ID Q92317_YEAST PRELIMINARY; PRT; 146 AA. AC Q92317; O00064; P87340; DT 01-FEB-1997, integrated into UniProtKB/TrEMBL. DT 01-FEB-1997, sequence version 1. DT 30-MAY-2006, entry version 34. DE Transcriptional repressor Dr1p. GN Name=NCB2; Synonyms=DR1; OS Saccharomyces cerevisiae (Baker's yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4932; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97175685; PubMed=9023340; DOI=10.1073/pnas.94.3.820; RA Kim S., Na J.G., Hampsey M., Reinberg D.; RT "The Dr1/DRAP1 heterodimer is a global repressor of transcription in RT vivo."; RL Proc. Natl. Acad. Sci. U.S.A. 94:820-825(1997). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=97105886; PubMed=8948634; DOI=10.1093/nar/24.22.4450; RA Goppelt A.R., Meisterernst M.; RT "Characterization of the basal inhibitor of class II transcription NC2 RT from Saccharomyces cerevisiae."; RL Nucleic Acids Res. 24:4450-4455(1996). CC -!- FUNCTION: DNA polymerase II participates in chromosomal DNA CC replication (By similarity). CC -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = CC diphosphate + DNA(n+1). CC -!- SUBUNIT: Heterotetramer. Consists of four subunits: POL2, DPB2, CC DPB3 and DPB4 (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U91948; AAB51375.1; -; Genomic_DNA. DR EMBL; Y09266; CAA70461.1; -; mRNA. DR PIR; S69694; S69694. DR HSSP; Q01658; 1JFI. DR IntAct; Q92317; -. DR TRANSFAC; T03512; -. DR Ensembl; YDR397C; Saccharomyces cerevisiae. DR SGD; S000002805; NCB2. DR LinkHub; Q92317; -. DR GO; GO:0005634; C:nucleus; IPI. DR GO; GO:0003714; F:transcription corepressor activity; IGI. DR GO; GO:0000122; P:negative regulation of transcription from R...; IGI. DR InterPro; IPR003958; CBFA_NFYB_domain. DR InterPro; IPR007124; Hist_TAF. DR InterPro; IPR009072; Histone-fold. DR Pfam; PF00808; CBFD_NFYB_HMF; 1. KW DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; KW Transferase. SQ SEQUENCE 146 AA; 16650 MW; E04EB0D6F7E8D91D CRC64; MAGDSDNVSL PKATVQKMIS EILDQDLMFT KDAREIIINS GIEFIMILSS MASEMADNEA KKTIAPEHVI KALEELEYNE FIPFLEEILL NFKGSQKVKE TRDSKFKKSG LSEEELLRQQ EELFRQSRSR LHHNSVSDPV KSEDSS //