ID B4GT3_MOUSE Reviewed; 395 AA. AC Q91YY2; Q9QY13; DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 16-NOV-2011, entry version 80. DE RecName: Full=Beta-1,4-galactosyltransferase 3; DE Short=Beta-1,4-GalTase 3; DE Short=Beta4Gal-T3; DE Short=b4Gal-T3; DE EC=2.4.1.-; DE AltName: Full=UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; DE AltName: Full=UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; DE Includes: DE RecName: Full=N-acetyllactosamine synthase; DE EC=2.4.1.90; DE AltName: Full=Nal synthase; DE Includes: DE RecName: Full=Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase; DE EC=2.4.1.38; DE Includes: DE RecName: Full=Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase; DE EC=2.4.1.-; GN Name=B4galt3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98259838; PubMed=9597550; DOI=10.1093/glycob/8.5.517; RA Lo N.-W., Shaper J.H., Pevsner J., Shaper N.L.; RT "The expanding beta 4-galactosyltransferase gene family: messages from RT the databanks."; RL Glycobiology 8:517-526(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-339, AND MASS RP SPECTROMETRY. RX PubMed=19349973; DOI=10.1038/nbt.1532; RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., RA Schiess R., Aebersold R., Watts J.D.; RT "Mass-spectrometric identification and relative quantification of N- RT linked cell surface glycoproteins."; RL Nat. Biotechnol. 27:378-386(2009). CC -!- FUNCTION: Responsible for the synthesis of complex-type N-linked CC oligosaccharides in many glycoproteins as well as the carbohydrate CC moieties of glycolipids (By similarity). CC -!- CATALYTIC ACTIVITY: UDP-galactose + N-acetyl-beta-D- CC glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N- CC acetyl-beta-D-glucosaminylglycopeptide. CC -!- CATALYTIC ACTIVITY: UDP-galactose + N-acetyl-D-glucosamine = UDP + CC N-acetyllactosamine. CC -!- COFACTOR: Manganese (By similarity). CC -!- PATHWAY: Protein modification; protein glycosylation. CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; CC Single-pass type II membrane protein (By similarity). Note=Trans CC cisternae of Golgi stack (By similarity). CC -!- SIMILARITY: Belongs to the glycosyltransferase 7 family. CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; CC Note=b4GalT3; CC URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_462"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF142671; AAF22221.1; -; mRNA. DR EMBL; BC013619; AAH13619.1; -; mRNA. DR IPI; IPI00314900; -. DR RefSeq; NP_065604.2; NM_020579.2. DR UniGene; Mm.274011; -. DR ProteinModelPortal; Q91YY2; -. DR SMR; Q91YY2; 75-348. DR STRING; Q91YY2; -. DR CAZy; GT7; Glycosyltransferase Family 7. DR PhosphoSite; Q91YY2; -. DR PRIDE; Q91YY2; -. DR Ensembl; ENSMUST00000064272; ENSMUSP00000066353; ENSMUSG00000052423. DR Ensembl; ENSMUST00000111313; ENSMUSP00000106945; ENSMUSG00000052423. DR GeneID; 57370; -. DR KEGG; mmu:57370; -. DR CTD; 8703; -. DR MGI; MGI:1928767; B4galt3. DR GeneTree; ENSGT00550000074204; -. DR HOGENOM; HBG717407; -. DR HOVERGEN; HBG058334; -. DR InParanoid; Q91YY2; -. DR OMA; DYSHPHD; -. DR OrthoDB; EOG476K13; -. DR PhylomeDB; Q91YY2; -. DR NextBio; 313744; -. DR ArrayExpress; Q91YY2; -. DR Bgee; Q91YY2; -. DR Genevestigator; Q91YY2; -. DR GermOnline; ENSMUSG00000052423; Mus musculus. DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0003831; F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; IEA:EC. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003945; F:N-acetyllactosamine synthase activity; IEA:EC. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR InterPro; IPR003859; Galactosyl_T_2_met. DR KO; K07968; -. DR PANTHER; PTHR19300; Galactosyl_T_2; 1. DR Pfam; PF02709; Galactosyl_T_2; 1. DR PRINTS; PR02050; B14GALTRFASE. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; KW Golgi apparatus; Manganese; Membrane; Metal-binding; KW Reference proteome; Signal-anchor; Transferase; Transmembrane; KW Transmembrane helix. FT CHAIN 1 395 Beta-1,4-galactosyltransferase 3. FT /FTId=PRO_0000080538. FT TOPO_DOM 1 10 Cytoplasmic (Potential). FT TRANSMEM 11 31 Helical; Signal-anchor for type II FT membrane protein; (Potential). FT TOPO_DOM 32 395 Lumenal (Potential). FT METAL 199 199 Manganese (By similarity). FT METAL 293 293 Manganese (By similarity). FT CARBOHYD 57 57 N-linked (GlcNAc...) (Potential). FT CARBOHYD 168 168 N-linked (GlcNAc...) (Potential). FT CARBOHYD 339 339 N-linked (GlcNAc...). FT CARBOHYD 387 387 N-linked (GlcNAc...) (Potential). FT DISULFID 79 121 By similarity. FT DISULFID 192 211 By similarity. FT CONFLICT 353 353 S -> A (in Ref. 1; AAF22221). SQ SEQUENCE 395 AA; 44084 MW; 16401B033EEB4B21 CRC64; MLRRLLERPC TLALLVGSQL AVMMYLSLGG FRSLSALFGR DPGPTFDYSH PHDVYSNLSH LPAAPGAAGA PPAQALPYCP ERSPFLVGPV SVSFSPVPSL AEIVERNPRV ESGGRYRPAG CEPRSRTAII VPHRAREHHL RLLLYHLHPF LQRQQLAYGI YVIHQAGNGT FNRAKLLNVG VREALRDEEW DCLFLHDVDL LPENDHNLYV CDPRGPRHVA VAMNKFGYSL PYPQYFGGVS ALTPDQYLKM NGFPNEYWGW GGEDDDIATR VRLAGMKISR PPTSVGHYKM VKHRGDKGNE ENPHRFDLLV RTQNSWTQDG MNSLTYRLLA RELGPLYTNI TADIGTDPRG PRSPSGPRYP PGSSQAFRQE MLQRRPPARP GPLPTANHTA PRGSH //