ID CTSR1_MOUSE Reviewed; 686 AA. AC Q91ZR5; Q4PZC3; Q4PZC4; Q4PZC5; Q4PZC6; Q4PZD2; DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 16-APR-2014, entry version 87. DE RecName: Full=Cation channel sperm-associated protein 1; DE Short=CatSper1; GN Name=Catsper1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE. RX PubMed=11595941; DOI=10.1038/35098027; RA Ren D., Navarro B., Perez G., Jackson A.C., Hsu S., Shi Q., RA Tilly J.L., Clapham D.E.; RT "A sperm ion channel required for sperm motility and male fertility."; RL Nature 413:603-609(2001). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-307, AND VARIANTS HIS-PRO-25 RP INS; ARG-52; GLN-160 DEL; ILE-270 AND SER-276. RC STRAIN=2, 35, 41, 47, 49, 51, 58, 61, 63, and 72; RX PubMed=15930155; DOI=10.1093/molbev/msi178; RA Podlaha O., Webb D.M., Tucker P.K., Zhang J.; RT "Positive selection for indel substitutions in the rodent sperm RT protein catsper1."; RL Mol. Biol. Evol. 22:1845-1852(2005). RN [3] RP FUNCTION. RX PubMed=14657352; DOI=10.1073/pnas.2536658100; RA Carlson A.E., Westenbroek R.E., Quill T., Ren D., Clapham D.E., RA Hille B., Garbers D.L., Babcock D.F.; RT "CatSper1 required for evoked Ca2+ entry and control of flagellar RT function in sperm."; RL Proc. Natl. Acad. Sci. U.S.A. 100:14864-14868(2003). RN [4] RP DEVELOPMENTAL STAGE. RX PubMed=14688170; DOI=10.1093/humrep/deh043; RA Nikpoor P., Mowla S.J., Movahedin M., Ziaee S.A.-M., Tiraihi T.; RT "CatSper gene expression in postnatal development of mouse testis and RT in subfertile men with deficient sperm motility."; RL Hum. Reprod. 19:124-128(2004). RN [5] RP FUNCTION. RX PubMed=16036917; DOI=10.1074/jbc.M501430200; RA Carlson A.E., Quill T.A., Westenbroek R.E., Schuh S.M., Hille B., RA Babcock D.F.; RT "Identical phenotypes of CatSper1 and CatSper2 null sperm."; RL J. Biol. Chem. 280:32238-32244(2005). RN [6] RP FUNCTION. RX PubMed=16467839; DOI=10.1038/nature04417; RA Kirichok Y., Navarro B., Clapham D.E.; RT "Whole-cell patch-clamp measurements of spermatozoa reveal an RT alkaline-activated Ca2+ channel."; RL Nature 439:737-740(2006). RN [7] RP FUNCTION. RX PubMed=17174296; DOI=10.1016/j.ydbio.2006.11.007; RA Marquez B., Ignotz G., Suarez S.S.; RT "Contributions of extracellular and intracellular Ca2+ to regulation RT of sperm motility: release of intracellular stores can hyperactivate RT CatSper1 and CatSper2 null sperm."; RL Dev. Biol. 303:214-221(2007). RN [8] RP IDENTIFICATION IN A COMPLEX WITH CATSPERB AND HSPA1B. RX PubMed=17478420; DOI=10.1074/jbc.M701083200; RA Liu J., Xia J., Cho K.-H., Clapham D.E., Ren D.; RT "CatSperbeta, a novel transmembrane protein in the CatSper channel RT complex."; RL J. Biol. Chem. 282:18945-18952(2007). RN [9] RP DEVELOPMENTAL STAGE. RX PubMed=17347248; DOI=10.1093/molehr/gam009; RA Li H.-G., Ding X.-F., Liao A.-H., Kong X.-B., Xiong C.-L.; RT "Expression of CatSper family transcripts in the mouse testis during RT post-natal development and human ejaculated spermatozoa: relationship RT to sperm motility."; RL Mol. Hum. Reprod. 13:299-306(2007). RN [10] RP INTERACTION WITH CATSPER3 AND CATSPER4. RX PubMed=17227845; DOI=10.1073/pnas.0610286104; RA Qi H., Moran M.M., Navarro B., Chong J.A., Krapivinsky G., RA Krapivinsky L., Kirichok Y., Ramsey I.S., Quill T.A., Clapham D.E.; RT "All four CatSper ion channel proteins are required for male fertility RT and sperm cell hyperactivated motility."; RL Proc. Natl. Acad. Sci. U.S.A. 104:1219-1223(2007). RN [11] RP IDENTIFICATION IN A COMPLEX WITH CATSPERB; CATSPERG2 AND HSPA1B. RX PubMed=19516020; DOI=10.1095/biolreprod.109.077107; RA Wang H., Liu J., Cho K.-H., Ren D.; RT "A novel, single, transmembrane protein CATSPERG is associated with RT CATSPER1 channel protein."; RL Biol. Reprod. 81:539-544(2009). RN [12] RP LACK OF ACTIVATION BY PROGESTERONE AND PGE1. RX PubMed=21412339; DOI=10.1038/nature09767; RA Lishko P.V., Botchkina I.L., Kirichok Y.; RT "Progesterone activates the principal Ca2+ channel of human sperm."; RL Nature 471:387-391(2011). RN [13] RP IDENTIFICATION IN THE CATSPER COMPLEX. RC STRAIN=C57BL/6; RX PubMed=21224844; DOI=10.1038/ncomms1153; RA Chung J.J., Navarro B., Krapivinsky G., Krapivinsky L., Clapham D.E.; RT "A novel gene required for male fertility and functional CATSPER RT channel formation in spermatozoa."; RL Nat. Commun. 2:153-153(2011). CC -!- FUNCTION: Voltage-gated calcium channel that plays a central role CC in sperm cell hyperactivation. Controls calcium entry to mediate CC the hyperactivated motility, a step needed for sperm motility CC which is essential late in the preparation of sperm for CC fertilization. Activated by intracellular alkalinization. Contrary CC to the human ortholog, not activated by progesterone. CC -!- SUBUNIT: Heterotetramer; possibly composed of CATSPER1, CATSPER2, CC CATSPER3 and CATSPER4 (Potential). Interacts with CC Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel CC activity (By similarity). Component of the CatSper complex. CC Interacts with CATSPER3 and CATSPER4. CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane; CC Multi-pass membrane protein. Note=Specifically located in the CC principal piece of sperm tail. CC -!- TISSUE SPECIFICITY: Testis-specific. CC -!- DEVELOPMENTAL STAGE: Detected only after round spermatids are CC produced at approximatly day 18. CC -!- DISRUPTION PHENOTYPE: Mice are normal but males are sterile. Male CC sterility is due to defects in sperm motility unability to CC fertilize intact eggs. In mice lacking Catsper1, sperm lacks CC CatSper2 protein, while in mice lacking CatSper1, sperm lacks CC CatSper1 protein, suggesting that stable expression of CatSper1 CC protein requires CatSper2 and vice versa. CC -!- SIMILARITY: Belongs to the cation channel sperm-associated CC (TC 1.A.1.19) family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF407332; AAL14104.1; -; mRNA. DR EMBL; DQ021482; AAY63820.1; -; Genomic_DNA. DR EMBL; DQ021483; AAY63821.1; -; Genomic_DNA. DR EMBL; DQ021484; AAY63822.1; -; Genomic_DNA. DR EMBL; DQ021485; AAY63823.1; -; Genomic_DNA. DR EMBL; DQ021486; AAY63824.1; -; Genomic_DNA. DR EMBL; DQ021488; AAY63826.1; -; Genomic_DNA. DR EMBL; DQ021489; AAY63827.1; -; Genomic_DNA. DR EMBL; DQ021490; AAY63828.1; -; Genomic_DNA. DR EMBL; DQ021491; AAY63829.1; -; Genomic_DNA. DR EMBL; DQ021492; AAY63830.1; -; Genomic_DNA. DR RefSeq; NP_647462.1; NM_139301.2. DR UniGene; Mm.87321; -. DR ProteinModelPortal; Q91ZR5; -. DR SMR; Q91ZR5; 346-578. DR BioGrid; 230434; 6. DR STRING; 10090.ENSMUSP00000045430; -. DR GuidetoPHARMACOLOGY; 388; -. DR TCDB; 1.A.1.19.3; the voltage-gated ion channel (vic) superfamily. DR PhosphoSite; Q91ZR5; -. DR PRIDE; Q91ZR5; -. DR DNASU; 225865; -. DR Ensembl; ENSMUST00000043380; ENSMUSP00000045430; ENSMUSG00000038498. DR GeneID; 225865; -. DR KEGG; mmu:225865; -. DR UCSC; uc008gcp.1; mouse. DR CTD; 117144; -. DR MGI; MGI:2179947; Catsper1. DR eggNOG; NOG270165; -. DR GeneTree; ENSGT00720000108882; -. DR HOGENOM; HOG000112051; -. DR InParanoid; Q91ZR5; -. DR KO; K16889; -. DR OrthoDB; EOG7FV3Q9; -. DR PhylomeDB; Q91ZR5; -. DR TreeFam; TF329330; -. DR NextBio; 377825; -. DR PRO; PR:Q91ZR5; -. DR Bgee; Q91ZR5; -. DR CleanEx; MM_CATSPER1; -. DR Genevestigator; Q91ZR5; -. DR GO; GO:0036128; C:CatSper complex; IDA:UniProtKB. DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro. DR GO; GO:0005245; F:voltage-gated calcium channel activity; IMP:MGI. DR GO; GO:0006816; P:calcium ion transport; IMP:MGI. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0001539; P:ciliary or bacterial-type flagellar motility; IMP:MGI. DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane; IMP:MGI. DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. DR GO; GO:0051924; P:regulation of calcium ion transport; IMP:MGI. DR GO; GO:0030317; P:sperm motility; IMP:MGI. DR GO; GO:0007283; P:spermatogenesis; IMP:MGI. DR Gene3D; 1.20.120.350; -; 1. DR InterPro; IPR028746; CatSper1. DR InterPro; IPR027359; Channel_four-helix_dom. DR InterPro; IPR005821; Ion_trans_dom. DR PANTHER; PTHR10037:SF32; PTHR10037:SF32; 1. DR Pfam; PF00520; Ion_trans; 1. PE 1: Evidence at protein level; KW Calcium; Calcium channel; Calcium transport; Cell membrane; KW Cell projection; Cilium; Complete proteome; Developmental protein; KW Differentiation; Flagellum; Ion channel; Ion transport; Membrane; KW Reference proteome; Spermatogenesis; Transmembrane; KW Transmembrane helix; Transport; Voltage-gated channel. FT CHAIN 1 686 Cation channel sperm-associated protein FT 1. FT /FTId=PRO_0000295675. FT TOPO_DOM 1 349 Cytoplasmic (Potential). FT TRANSMEM 350 370 Helical; Name=Segment S1; (Potential). FT TOPO_DOM 371 383 Extracellular (Potential). FT TRANSMEM 384 404 Helical; Name=Segment S2; (Potential). FT TOPO_DOM 405 417 Cytoplasmic (Potential). FT TRANSMEM 418 438 Helical; Name=Segment S3; (Potential). FT TOPO_DOM 439 447 Extracellular (Potential). FT TRANSMEM 448 468 Helical; Name=Segment S4; (Potential). FT TOPO_DOM 469 485 Cytoplasmic (Potential). FT TRANSMEM 486 506 Helical; Name=Segment S5; (Potential). FT TOPO_DOM 507 521 Extracellular (Potential). FT INTRAMEM 522 542 Helical; Pore-forming; (Potential). FT TOPO_DOM 543 552 Extracellular (Potential). FT TRANSMEM 553 573 Helical; Name=Segment S6; (Potential). FT TOPO_DOM 574 686 Cytoplasmic (Potential). FT COMPBIAS 12 255 His-rich. FT VARIANT 25 25 S -> SHP (in strain: 72). FT VARIANT 52 52 M -> R (in strain: 2, 47 and 58). FT VARIANT 160 160 Missing (in strain: 47). FT VARIANT 270 270 T -> I (in strain: 72). FT VARIANT 276 276 Y -> S (in strain: 72). SQ SEQUENCE 686 AA; 78706 MW; 2E85FFE72B3147BC CRC64; MDQSSRRDES YHETHPGSLD PSHQSHPHPH PHPTLHRPNQ GGVYYDSPQH GMFQQPYQQH GGFHQQNELQ HLREFSDSHD NAFSHHSYQQ DRAGVSTLPN NISHAYGGSH PLAESQHSGG PQSGPRIDPN HHPHQDDPHR PSEPLSHPSS TGSHQGTTHQ QYHERSHHLN PQQNRDHADT ISYRSSTRFY RSHAPFSRQE RPHLHADHHH EGHHAHSHHG EHPHHKEQRH YHGDHMHHHI HHRSPSASQL SHKSHSTLAT SPSHVGSKST ASGARYTFGA RSQIFGKAQS RESLRESASL SEGEDHVQKR KKAQRAHKKA HTGNIFQLLW EKISHLLLGL QQMILSLTQS LGFETFIFIV VCLNTVILVA QTFTELEIRG EWYFMVLDSI FLSIYVLEAV LKLIALGLEY FYDPWNNLDF FIMVMAVLDF VLLQINSLSY SFYNHSLFRI LKVFKSMRAL RAIRVLRRLS ILTSLHEVAG TLSGSLPSIT AILTLMFTCL FLFSVVLRAL FQDSDPKRFQ NIFTTLFTLF TMLTLDDWSL IYIDNRAQGA WYIIPILMIY IVIQYFIFLN LVIAVLVDNF QMALLKGLEK VKLEQAARVH EKLLDDSLTD LNKADANAQM TEEALKMQLI EGMFGNMTVK QRVLHFQFLQ LVAAVEQHQQ KFRSQAYVID ELVDMAFEAG DDDYGK //