ID Q91VB8_MOUSE Unreviewed; 142 AA. AC Q91VB8; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 07-OCT-2020, entry version 185. DE SubName: Full=Alpha globin 1 {ECO:0000313|EMBL:AAL32371.1}; DE SubName: Full=Alpha globin 2 {ECO:0000313|EMBL:AAL32372.1}; DE SubName: Full=Alpha-globin {ECO:0000313|EMBL:ABU54054.1}; DE SubName: Full=Globin c1 {ECO:0000313|EMBL:SAI82198.1}; DE SubName: Full=Hemoglobin alpha, adult chain 1 {ECO:0000313|EMBL:AAH43020.1, ECO:0000313|Ensembl:ENSMUSP00000090897}; DE SubName: Full=Hemoglobin alpha, adult chain 2 {ECO:0000313|Ensembl:ENSMUSP00000090895}; GN Name=Hba-a1 {ECO:0000313|EMBL:AAH43020.1, GN ECO:0000313|Ensembl:ENSMUSP00000090897}; GN Synonyms=Glnc1 {ECO:0000313|EMBL:SAI82198.1}, haemaglobin alpha 1 GN {ECO:0000313|EMBL:AAL32371.1}, haemaglobin alpha 2 GN {ECO:0000313|EMBL:AAL32372.1}, Hba-a2 GN {ECO:0000313|Ensembl:ENSMUSP00000090895}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAB31564.1}; RN [1] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAB31564.1}, Placenta RC {ECO:0000313|EMBL:BAB24028.1}, Spleen {ECO:0000313|EMBL:BAB22552.1}, RC and Whole body {ECO:0000313|EMBL:BAB28166.1}; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., RA Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., RA Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., Imotani K., RA Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., RA Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., RA Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., RA Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., RA Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., RA Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., RA Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:AAL32371.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=11157800; DOI=10.1093/hmg/10.4.371; RA Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., RA Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., Alter B.P., RA Frischauf A.-M., Higgs D.R.; RT "Comparative genome analysis delimits a chromosomal domain and identifies RT key regulatory elements in the alpha globin cluster."; RL Hum. Mol. Genet. 10:371-382(2001). RN [6] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [7] {ECO:0000313|EMBL:BAC25790.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC25790.1}; RC TISSUE=Liver {ECO:0000313|EMBL:BAC25790.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [9] {ECO:0000313|EMBL:AAH43020.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH43020.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH43020.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [10] {ECO:0000313|EMBL:BAE42724.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K., RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [11] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [12] {ECO:0000313|EMBL:BAB31564.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAB31564.1}, and NOD RC {ECO:0000313|EMBL:BAE42724.1}; RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE42724.1}, Liver RC {ECO:0000313|EMBL:BAB31564.1}, Placenta {ECO:0000313|EMBL:BAB24028.1}, RC Spleen {ECO:0000313|EMBL:BAB22552.1}, and Whole body RC {ECO:0000313|EMBL:BAB28166.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [13] {ECO:0000313|EMBL:ABU54054.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lima_127 {ECO:0000313|EMBL:ABU54054.1}; RX PubMed=17660536; DOI=10.1534/genetics.107.078550; RA Storz J.F., Baze M., Waite J.L., Hoffmann F.G., Opazo J.C., Hayes J.P.; RT "Complex signatures of selection and gene conversion in the duplicated RT globin genes of house mice."; RL Genetics 177:481-500(2007). RN [14] {ECO:0000313|Ensembl:ENSMUSP00000090895, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000090895, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [15] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [16] {ECO:0000313|Ensembl:ENSMUSP00000090895} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000090895}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [17] {ECO:0000213|PubMed:23806337} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001; RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.; RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic RT pathways."; RL Mol. Cell 50:919-930(2013). RN [18] {ECO:0000313|EMBL:SAI82198.1} RP NUCLEOTIDE SEQUENCE. RX DOI=10.1016/j.genrep.2016.10.009; RA Premzl M.; RT "Comparative genomic analysis of eutherian globin genes."; RL Gene Rep 5:163-166(2016). RN [19] {ECO:0000313|EMBL:SAI82198.1} RP NUCLEOTIDE SEQUENCE. RX DOI=10.1016/j.genrep.2019.100414; RA Premzl M.; RT "Eutherian third-party data gene collections."; RL Gene Rep 16:100414-100414(2019). CC -!- SIMILARITY: Belongs to the globin family. CC {ECO:0000256|ARBA:ARBA00008705, ECO:0000256|PROSITE-ProRule:PRU00238, CC ECO:0000256|RuleBase:RU000356}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL662780; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC043020; AAH43020.1; -; mRNA. DR EMBL; AY016021; AAL32371.1; -; Genomic_DNA. DR EMBL; AY016021; AAL32372.1; -; Genomic_DNA. DR EMBL; EF605472; ABU54054.1; -; Genomic_DNA. DR EMBL; AK003077; BAB22552.1; -; mRNA. DR EMBL; AK005434; BAB24028.1; -; mRNA. DR EMBL; AK010923; BAB27269.1; -; mRNA. DR EMBL; AK010927; BAB27272.1; -; mRNA. DR EMBL; AK010933; BAB27277.1; -; mRNA. DR EMBL; AK010937; BAB27279.1; -; mRNA. DR EMBL; AK010987; BAB27307.1; -; mRNA. DR EMBL; AK011018; BAB27336.1; -; mRNA. DR EMBL; AK011023; BAB27340.1; -; mRNA. DR EMBL; AK011025; BAB27342.1; -; mRNA. DR EMBL; AK011028; BAB27344.1; -; mRNA. DR EMBL; AK011030; BAB27346.1; -; mRNA. DR EMBL; AK011055; BAB27364.1; -; mRNA. DR EMBL; AK011073; BAB27378.1; -; mRNA. DR EMBL; AK011121; BAB27414.1; -; mRNA. DR EMBL; AK012329; BAB28166.1; -; mRNA. DR EMBL; AK012348; BAB28179.1; -; mRNA. DR EMBL; AK012755; BAB28446.1; -; mRNA. DR EMBL; AK019138; BAB31564.1; -; mRNA. DR EMBL; AK028173; BAC25790.1; -; mRNA. DR EMBL; AK171893; BAE42724.1; -; mRNA. DR EMBL; LT548154; SAI82198.1; -; Genomic_DNA. DR RefSeq; NP_001077424.1; NM_001083955.1. DR RefSeq; NP_032244.2; NM_008218.2. DR SMR; Q91VB8; -. DR IntAct; Q91VB8; 1. DR jPOST; Q91VB8; -. DR MaxQB; Q91VB8; -. DR PRIDE; Q91VB8; -. DR DNASU; 110257; -. DR Ensembl; ENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917. DR Ensembl; ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919. DR GeneID; 110257; -. DR GeneID; 15122; -. DR KEGG; mmu:110257; -. DR KEGG; mmu:15122; -. DR UCSC; uc007ijk.1; mouse. DR CTD; 110257; -. DR CTD; 15122; -. DR MGI; MGI:96015; Hba-a1. DR MGI; MGI:96016; Hba-a2. DR GeneTree; ENSGT00940000154590; -. DR HOGENOM; CLU_003827_10_2_1; -. DR KO; K13822; -. DR OMA; FHHFDLS; -. DR OrthoDB; 1398217at2759; -. DR TreeFam; TF332328; -. DR BioGRID-ORCS; 110257; 0 hits in 14 CRISPR screens. DR BioGRID-ORCS; 15122; 1 hit in 11 CRISPR screens. DR ChiTaRS; Hba-a1; mouse. DR Proteomes; UP000000589; Chromosome 11. DR Bgee; ENSMUSG00000069917; Expressed in spleen and 48 other tissues. DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0031838; C:haptoglobin-hemoglobin complex; ISO:MGI. DR GO; GO:0005833; C:hemoglobin complex; ISO:MGI. DR GO; GO:0020037; F:heme binding; ISO:MGI. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0043177; F:organic acid binding; ISO:MGI. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW. DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI. DR GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC. DR GO; GO:0048821; P:erythrocyte development; IGI:MGI. DR GO; GO:0001701; P:in utero embryonic development; IGI:MGI. DR GO; GO:0009617; P:response to bacterium; IEP:MGI. DR CDD; cd08927; Hb-alpha_like; 1. DR Gene3D; 1.10.490.10; -; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like_sf. DR InterPro; IPR012292; Globin/Proto. DR InterPro; IPR002338; Haemoglobin_a-typ. DR InterPro; IPR002339; Haemoglobin_pi. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR00815; PIHAEM. DR SUPFAM; SSF46458; SSF46458; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 1: Evidence at protein level; KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PROSITE-ProRule:PRU00238, KW ECO:0000256|RuleBase:RU000356}; KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PROSITE-ProRule:PRU00238}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE- KW ProRule:PRU00238}; KW Oxygen transport {ECO:0000256|ARBA:ARBA00022621, ECO:0000256|PROSITE- KW ProRule:PRU00238, ECO:0000256|RuleBase:RU000356}; KW Proteomics identification {ECO:0000213|EPD:Q91VB8, KW ECO:0000213|MaxQB:Q91VB8, ECO:0000213|PeptideAtlas:Q91VB8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE- KW ProRule:PRU00238, ECO:0000256|RuleBase:RU000356}. FT DOMAIN 3..142 FT /note="GLOBIN" FT /evidence="ECO:0000259|PROSITE:PS01033" FT METAL 59 FT /note="Iron (heme distal ligand)" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00238" FT METAL 88 FT /note="Iron (heme proximal ligand)" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00238" SQ SEQUENCE 142 AA; 15112 MW; 2F6A3712E555CB4A CRC64; MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR //