   AGR; HGNC:2255; -.
DR   CTD; 7464; -.
DR   DisGeNET; 7464; -.
DR   GeneCards; CORO2A; -.
DR   HGNC; HGNC:2255; CORO2A.
DR   HPA; ENSG00000106789; Tissue enhanced (intestine).
DR   MIM; 602159; gene.
DR   neXtProt; NX_Q92828; -.
DR   OpenTargets; ENSG00000106789; -.
DR   PharmGKB; PA26771; -.
DR   VEuPathDB; HostDB:ENSG00000106789; -.
DR   eggNOG; KOG0303; Eukaryota.
DR   GeneTree; ENSGT00940000155598; -.
DR   HOGENOM; CLU_026859_4_0_1; -.
DR   InParanoid; Q92828; -.
DR   OMA; GIXPVLV; -.
DR   OrthoDB; 5474889at2759; -.
DR   PhylomeDB; Q92828; -.
DR   TreeFam; TF314280; -.
DR   PathwayCommons; Q92828; -.
DR   SignaLink; Q92828; -.
DR   BioGRID-ORCS; 7464; 11 hits in 1158 CRISPR screens.
DR   ChiTaRS; CORO2A; human.
DR   GeneWiki; CORO2A; -.
DR   GenomeRNAi; 7464; -.
DR   Pharos; Q92828; Tbio.
DR   PRO; PR:Q92828; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q92828; protein.
DR   Bgee; ENSG00000106789; Expressed in jejunal mucosa and 158 other cell types or tissues.
DR   ExpressionAtlas; Q92828; baseline and differential.
DR   GO; GO:0017053; C:transcription repressor complex; IDA:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR015505; Coronin.
DR   InterPro; IPR015048; DUF1899.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10856; CORONIN; 1.
DR   PANTHER; PTHR10856:SF2; CORONIN-2A; 1.
DR   Pfam; PF08953; DUF1899; 1.
DR   Pfam; PF00400; WD40; 3.
DR   Pfam; PF16300; WD40_4; 1.
DR   SMART; SM01166; DUF1899; 1.
DR   SMART; SM01167; DUF1900; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; Coiled coil; Proteomics identification; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..525
FT                   /note="Coronin-2A"
FT                   /id="PRO_0000050928"
FT   REPEAT          24..71
FT                   /note="WD 1"
FT   REPEAT          72..122
FT                   /note="WD 2"
FT   REPEAT          123..170
FT                   /note="WD 3"
FT   REPEAT          171..214
FT                   /note="WD 4"
FT   REPEAT          215..259
FT                   /note="WD 5"
FT   REPEAT          260..305
FT                   /note="WD 6"
FT   REPEAT          306..342
FT                   /note="WD 7"
FT   COILED          485..524
FT                   /evidence="ECO:0000255"
FT   VARIANT         296
FT                   /note="R -> H (in dbSNP:rs2231666)"
FT                   /id="VAR_053390"
FT   VARIANT         495
FT                   /note="R -> L (in dbSNP:rs35787916)"
FT                   /id="VAR_053391"
FT   CONFLICT        59
FT                   /note="A -> G (in Ref. 1; AAB47807)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="V -> A (in Ref. 1; AAB47808)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        360
FT                   /note="R -> G (in Ref. 1; AAB47807)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        373
FT                   /note="A -> G (in Ref. 1; AAB47807)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   525 AA;  59763 MW;  8546E1C5A78CB1FA CRC64;
     MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF
     LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS CSEDATIKIW SIPKQLLTRN
     LTAYRKELVG HARRVGLVEW HPTAANILFS AGYDYKVMIW NLDTKESVIT SPMSTISCHQ
     DVILSMSFNT NGSLLATTCK DRKIRVIDPR AGTVLQEASY KGHRASKVLF LGNLKKLMST
     GTSRWNNRQV ALWDQDNLSV PLMEEDLDGS SGVLFPFYDA DTSMLYVVGK GDGNIRYYEV
     SADKPHLSYL TEYRSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI EPISMIVPRR
     SESYQEDIYP PTAGAQPSLT AQEWLSGMNR DPILVSLRPG SELLRPHPLP AERPIFNSMA
     PASPRLLNQT EKLAAEDGWR SSSLLEEKMP RWAAEHRLEE KKTWLTNGFD VFECPPPKTE
     NELLQMFYRQ QEEIRRLREL LTQREVQAKQ LELEIKNLRM GSEQL
//