ID TM9S4_HUMAN Reviewed; 642 AA. AC Q92544; B0QYT7; Q9NUA3; DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot. DT 26-FEB-2008, sequence version 2. DT 30-NOV-2010, entry version 83. DE RecName: Full=Transmembrane 9 superfamily member 4; DE Flags: Precursor; GN Name=TM9SF4; Synonyms=KIAA0255; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Bone marrow; RX MEDLINE=97191544; PubMed=9039502; DOI=10.1093/dnares/3.5.321; RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., RA Tanaka A., Kotani H., Miyajima N., Nomura N.; RT "Prediction of the coding sequences of unidentified human genes. VI. RT The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by RT analysis of cDNA clones from cell line KG-1 and brain."; RL DNA Res. 3:321-329(1996). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21638749; PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, and Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-312, AND MASS RP SPECTROMETRY. RC TISSUE=Platelet; RX PubMed=18088087; DOI=10.1021/pr0704130; RA Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., RA Schuetz C., Walter U., Gambaryan S., Sickmann A.; RT "Phosphoproteome of resting human platelets."; RL J. Proteome Res. 7:526-534(2008). CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein CC (Probable). CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) family. CC -!- SEQUENCE CAUTION: CC Sequence=AAH21107.1; Type=Erroneous initiation; CC Sequence=BAA13385.2; Type=Erroneous initiation; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D87444; BAA13385.2; ALT_INIT; mRNA. DR EMBL; AL049539; CAB75607.2; -; Genomic_DNA. DR EMBL; AL049539; CAQ09924.1; -; Genomic_DNA. DR EMBL; CH471077; EAW76391.1; -; Genomic_DNA. DR EMBL; BC021107; AAH21107.1; ALT_INIT; mRNA. DR EMBL; BC022850; AAH22850.2; -; mRNA. DR IPI; IPI00021985; -. DR RefSeq; NP_055557.2; NM_014742.3. DR UniGene; Hs.654665; -. DR ProteinModelPortal; Q92544; -. DR MINT; MINT-5006515; -. DR STRING; Q92544; -. DR PhosphoSite; Q92544; -. DR PeptideAtlas; Q92544; -. DR PRIDE; Q92544; -. DR Ensembl; ENST00000398022; ENSP00000381104; ENSG00000101337. DR GeneID; 9777; -. DR KEGG; hsa:9777; -. DR UCSC; uc002wxj.2; human. DR UCSC; uc002wxk.2; human. DR CTD; 9777; -. DR GeneCards; GC20P030697; -. DR H-InvDB; HIX0015722; -. DR HGNC; HGNC:30797; TM9SF4. DR PharmGKB; PA134937613; -. DR HOGENOM; HBG524073; -. DR HOVERGEN; HBG054197; -. DR InParanoid; Q92544; -. DR OMA; GSAPQEI; -. DR OrthoDB; EOG9BGCFW; -. DR NextBio; 36810; -. DR ArrayExpress; Q92544; -. DR Bgee; Q92544; -. DR CleanEx; HS_TM9SF4; -. DR Genevestigator; Q92544; -. DR GermOnline; ENSG00000101337; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR InterPro; IPR004240; EMP70. DR PANTHER; PTHR10766; EMP70; 1. DR Pfam; PF02990; EMP70; 1. PE 1: Evidence at protein level; KW Complete proteome; Membrane; Phosphoprotein; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 23 Potential. FT CHAIN 24 642 Transmembrane 9 superfamily member 4. FT /FTId=PRO_0000210178. FT TRANSMEM 282 302 Helical; (Potential). FT TRANSMEM 347 367 Helical; (Potential). FT TRANSMEM 377 397 Helical; (Potential). FT TRANSMEM 417 437 Helical; (Potential). FT TRANSMEM 450 470 Helical; (Potential). FT TRANSMEM 502 522 Helical; (Potential). FT TRANSMEM 536 556 Helical; (Potential). FT TRANSMEM 571 591 Helical; (Potential). FT TRANSMEM 599 619 Helical; (Potential). FT MOD_RES 312 312 Phosphotyrosine. SQ SEQUENCE 642 AA; 74519 MW; 91E8F925D64A5AE7 CRC64; MATAMDWLPW SLLLFSLMCE TSAFYVPGVA PINFHQNDPV EIKAVKLTSS RTQLPYEYYS LPFCQPSKIT YKAENLGEVL RGDRIVNTPF QVLMNSEKKC EVLCSQSNKP VTLTVEQSRL VAERITEDYY VHLIADNLPV ATRLELYSNR DSDDKKKEKD VQFEHGYRLG FTDVNKIYLH NHLSFILYYH REDMEEDQEH TYRVVRFEVI PQSIRLEDLK ADEKSSCTLP EGTNSSPQEI DPTKENQLYF TYSVHWEESD IKWASRWDTY LTMSDVQIHW FSIINSVVVV FFLSGILSMI IIRTLRKDIA NYNKEDDIED TMEESGWKLV HGDVFRPPQY PMILSSLLGS GIQLFCMILI VIFVAMLGML SPSSRGALMT TACFLFMFMG VFGGFSAGRL YRTLKGHRWK KGAFCTATLY PGVVFGICFV LNCFIWGKHS SGAVPFPTMV ALLCMWFGIS LPLVYLGYYF GFRKQPYDNP VRTNQIPRQI PEQRWYMNRF VGILMAGILP FGAMFIELFF IFSAIWENQF YYLFGFLFLV FIILVVSCSQ ISIVMVYFQL CAEDYRWWWR NFLVSGGSAF YVLVYAIFYF VNKLDIVEFI PSLLYFGYTA LMVLSFWLLT GTIGFYAAYM FVRKIYAAVK ID //