ID Q91VB8_MOUSE Unreviewed; 142 AA. AC Q91VB8; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 05-OCT-2010, entry version 86. DE SubName: Full=Alpha globin 1; DE SubName: Full=Alpha globin 2; DE SubName: Full=Alpha-globin; DE SubName: Full=Hemoglobin alpha, adult chain 1; DE SubName: Full=Hemoglobin alpha, adult chain 2; DE SubName: Full=Putative uncharacterized protein; GN Name=Hba-a1; Synonyms=Hba-a2, haemaglobin alpha 1, haemaglobin alpha GN 2; ORFNames=RP23-375M9.2-001, RP23-375M9.3-001; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J, and NOD; TISSUE=Liver, Activated spleen, Whole body, RC Placenta, and Spleen; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE. RA Mashreghi-Mohammadi M.; RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lima_127; RX PubMed=17660536; DOI=10.1534/genetics.107.078550; RA Storz J.F., Baze M., Waite J.L., Hoffmann F.G., Opazo J.C., RA Hayes J.P.; RT "Complex signatures of selection and gene conversion in the duplicated RT globin genes of house mice."; RL Genetics 177:481-500(2007). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21096913; PubMed=11157800; DOI=10.1093/hmg/10.4.371; RA Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., RA Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., RA Alter B.P., Frischauf A.-M., Higgs D.R.; RT "Comparative genome analysis delimits a chromosomal domain and RT identifies key regulatory elements in the alpha globin cluster."; RL Hum. Mol. Genet. 10:371-382(2001). CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues (By similarity). CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC043020; AAH43020.1; -; mRNA. DR EMBL; AY016021; AAL32371.1; -; Genomic_DNA. DR EMBL; AY016021; AAL32372.1; -; Genomic_DNA. DR EMBL; EF605472; ABU54054.1; -; Genomic_DNA. DR EMBL; AK003077; BAB22552.1; -; mRNA. DR EMBL; AK005434; BAB24028.1; -; mRNA. DR EMBL; AK010923; BAB27269.1; -; mRNA. DR EMBL; AK010927; BAB27272.1; -; mRNA. DR EMBL; AK010933; BAB27277.1; -; mRNA. DR EMBL; AK010937; BAB27279.1; -; mRNA. DR EMBL; AK010987; BAB27307.1; -; mRNA. DR EMBL; AK011018; BAB27336.1; -; mRNA. DR EMBL; AK011023; BAB27340.1; -; mRNA. DR EMBL; AK011025; BAB27342.1; -; mRNA. DR EMBL; AK011028; BAB27344.1; -; mRNA. DR EMBL; AK011030; BAB27346.1; -; mRNA. DR EMBL; AK011055; BAB27364.1; -; mRNA. DR EMBL; AK011073; BAB27378.1; -; mRNA. DR EMBL; AK011121; BAB27414.1; -; mRNA. DR EMBL; AK012329; BAB28166.1; -; mRNA. DR EMBL; AK012348; BAB28179.1; -; mRNA. DR EMBL; AK012755; BAB28446.1; -; mRNA. DR EMBL; AK019138; BAB31564.1; -; mRNA. DR EMBL; AK028173; BAC25790.1; -; mRNA. DR EMBL; AK171893; BAE42724.1; -; mRNA. DR EMBL; AL662780; CAM22512.1; -; Genomic_DNA. DR EMBL; AL662780; CAM22514.1; -; Genomic_DNA. DR IPI; IPI00845802; -. DR RefSeq; NP_001077424.1; -. DR RefSeq; NP_032244.2; -. DR UniGene; Mm.196110; -. DR HSSP; P01922; 1BZ1. DR ProteinModelPortal; Q91VB8; -. DR SMR; Q91VB8; 1-142. DR STRING; Q91VB8; -. DR PRIDE; Q91VB8; -. DR Ensembl; ENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917. DR Ensembl; ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919. DR GeneID; 110257; -. DR GeneID; 15122; -. DR KEGG; mmu:110257; -. DR KEGG; mmu:15122; -. DR UCSC; uc007ijk.1; mouse. DR CTD; 110257; -. DR CTD; 15122; -. DR HOVERGEN; HBG009709; -. DR InParanoid; Q91VB8; -. DR OMA; TPEVHAS; -. DR OrthoDB; EOG9X9B31; -. DR PhylomeDB; Q91VB8; -. DR NextBio; 363641; -. DR Bgee; Q91VB8; -. DR Genevestigator; Q91VB8; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR InterPro; IPR012292; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR000971; Globin_subset. DR InterPro; IPR002338; Haemoglobin_a. DR InterPro; IPR018331; Haemoglobin_alpha_chain. DR InterPro; IPR002339; Haemoglobin_pi. DR Gene3D; G3DSA:1.10.490.10; Globin_related; 1. DR PANTHER; PTHR11442:SF14; Pi_haem; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR00815; PIHAEM. DR SUPFAM; SSF46458; Globin_like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 2: Evidence at transcript level; KW Heme; Iron; Metal-binding; Oxygen transport; Transport. SQ SEQUENCE 142 AA; 15112 MW; 2F6A3712E555CB4A CRC64; MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR //