ID Q922Q7_MOUSE Unreviewed; 333 AA. AC Q922Q7; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 09-DEC-2015, entry version 80. DE SubName: Full=Cathepsin H {ECO:0000313|EMBL:AAH06878.1}; GN Name=Ctsh {ECO:0000313|EMBL:AAH06878.1, ECO:0000313|MGI:MGI:107285}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH06878.1}; RN [1] {ECO:0000313|EMBL:AAH06878.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N {ECO:0000313|EMBL:AAH06878.1}; RC TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old RC virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH06878.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Belongs to the peptidase C1 family. CC {ECO:0000256|RuleBase:RU362133}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC006878; AAH06878.1; -; mRNA. DR UniGene; Mm.2277; -. DR ProteinModelPortal; Q922Q7; -. DR STRING; 10090.ENSMUSP00000034915; -. DR PaxDb; Q922Q7; -. DR MGI; MGI:107285; Ctsh. DR eggNOG; COG4870; LUCA. DR eggNOG; KOG1543; Eukaryota. DR HOVERGEN; HBG011513; -. DR GO; GO:0097208; C:alveolar lamellar body; ISO:MGI. DR GO; GO:0005829; C:cytosol; ISO:MGI. DR GO; GO:0070062; C:extracellular exosome; ISO:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0005764; C:lysosome; ISO:MGI. DR GO; GO:0004177; F:aminopeptidase activity; ISO:MGI. DR GO; GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; ISO:MGI. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; ISO:MGI. DR GO; GO:0008234; F:cysteine-type peptidase activity; ISO:MGI. DR GO; GO:0004175; F:endopeptidase activity; ISO:MGI. DR GO; GO:0030108; F:HLA-A specific activating MHC class I receptor activity; ISO:MGI. DR GO; GO:0016505; F:peptidase activator activity involved in apoptotic process; IGI:MGI. DR GO; GO:0008233; F:peptidase activity; ISO:MGI. DR GO; GO:0070324; F:thyroid hormone binding; ISO:MGI. DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI. DR GO; GO:0010815; P:bradykinin catabolic process; ISO:MGI. DR GO; GO:0070371; P:ERK1 and ERK2 cascade; ISO:MGI. DR GO; GO:0002764; P:immune response-regulating signaling pathway; ISO:MGI. DR GO; GO:0033619; P:membrane protein proteolysis; ISO:MGI. DR GO; GO:0010813; P:neuropeptide catabolic process; ISO:MGI. DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IGI:MGI. DR GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI. DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI. DR GO; GO:0010952; P:positive regulation of peptidase activity; ISO:MGI. DR GO; GO:0031648; P:protein destabilization; ISO:MGI. DR GO; GO:0006508; P:proteolysis; ISO:MGI. DR GO; GO:0051603; P:proteolysis involved in cellular protein catabolic process; IBA:GO_Central. DR GO; GO:0043129; P:surfactant homeostasis; ISO:MGI. DR GO; GO:0031638; P:zymogen activation; ISO:MGI. DR InterPro; IPR025661; Pept_asp_AS. DR InterPro; IPR000169; Pept_cys_AS. DR InterPro; IPR025660; Pept_his_AS. DR InterPro; IPR013128; Peptidase_C1A. DR InterPro; IPR000668; Peptidase_C1A_C. DR InterPro; IPR013201; Prot_inhib_I29. DR PANTHER; PTHR12411; PTHR12411; 1. DR Pfam; PF08246; Inhibitor_I29; 1. DR Pfam; PF00112; Peptidase_C1; 1. DR PRINTS; PR00705; PAPAIN. DR SMART; SM00848; Inhibitor_I29; 1. DR SMART; SM00645; Pept_C1; 1. DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1. DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1. DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000256|SAAS:SAAS00007628}; KW Protease {ECO:0000256|SAAS:SAAS00007598}; KW Signal {ECO:0000256|RuleBase:RU362133}; KW Thiol protease {ECO:0000256|SAAS:SAAS00007616}. FT SIGNAL 1 21 {ECO:0000256|RuleBase:RU362133}. FT CHAIN 22 333 {ECO:0000256|RuleBase:RU362133}. FT /FTId=PRO_5005401221. FT DOMAIN 33 88 Inhibitor_I29. {ECO:0000259|SMART: FT SM00848}. FT DOMAIN 114 330 Pept_C1. {ECO:0000259|SMART:SM00645}. SQ SEQUENCE 333 AA; 37155 MW; C28B344AC3439DE8 CRC64; MWAALPLLCA GAWLLSTGAT AELTVNAIEK FHFKSWMKQH QKTYSSVEYN HRLQMFANNW RKIQAHNQRN HTFKMALNQF SDMSFAEIKH KFLWSEPQNC SATKSNYLRG TGPYPSSMDW RKKGNVVSPV INQGACGSCW TFSTTGALES AVAIASGKML SLAEQQLVDC AQAFNNHGCK GGLPSQAFEY ILYNKGIMEE DSYPYIGKDS SCRFNPQKAV AFVKNVVNIT LNDEAAMVEA VALYNPVSFA FEVTEDFLMY KSGVYSSKSC HKTPDKVNHA VLAVGYGEQN GLLYWIVKNS WGSQWGENGY FLIERGKNMC GLAACASYPI PQV //