ID Q91YH6_MOUSE Unreviewed; 513 AA. AC Q91YH6; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 30-NOV-2010, entry version 84. DE SubName: Full=ATPase, H+ transporting, lysosomal V1 subunit B1; DE SubName: Full=ATPase, H+ transporting, lysosomal V1 subunit B1, isoform CRA_a; DE SubName: Full=Putative uncharacterized protein; DE SubName: Full=Vacuolar proton translocating ATPase B1 isoform; GN Name=Atp6v1b1; ORFNames=mCG_142376; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; RC TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old RC virgin mouse. Taken by biopsy.; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RX MEDLINE=22036378; PubMed=12040188; DOI=10.1126/science.1069193; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., RA Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., RA Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W., RA Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., RA Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., RA Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., RA Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., RA Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., RA Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., RA Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., RA Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., RA Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., RA Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., RA Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., RA Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., RA Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., RA Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., RA Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., RA Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., RA Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., RA Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., RA Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., RA Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., RA Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., RA Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., RA Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., RA Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., RA Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., RA Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., RA Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., RA Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., RA Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.; RT "A comparison of whole-genome shotgun-derived mouse chromosome 16 and RT the human genome."; RL Science 296:1661-1671(2002). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Mixed; RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RX MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RG The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RX MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney, and Lung; RX MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Lung; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [13] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Kidney; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL; TISSUE=Kidney; RA Nishi T., Forgac M.; RT "Interaction of the a and B subunit isoforms of the mouse vacuolar RT proton translocating ATPase."; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC017127; AAH17127.1; -; mRNA. DR EMBL; AF435091; AAN45856.1; -; mRNA. DR EMBL; AK052604; BAC35059.1; -; mRNA. DR EMBL; AK052707; BAC35108.1; -; mRNA. DR EMBL; AK078810; BAC37404.1; -; mRNA. DR EMBL; AK168980; BAE40781.1; -; mRNA. DR EMBL; CH466523; EDK99099.1; -; Genomic_DNA. DR IPI; IPI00458922; -. DR RefSeq; NP_598918.1; NM_134157.2. DR UniGene; Mm.220823; -. DR ProteinModelPortal; Q91YH6; -. DR SMR; Q91YH6; 49-500. DR STRING; Q91YH6; -. DR Ensembl; ENSMUST00000006431; ENSMUSP00000006431; ENSMUSG00000006269. DR GeneID; 110935; -. DR KEGG; mmu:110935; -. DR UCSC; uc009coc.1; mouse. DR CTD; 110935; -. DR MGI; MGI:103285; Atp6v1b1. DR HOVERGEN; HBG002176; -. DR InParanoid; Q91YH6; -. DR OMA; RTRKDHG; -. DR OrthoDB; EOG980MG9; -. DR PhylomeDB; Q91YH6; -. DR NextBio; 364973; -. DR ArrayExpress; Q91YH6; -. DR Bgee; Q91YH6; -. DR Genevestigator; Q91YH6; -. DR GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB. DR GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI. DR GO; GO:0005624; C:membrane fraction; IDA:MGI. DR GO; GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:HAMAP. DR GO; GO:0046933; F:hydrogen ion transporting ATP synthase acti...; IEA:HAMAP. DR GO; GO:0046961; F:proton-transporting ATPase activity, rotati...; IEA:InterPro. DR GO; GO:0042777; P:plasma membrane ATP synthesis coupled proto...; IEA:HAMAP. DR GO; GO:0006885; P:regulation of pH; IMP:MGI. DR HAMAP; MF_00310; ATP_synth_B_arch; 1; -. DR InterPro; IPR020003; ATPase_a/bsu_AS. DR InterPro; IPR000194; ATPase_a/bsu_nucl-bd. DR InterPro; IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C. DR InterPro; IPR004100; ATPase_F1/V1/A1-cplx_a/bsu_N. DR InterPro; IPR005723; ATPase_V1-cplx_bsu. DR InterPro; IPR022879; V-ATPase_su_B/beta. DR Pfam; PF00006; ATP-synt_ab; 1. DR Pfam; PF00306; ATP-synt_ab_C; 1. DR Pfam; PF02874; ATP-synt_ab_N; 1. DR TIGRFAMs; TIGR01040; V-ATPase_V1_B; 1. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1. PE 2: Evidence at transcript level; KW Hydrogen ion transport; Ion transport; Transport. SQ SEQUENCE 513 AA; 56791 MW; 43EE1D236D4F6406 CRC64; MATTVDSRSS GFTGNSCDPG TAQEHVQAVT RNYITHPRVT YRTVCSVNGP LVVLDQVKFA QYAEIVNFTL PDGTQRSGQV LEVAGTKAIV QVFEGTSGID SQKTTCEFTG DILRTPVSED MLGRIFNGSG KPIDKGPAVM AEEFLDINGQ PINPHDRIYP EEMIQTGISP IDVMNSIARG QKIPIFSAAG LPHNEIAAQI CRQAGLVKKS KAVLDYHEDN FAIVFAAMGV NMETARFFKS DFEQNGTMGN VCLFLNLAND PTIERIITPR LALTTAEFLA YQCEKHVLVI LTDMSSYAEA LREVSAAREE VPGRRGFPGY MYTDLATIYE RAGRVEGRGG SITQIPILTM PNDDITHPIP DLTGFITEGQ IYVDRQLHNR QVYPPINVLP SLSRLMKSAI GEGMTRKDHG DVSNQLYACY AIGKDVQAMK AVVGEEALTS EDLLYLEFLQ KFEKNFITQG PYENRTVFES LDLGWKLLRI FPKEMLKRIP QSMTDEFYSR QGAQQDPASD TAL //