ID Q91YH6_MOUSE Unreviewed; 513 AA. AC Q91YH6; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 02-DEC-2020, entry version 173. DE RecName: Full=Vacuolar proton pump subunit B {ECO:0000256|RuleBase:RU366021}; DE Short=V-ATPase subunit B {ECO:0000256|RuleBase:RU366021}; DE AltName: Full=Vacuolar proton pump subunit B {ECO:0000256|RuleBase:RU366021}; GN Name=Atp6v1b1 {ECO:0000313|EMBL:AAH17127.1, GN ECO:0000313|Ensembl:ENSMUSP00000006431, ECO:0000313|MGI:MGI:103285}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH17127.1}; RN [1] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AAN45856.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL {ECO:0000313|EMBL:AAN45856.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:AAN45856.1}; RA Nishi T., Forgac M.; RT "Interaction of the a and B subunit isoforms of the mouse vacuolar proton RT translocating ATPase."; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [8] {ECO:0000313|EMBL:AAH17127.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N {ECO:0000313|EMBL:AAH17127.1}; RC TISSUE=Mammary tumor. Metallothionien-TGF alpha model. 10 month old RC virgin mouse. Taken by biopsy. {ECO:0000313|EMBL:AAH17127.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] {ECO:0000313|EMBL:BAE40781.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE40781.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAE40781.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [11] {ECO:0000313|EMBL:BAC35059.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC35059.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC35059.1}, and Lung RC {ECO:0000313|EMBL:BAC37404.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [12] {ECO:0000313|Ensembl:ENSMUSP00000006431, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000006431, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [13] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [14] {ECO:0000313|Ensembl:ENSMUSP00000006431} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000006431}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Non-catalytic subunit of the peripheral V1 complex of CC vacuolar ATPase. {ECO:0000256|RuleBase:RU366021}. CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral CC catalytic V1 complex attached to an integral membrane V0 proton pore CC complex. {ECO:0000256|RuleBase:RU366021}. CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family. CC {ECO:0000256|ARBA:ARBA00008936, ECO:0000256|RuleBase:RU366021}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC090647; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC017127; AAH17127.1; -; mRNA. DR EMBL; AF435091; AAN45856.1; -; mRNA. DR EMBL; AK052604; BAC35059.1; -; mRNA. DR EMBL; AK052707; BAC35108.1; -; mRNA. DR EMBL; AK078810; BAC37404.1; -; mRNA. DR EMBL; AK168980; BAE40781.1; -; mRNA. DR RefSeq; NP_598918.1; NM_134157.2. DR IntAct; Q91YH6; 3. DR STRING; 10090.ENSMUSP00000006431; -. DR TCDB; 3.A.2.2.6; the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily. DR Antibodypedia; 4020; 355 antibodies. DR DNASU; 110935; -. DR Ensembl; ENSMUST00000006431; ENSMUSP00000006431; ENSMUSG00000006269. DR GeneID; 110935; -. DR KEGG; mmu:110935; -. DR UCSC; uc009coc.1; mouse. DR CTD; 525; -. DR MGI; MGI:103285; Atp6v1b1. DR eggNOG; KOG1351; Eukaryota. DR GeneTree; ENSGT00940000161413; -. DR HOGENOM; CLU_022916_0_0_1; -. DR OMA; AVLDYHE; -. DR OrthoDB; 541116at2759; -. DR TreeFam; TF300313; -. DR Reactome; R-MMU-1222556; ROS and RNS production in phagocytes. DR Reactome; R-MMU-77387; Insulin receptor recycling. DR Reactome; R-MMU-917977; Transferrin endocytosis and recycling. DR Reactome; R-MMU-9639288; Amino acids regulate mTORC1. DR Reactome; R-MMU-983712; Ion channel transport. DR BioGRID-ORCS; 110935; 1 hit in 17 CRISPR screens. DR ChiTaRS; Atp6v1b1; mouse. DR Proteomes; UP000000589; Chromosome 6. DR Bgee; ENSMUSG00000006269; Expressed in cortex of kidney and 158 other tissues. DR GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB. DR GO; GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005829; C:cytosol; IDA:UniProtKB. DR GO; GO:0098850; C:extrinsic component of synaptic vesicle membrane; ISO:MGI. DR GO; GO:0016328; C:lateral plasma membrane; IDA:UniProtKB. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0005902; C:microvillus; IDA:UniProtKB. DR GO; GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro. DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI. DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; ISS:UniProtKB. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI. DR GO; GO:0015078; F:proton transmembrane transporter activity; IMP:UniProtKB. DR GO; GO:0030534; P:adult behavior; IMP:MGI. DR GO; GO:0046034; P:ATP metabolic process; IMP:MGI. DR GO; GO:0055074; P:calcium ion homeostasis; ISS:UniProtKB. DR GO; GO:0055064; P:chloride ion homeostasis; IMP:MGI. DR GO; GO:0007588; P:excretion; ISS:UniProtKB. DR GO; GO:0042048; P:olfactory behavior; IMP:MGI. DR GO; GO:0001503; P:ossification; ISS:UniProtKB. DR GO; GO:0045851; P:pH reduction; ISS:UniProtKB. DR GO; GO:0055075; P:potassium ion homeostasis; IMP:MGI. DR GO; GO:0006693; P:prostaglandin metabolic process; IMP:MGI. DR GO; GO:1902600; P:proton transmembrane transport; IMP:UniProtKB. DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI. DR GO; GO:0006885; P:regulation of pH; IMP:UniProtKB. DR GO; GO:0035812; P:renal sodium excretion; IMP:MGI. DR GO; GO:0003096; P:renal sodium ion transport; IMP:MGI. DR GO; GO:0003091; P:renal water homeostasis; IMP:MGI. DR GO; GO:0007605; P:sensory perception of sound; ISO:MGI. DR HAMAP; MF_00310; ATP_synth_B_arch; 1. DR InterPro; IPR020003; ATPase_a/bsu_AS. DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N. DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd. DR InterPro; IPR005723; ATPase_V1-cplx_bsu. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR022879; V-ATPase_su_B/beta. DR PANTHER; PTHR43389; PTHR43389; 1. DR Pfam; PF00006; ATP-synt_ab; 1. DR Pfam; PF02874; ATP-synt_ab_N; 1. DR PIRSF; PIRSF039114; V-ATPsynth_beta/V-ATPase_B; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR01040; V-ATPase_V1_B; 1. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1. PE 1: Evidence at protein level; KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781, KW ECO:0000256|RuleBase:RU366021}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU366021}; KW Proteomics identification {ECO:0000213|MaxQB:Q91YH6}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366021}. FT DOMAIN 44..110 FT /note="ATP-synt_ab_N" FT /evidence="ECO:0000259|Pfam:PF02874" FT DOMAIN 167..393 FT /note="ATP-synt_ab" FT /evidence="ECO:0000259|Pfam:PF00006" FT REGION 1..21 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 513 AA; 56791 MW; 43EE1D236D4F6406 CRC64; MATTVDSRSS GFTGNSCDPG TAQEHVQAVT RNYITHPRVT YRTVCSVNGP LVVLDQVKFA QYAEIVNFTL PDGTQRSGQV LEVAGTKAIV QVFEGTSGID SQKTTCEFTG DILRTPVSED MLGRIFNGSG KPIDKGPAVM AEEFLDINGQ PINPHDRIYP EEMIQTGISP IDVMNSIARG QKIPIFSAAG LPHNEIAAQI CRQAGLVKKS KAVLDYHEDN FAIVFAAMGV NMETARFFKS DFEQNGTMGN VCLFLNLAND PTIERIITPR LALTTAEFLA YQCEKHVLVI LTDMSSYAEA LREVSAAREE VPGRRGFPGY MYTDLATIYE RAGRVEGRGG SITQIPILTM PNDDITHPIP DLTGFITEGQ IYVDRQLHNR QVYPPINVLP SLSRLMKSAI GEGMTRKDHG DVSNQLYACY AIGKDVQAMK AVVGEEALTS EDLLYLEFLQ KFEKNFITQG PYENRTVFES LDLGWKLLRI FPKEMLKRIP QSMTDEFYSR QGAQQDPASD TAL //