ID BZW2_MOUSE Reviewed; 419 AA. AC Q91VK1; Q9D0N4; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 19-FEB-2014, entry version 83. DE RecName: Full=Basic leucine zipper and W2 domain-containing protein 2; GN Name=Bzw2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Embryo; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Embryonic brain; RX PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200; RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; RT "Phosphoproteomic analysis of the developing mouse brain."; RL Mol. Cell. Proteomics 3:1093-1101(2004). CC -!- FUNCTION: May be involved in neuronal differentiation (By CC similarity). CC -!- SIMILARITY: Belongs to the BZW family. CC -!- SIMILARITY: Contains 1 W2 domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK011253; BAB27495.1; -; mRNA. DR EMBL; AK160544; BAE35861.1; -; mRNA. DR EMBL; BC013060; AAH13060.1; -; mRNA. DR RefSeq; NP_080116.2; NM_025840.3. DR UniGene; Mm.288669; -. DR ProteinModelPortal; Q91VK1; -. DR SMR; Q91VK1; 256-406. DR BioGrid; 211804; 1. DR IntAct; Q91VK1; 1. DR PaxDb; Q91VK1; -. DR PRIDE; Q91VK1; -. DR DNASU; 66912; -. DR Ensembl; ENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547. DR GeneID; 66912; -. DR KEGG; mmu:66912; -. DR UCSC; uc007njp.2; mouse. DR CTD; 28969; -. DR MGI; MGI:1914162; Bzw2. DR eggNOG; NOG303601; -. DR GeneTree; ENSGT00390000012561; -. DR HOGENOM; HOG000252932; -. DR HOVERGEN; HBG080940; -. DR InParanoid; Q91VK1; -. DR OMA; FMNKHQK; -. DR OrthoDB; EOG78PV8V; -. DR TreeFam; TF324313; -. DR ChiTaRS; BZW2; mouse. DR NextBio; 322995; -. DR PRO; PR:Q91VK1; -. DR ArrayExpress; Q91VK1; -. DR Bgee; Q91VK1; -. DR Genevestigator; Q91VK1; -. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW. DR Gene3D; 1.25.40.180; -; 1. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR016021; MIF4-like_typ_1/2/3. DR InterPro; IPR003307; W2_domain. DR Pfam; PF02020; W2; 1. DR SMART; SM00515; eIF5C; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS51363; W2; 1. PE 1: Evidence at protein level; KW Acetylation; Complete proteome; Developmental protein; KW Differentiation; Neurogenesis; Phosphoprotein; Reference proteome. FT CHAIN 1 419 Basic leucine zipper and W2 domain- FT containing protein 2. FT /FTId=PRO_0000254620. FT DOMAIN 248 415 W2. FT MOD_RES 117 117 N6-acetyllysine (By similarity). FT MOD_RES 412 412 Phosphoserine (By similarity). FT MOD_RES 414 414 Phosphoserine (By similarity). FT CONFLICT 69 69 F -> L (in Ref. 1; BAB27495). FT CONFLICT 326 326 A -> R (in Ref. 1; BAB27495). SQ SEQUENCE 419 AA; 48063 MW; 996FC462B50EAF6F CRC64; MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK FVEWLQNAEE ESESEGEES //