ID Q91VB8_MOUSE Unreviewed; 142 AA. AC Q91VB8; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 05-APR-2011, entry version 91. DE SubName: Full=Alpha globin 1; DE SubName: Full=Alpha globin 2; DE SubName: Full=Alpha-globin; DE SubName: Full=Hemoglobin alpha, adult chain 1; DE SubName: Full=Hemoglobin alpha, adult chain 2; GN Name=Hba-a1; Synonyms=Hba-a2, haemaglobin alpha 1, haemaglobin alpha GN 2; ORFNames=RP23-375M9.2-001, RP23-375M9.3-001; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RX MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RG The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RX MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; RC TISSUE=Liver, Activated spleen, Whole body, Placenta, and Spleen; RX MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Liver; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RA Mashreghi-Mohammadi M.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lima_127; RX PubMed=17660536; DOI=10.1534/genetics.107.078550; RA Storz J.F., Baze M., Waite J.L., Hoffmann F.G., Opazo J.C., RA Hayes J.P.; RT "Complex signatures of selection and gene conversion in the duplicated RT globin genes of house mice."; RL Genetics 177:481-500(2007). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD; TISSUE=Activated spleen; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21096913; PubMed=11157800; DOI=10.1093/hmg/10.4.371; RA Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., RA Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., RA Alter B.P., Frischauf A.-M., Higgs D.R.; RT "Comparative genome analysis delimits a chromosomal domain and RT identifies key regulatory elements in the alpha globin cluster."; RL Hum. Mol. Genet. 10:371-382(2001). RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Liver; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [15] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Whole body, Liver, Placenta, and Spleen; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues (By similarity). CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC043020; AAH43020.1; -; mRNA. DR EMBL; AY016021; AAL32371.1; -; Genomic_DNA. DR EMBL; AY016021; AAL32372.1; -; Genomic_DNA. DR EMBL; EF605472; ABU54054.1; -; Genomic_DNA. DR EMBL; AK003077; BAB22552.1; -; mRNA. DR EMBL; AK005434; BAB24028.1; -; mRNA. DR EMBL; AK010923; BAB27269.1; -; mRNA. DR EMBL; AK010927; BAB27272.1; -; mRNA. DR EMBL; AK010933; BAB27277.1; -; mRNA. DR EMBL; AK010937; BAB27279.1; -; mRNA. DR EMBL; AK010987; BAB27307.1; -; mRNA. DR EMBL; AK011018; BAB27336.1; -; mRNA. DR EMBL; AK011023; BAB27340.1; -; mRNA. DR EMBL; AK011025; BAB27342.1; -; mRNA. DR EMBL; AK011028; BAB27344.1; -; mRNA. DR EMBL; AK011030; BAB27346.1; -; mRNA. DR EMBL; AK011055; BAB27364.1; -; mRNA. DR EMBL; AK011073; BAB27378.1; -; mRNA. DR EMBL; AK011121; BAB27414.1; -; mRNA. DR EMBL; AK012329; BAB28166.1; -; mRNA. DR EMBL; AK012348; BAB28179.1; -; mRNA. DR EMBL; AK012755; BAB28446.1; -; mRNA. DR EMBL; AK019138; BAB31564.1; -; mRNA. DR EMBL; AK028173; BAC25790.1; -; mRNA. DR EMBL; AK171893; BAE42724.1; -; mRNA. DR EMBL; AL662780; CAM22512.1; -; Genomic_DNA. DR EMBL; AL662780; CAM22514.1; -; Genomic_DNA. DR IPI; IPI00845802; -. DR RefSeq; NP_001077424.1; NM_001083955.1. DR RefSeq; NP_032244.2; NM_008218.2. DR UniGene; Mm.196110; -. DR UniGene; Mm.482094; -. DR HSSP; P01922; 1BZ1. DR ProteinModelPortal; Q91VB8; -. DR SMR; Q91VB8; 1-142. DR STRING; Q91VB8; -. DR PRIDE; Q91VB8; -. DR Ensembl; ENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917. DR Ensembl; ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919. DR GeneID; 110257; -. DR GeneID; 15122; -. DR KEGG; mmu:110257; -. DR KEGG; mmu:15122; -. DR UCSC; uc007ijk.1; mouse. DR CTD; 110257; -. DR CTD; 15122; -. DR HOVERGEN; HBG009709; -. DR InParanoid; Q91VB8; -. DR OMA; TPEVHAS; -. DR PhylomeDB; Q91VB8; -. DR NextBio; 363641; -. DR Bgee; Q91VB8; -. DR Genevestigator; Q91VB8; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR InterPro; IPR012292; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR000971; Globin_subset. DR InterPro; IPR002338; Haemoglobin_a. DR InterPro; IPR018331; Haemoglobin_alpha_chain. DR InterPro; IPR002339; Haemoglobin_pi. DR Gene3D; G3DSA:1.10.490.10; Globin_related; 1. DR PANTHER; PTHR11442:SF14; Pi_haem; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR00815; PIHAEM. DR SUPFAM; SSF46458; Globin_like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 2: Evidence at transcript level; KW Heme; Iron; Metal-binding; Oxygen transport; Transport. SQ SEQUENCE 142 AA; 15112 MW; 2F6A3712E555CB4A CRC64; MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR //