ID   N42L2_HUMAN             Reviewed;         583 AA.
AC   Q92802; A3KME8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   14-DEC-2022, entry version 171.
DE   RecName: Full=NEDD4-binding protein 2-like 2;
DE   AltName: Full=Phosphonoformate immuno-associated protein 5;
GN   Name=N4BP2L2; Synonyms=CG005, PFAAP5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=8812419; DOI=10.1006/geno.1996.0428;
RA   Couch F.J., Rommens J.M., Neuhausen S.L., Belanger C., Dumont M.,
RA   Kenneth A., Bell R., Berry S., Bogden R., Cannon-Albright L., Farid L.,
RA   Frye C., Hattier T., Janecki T., Jiang P., Kehrer R., Leblanc J.F.,
RA   McArthur-Morrison J., McSweeney D., Miki Y., Peng Y., Samson C.,
RA   Schroeder M., Snyder S.C., Stringfellow M., Stroup C., Swedlund B.,
RA   Swensen J., Teng D., Thakur S., Tran T., Tranchant M., Welver-Feldhaus J.,
RA   Wong A.K.C., Shizuya H., Labrie F., Skolnick M.H., Goldgar D.E., Kamb A.,
RA   Weber B.L., Tavtigian S.V., Simard J.;
RT   "Generation of an integrated transcription map of the BRCA2 region on
RT   chromosome 13q12-q13.";
RL   Genomics 36:86-99(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Liu Y., Cheng J., Lu Y.;
RT   "Screening and cloning of a new immuno-associated gene regulated by
RT   phosphonoformate.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Rhodes S.;
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 434-583 (ISOFORM 2).
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX   PubMed=16344560; DOI=10.1101/gr.4039406;
RA   Kimura K., Wakamatsu A., Suzuki Y., Ota T., Nishikawa T., Yamashita R.,
RA   Yamamoto J., Sekine M., Tsuritani K., Wakaguri H., Ishii S., Sugiyama T.,
RA   Saito K., Isono Y., Irie R., Kushida N., Yoneyama T., Otsuka R., Kanda K.,
RA   Yokoi T., Kondo H., Wagatsuma M., Murakawa K., Ishida S., Ishibashi T.,
RA   Takahashi-Fujii A., Tanase T., Nagai K., Kikuchi H., Nakai K., Isogai T.,
RA   Sugano S.;
RT   "Diversification of transcriptional modulation: large-scale identification
RT   and characterization of putative alternative promoters of human genes.";
RL   Genome Res. 16:55-65(2006).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- INTERACTION:
CC       Q92802; P49639: HOXA1; NbExp=3; IntAct=EBI-2514973, EBI-740785;
CC       Q92802; P25791: LMO2; NbExp=3; IntAct=EBI-2514973, EBI-739696;
CC       Q92802; Q9BRA0: NAA38; NbExp=3; IntAct=EBI-2514973, EBI-9106509;
CC       Q92802; O43447: PPIH; NbExp=10; IntAct=EBI-2514973, EBI-1055615;
CC       Q92802; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-2514973, EBI-2557649;
CC       Q92802; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-2514973, EBI-3957603;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q92802-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q92802-2; Sequence=VSP_027518;
CC       Name=3;
CC         IsoId=Q92802-3; Sequence=VSP_041337, VSP_041338, VSP_041339;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI31632.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
CC       Sequence=BP361938; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U50532; AAC50875.1; -; mRNA.
DR   EMBL; AF530063; AAQ09947.1; -; mRNA.
DR   EMBL; AL049783; CAB42441.1; -; mRNA.
DR   EMBL; BT007172; AAP35836.1; -; mRNA.
DR   EMBL; AL353665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471075; EAX08514.1; -; Genomic_DNA.
DR   EMBL; BC010643; AAH10643.1; -; mRNA.
DR   EMBL; BC131631; AAI31632.1; ALT_SEQ; mRNA.
DR   EMBL; BP361938; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS45024.1; -. [Q92802-3]
DR   CCDS; CCDS9346.1; -. [Q92802-1]
DR   RefSeq; NP_055702.1; NM_014887.2. [Q92802-1]
DR   RefSeq; XP_016875836.1; XM_017020347.1. [Q92802-1]
DR   RefSeq; XP_016875837.1; XM_017020348.1. [Q92802-1]
DR   RefSeq; XP_016875838.1; XM_017020349.1. [Q92802-1]
DR   AlphaFoldDB; Q92802; -.
DR   BioGRID; 115708; 81.
DR   IntAct; Q92802; 50.
DR   MINT; Q92802; -.
DR   STRING; 9606.ENSP00000382328; -.
DR   iPTMnet; Q92802; -.
DR   PhosphoSitePlus; Q92802; -.
DR   BioMuta; N4BP2L2; -.
DR   DMDM; 74751659; -.
DR   EPD; Q92802; -.
DR   jPOST; Q92802; -.
DR   MassIVE; Q92802; -.
DR   MaxQB; Q92802; -.
DR   PaxDb; Q92802; -.
DR   PeptideAtlas; Q92802; -.
DR   ProteomicsDB; 75485; -. [Q92802-1]
DR   ProteomicsDB; 75486; -. [Q92802-2]
DR   ProteomicsDB; 75487; -. [Q92802-3]
DR   Antibodypedia; 42083; 235 antibodies from 21 providers.
DR   DNASU; 10443; -.
DR   Ensembl; ENST00000267068.6; ENSP00000267068.3; ENSG00000244754.9. [Q92802-1]
DR   Ensembl; ENST00000399396.7; ENSP00000382328.3; ENSG00000244754.9. [Q92802-3]
DR   Ensembl; ENST00000446957.6; ENSP00000394239.2; ENSG00000244754.9. [Q92802-2]
DR   Ensembl; ENST00000674349.1; ENSP00000501516.1; ENSG00000244754.9. [Q92802-1]
DR   Ensembl; ENST00000674421.1; ENSP00000501518.1; ENSG00000244754.9. [Q92802-1]
DR   Ensembl; ENST00000674465.1; ENSP00000501416.1; ENSG00000244754.9. [Q92802-1]
DR   Ensembl; ENST00000674484.1; ENSP00000501537.1; ENSG00000244754.9. [Q92802-1]
DR   GeneID; 10443; -.
DR   KEGG; hsa:10443; -.
DR   MANE-Select; ENST00000267068.6; ENSP00000267068.3; NM_014887.3; NP_055702.1.
DR   UCSC; uc001uuk.5; human. [Q92802-1]
DR   AGR; HGNC:26916; -.
DR   CTD; 10443; -.
DR   DisGeNET; 10443; -.
DR   GeneCards; N4BP2L2; -.
DR   HGNC; HGNC:26916; N4BP2L2.
DR   HPA; ENSG00000244754; Low tissue specificity.
DR   MIM; 615788; gene.
DR   neXtProt; NX_Q92802; -.
DR   OpenTargets; ENSG00000244754; -.
DR   PharmGKB; PA162396632; -.
DR   VEuPathDB; HostDB:ENSG00000244754; -.
DR   eggNOG; KOG2401; Eukaryota.
DR   GeneTree; ENSGT00940000161440; -.
DR   HOGENOM; CLU_006655_0_0_1; -.
DR   InParanoid; Q92802; -.
DR   OMA; LNIGGQC; -.
DR   OrthoDB; 76267at2759; -.
DR   PhylomeDB; Q92802; -.
DR   TreeFam; TF336975; -.
DR   PathwayCommons; Q92802; -.
DR   SignaLink; Q92802; -.
DR   BioGRID-ORCS; 10443; 11 hits in 1075 CRISPR screens.
DR   ChiTaRS; N4BP2L2; human.
DR   GenomeRNAi; 10443; -.
DR   Pharos; Q92802; Tbio.
DR   PRO; PR:Q92802; -.
DR   Proteomes; UP000005640; Chromosome 13.
DR   RNAct; Q92802; protein.
DR   Bgee; ENSG00000244754; Expressed in calcaneal tendon and 199 other tissues.
DR   ExpressionAtlas; Q92802; baseline and differential.
DR   Genevisible; Q92802; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0017053; C:transcription repressor complex; IDA:UniProtKB.
DR   GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR   GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
DR   GO; GO:0001824; P:blastocyst development; IEA:Ensembl.
DR   GO; GO:1902037; P:negative regulation of hematopoietic stem cell differentiation; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:CAFA.
DR   GO; GO:1902035; P:positive regulation of hematopoietic stem cell proliferation; IMP:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR026568; NEDD4-bind_pro_2-like_2.
DR   InterPro; IPR026302; NEDD4_b_p2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13308:SF23; NEDD4-BINDING PROTEIN 2-LIKE 2; 1.
DR   PANTHER; PTHR13308; UNCHARACTERIZED; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..583
FT                   /note="NEDD4-binding protein 2-like 2"
FT                   /id="PRO_0000299026"
FT   REGION          549..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          162..197
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         8..32
FT                   /note="GKFLGPREEVTSEPRCKKLKSTTES -> EFCLVRIVMALCSALMTIFTIKM
FT                   GT (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041337"
FT   VAR_SEQ         33..461
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041338"
FT   VAR_SEQ         566..583
FT                   /note="RWGGSLGSHNRVCVTNNH -> RERVLKKTGHRLSKTKQKRNRKRNKKQNSQ
FT                   NRIMEENSLEFLSDLTPGDQDPSQSEEEDIEKTRRESEYPFIDGLQNEVGDFVTGYKEK
FT                   RWKNKDPKDSFQNVMSIVELDNTPKNYLSKEGDNLFVSLLLRPNEISVTCPILTQNLSC
FT                   VTTDDCSGMKVEKHIRNRHTIALDTQDLSAETSCLFMKKREIVDKNLSHEPILCHQHGI
FT                   RMSDKVLREEQVYTTKINHWAFFTTNLSDEDLQLGSDRQPYFGSWPAGPHKFICEQRPK
FT                   KDRACKLAGPDSRGQWIQMIFTSVAASEPGNNPEILTDKLLIGNEDFSPPPETMDSFIE
FT                   TNLFRSCLPQPDIPKNALESTKNKKRRKKRIFNLVPNFDLLGQSRIGVKEREKCDLLTK
FT                   NHGLKITLGEEKDRISERNSEEENKQKLMTFDHHPLWFYLDIIKATPLNIDGQRYSHCL
FT                   SFNRLRCSASLYKNYIPSFVLHNLSSIWKPSFTNKKLFLTFESQTRVGNKLNDAGFISP
FT                   EILHSHPDTSCSLGVTSDFHFLNERFDRKLKRWEEPKELPAEDSQDLTSTDYRSLELPL
FT                   SQGFAFQLVKLFGSPGVPMESLLPDDYVVPLDWKTLKMIYLQWKMSVEKRQKKIG (in
FT                   isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041339"
FT   VAR_SEQ         567..583
FT                   /note="WGGSLGSHNRVCVTNNH -> FDRKLKRWEEPKELPAEDSQDLTSTDYRSLE
FT                   LPLSQGFAFQLVKLFGSPGVPMESLLPDDYVVPLDWKTLKMIYLQWKMSVEKRQKKIG
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_027518"
FT   VARIANT         272
FT                   /note="Y -> H (in dbSNP:rs34062461)"
FT                   /id="VAR_034765"
SQ   SEQUENCE   583 AA;  67459 MW;  318DC4D81CD0FF2A CRC64;
     MSYGEIEGKF LGPREEVTSE PRCKKLKSTT ESYVFHNHSN ADFHRIQEKT GNDWVPVTII
     DVRGHSYLQE NKIKTTDLHR PLHDEMPGNR PDVIESIDSQ VLQEARPPLV SADDEIYSTS
     KAFIGPIYKP PEKKKRNEGR NEAHVLNGIN DRGGQKEKQK FNSEKSEIDN ELFQFYKEIE
     ELEKEKDGFE NSCKESEPSQ EQFVPFYEGH NNGLLKPDEE KKDLSNKAMP SHCDYQQNLG
     NEPDKYPCNG QVIPTFCDTS FTSFRPEWQS VYPFIVPYGP PLPSLNYHLN IQRFSGPPNP
     PSNIFQAQDD SQIQNGYYVN NCHVNWNCMT FDQNNEYTDC SENRSSVHPS GNGCSMQDRY
     VSNGFCEVRE RCWKDHCMDK HNGTDRFVNQ QFQEEKLNKL QKLLILLRGL PGSGKTTLSR
     ILLGQNRDGI VFSTDDYFHH QDGYRYNVNQ LGDAHDWNQN RAKQAIDQGR SPVIIDNTNI
     QAWEMKPYVE VAIGKGYRVE FHEPETWWKF DPEELEKRNK HGVSRKKIAQ MLDRYEYQMS
     ISIVMNSVEP SHKSTQRPPP PQGRQRWGGS LGSHNRVCVT NNH
//