ID BZW2_MOUSE Reviewed; 419 AA. AC Q91VK1; Q9D0N4; DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-2001, sequence version 1. DT 29-SEP-2021, entry version 128. DE RecName: Full=Basic leucine zipper and W2 domain-containing protein 2; GN Name=Bzw2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Embryo; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Embryonic brain; RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200; RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; RT "Phosphoproteomic analysis of the developing mouse brain."; RL Mol. Cell. Proteomics 3:1093-1101(2004). RN [4] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brown adipose tissue, Heart, Kidney, Lung, Pancreas, and Spleen; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: May be involved in neuronal differentiation. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK011253; BAB27495.1; -; mRNA. DR EMBL; AK160544; BAE35861.1; -; mRNA. DR EMBL; BC013060; AAH13060.1; -; mRNA. DR CCDS; CCDS25884.1; -. DR RefSeq; NP_080116.2; NM_025840.3. DR SMR; Q91VK1; -. DR BioGRID; 211804; 7. DR IntAct; Q91VK1; 2. DR STRING; 10090.ENSMUSP00000020856; -. DR iPTMnet; Q91VK1; -. DR PhosphoSitePlus; Q91VK1; -. DR EPD; Q91VK1; -. DR jPOST; Q91VK1; -. DR MaxQB; Q91VK1; -. DR PaxDb; Q91VK1; -. DR PeptideAtlas; Q91VK1; -. DR PRIDE; Q91VK1; -. DR ProteomicsDB; 273781; -. DR Antibodypedia; 11817; 100 antibodies. DR DNASU; 66912; -. DR Ensembl; ENSMUST00000020856; ENSMUSP00000020856; ENSMUSG00000020547. DR GeneID; 66912; -. DR KEGG; mmu:66912; -. DR UCSC; uc007njp.2; mouse. DR CTD; 28969; -. DR MGI; MGI:1914162; Bzw2. DR VEuPathDB; HostDB:ENSMUSG00000020547; -. DR eggNOG; KOG2297; Eukaryota. DR GeneTree; ENSGT00390000012561; -. DR HOGENOM; CLU_032849_0_1_1; -. DR InParanoid; Q91VK1; -. DR OMA; EPFCNGP; -. DR OrthoDB; 653740at2759; -. DR PhylomeDB; Q91VK1; -. DR TreeFam; TF324313; -. DR BioGRID-ORCS; 66912; 3 hits in 61 CRISPR screens. DR ChiTaRS; Bzw2; mouse. DR PRO; PR:Q91VK1; -. DR Proteomes; UP000000589; Chromosome 12. DR RNAct; Q91VK1; protein. DR Bgee; ENSMUSG00000020547; Expressed in cerebral cortex and 296 other tissues. DR ExpressionAtlas; Q91VK1; baseline and differential. DR Genevisible; Q91VK1; MM. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW. DR CDD; cd11560; W2_eIF5C_like; 1. DR Gene3D; 1.25.40.180; -; 1. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR016021; MIF4-like_sf. DR InterPro; IPR043510; W2_BZW1/2. DR InterPro; IPR003307; W2_domain. DR Pfam; PF02020; W2; 1. DR SMART; SM00515; eIF5C; 1. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS51363; W2; 1. PE 1: Evidence at protein level; KW Acetylation; Developmental protein; Differentiation; Neurogenesis; KW Phosphoprotein; Reference proteome. FT CHAIN 1..419 FT /note="Basic leucine zipper and W2 domain-containing FT protein 2" FT /id="PRO_0000254620" FT DOMAIN 248..415 FT /note="W2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00695" FT REGION 1..22 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 117 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:Q9Y6E2" FT MOD_RES 412 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 414 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q9Y6E2" FT MOD_RES 419 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q9WTT7" FT CONFLICT 69 FT /note="F -> L (in Ref. 1; BAB27495)" FT /evidence="ECO:0000305" FT CONFLICT 326 FT /note="A -> R (in Ref. 1; BAB27495)" FT /evidence="ECO:0000305" SQ SEQUENCE 419 AA; 48063 MW; 996FC462B50EAF6F CRC64; MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSEAEQTK LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL VLLQKVQEYC YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHAAKG KSVFLDQMKK FVEWLQNAEE ESESEGEES //