ID Q91VB8_MOUSE Unreviewed; 142 AA. AC Q91VB8; DT 01-DEC-2001, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 1. DT 18-SEP-2013, entry version 114. DE SubName: Full=Alpha globin 1; DE SubName: Full=Alpha globin 2; DE SubName: Full=Alpha-globin; DE SubName: Full=Hemoglobin alpha, adult chain 1; DE SubName: Full=Hemoglobin subunit alpha; DE SubName: Full=Protein Hba-a2; GN Name=Hba-a1; Synonyms=haemaglobin alpha 1, haemaglobin alpha 2, GN Hba-a2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Liver, Placenta, Spleen, and Whole body; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Liver; RA Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., RA Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., RA Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F., RA Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., RA Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., RA Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., RA Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., RA Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., RA Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., RA Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., RA Muramatsu M., Hayashizaki Y.; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE. RX PubMed=11157800; DOI=10.1093/hmg/10.4.371; RA Flint J., Tufarelli C., Peden J., Clark K., Daniels R.J., Hardison R., RA Miller W., Philipsen S., Tan-Un K.C., McMorrow T., Frampton J., RA Alter B.P., Frischauf A.-M., Higgs D.R.; RT "Comparative genome analysis delimits a chromosomal domain and RT identifies key regulatory elements in the alpha globin cluster."; RL Hum. Mol. Genet. 10:371-382(2001). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RG The RIKEN Genome Exploration Research Group Phase II Team and the RG FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Liver; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., RA Hayashida K., Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., RA Hori F., Imotani K., Ishii Y., Itoh M., Kagawa I., Kasukawa T., RA Katoh H., Kawai J., Kojima Y., Kondo S., Konno H., Kouda M., Koya S., RA Kurihara C., Matsuyama T., Miyazaki A., Murata M., Nakamura M., RA Nishi K., Nomura K., Numazaki R., Ohno M., Ohsato N., Okazaki Y., RA Saito R., Saitoh H., Sakai C., Sakai K., Sakazume N., Sano H., RA Sasaki D., Shibata K., Shinagawa A., Shiraki T., Sogabe Y., Tagami M., RA Tagawa A., Takahashi F., Takaku-Akahira S., Takeda Y., Tanaka T., RA Tomaru A., Toya T., Yasunishi A., Muramatsu M., Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group RG Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NOD; TISSUE=Activated spleen; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RG The FANTOM Consortium, Riken Genome Exploration Research Group and RG Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [13] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J, and NOD; TISSUE=Activated spleen, Liver, Placenta RC Spleen, and Whole body; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group RG (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [14] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Lima_127; RX PubMed=17660536; DOI=10.1534/genetics.107.078550; RA Storz J.F., Baze M., Waite J.L., Hoffmann F.G., Opazo J.C., RA Hayes J.P.; RT "Complex signatures of selection and gene conversion in the duplicated RT globin genes of house mice."; RL Genetics 177:481-500(2007). RN [15] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [16] RP IDENTIFICATION. RC STRAIN=C57BL/6J; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- FUNCTION: Involved in oxygen transport from the lung to the CC various peripheral tissues (By similarity). CC -!- SIMILARITY: Belongs to the globin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL662780; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC043020; AAH43020.1; -; mRNA. DR EMBL; AY016021; AAL32371.1; -; Genomic_DNA. DR EMBL; AY016021; AAL32372.1; -; Genomic_DNA. DR EMBL; EF605472; ABU54054.1; -; Genomic_DNA. DR EMBL; AK003077; BAB22552.1; -; mRNA. DR EMBL; AK005434; BAB24028.1; -; mRNA. DR EMBL; AK010923; BAB27269.1; -; mRNA. DR EMBL; AK010927; BAB27272.1; -; mRNA. DR EMBL; AK010933; BAB27277.1; -; mRNA. DR EMBL; AK010937; BAB27279.1; -; mRNA. DR EMBL; AK010987; BAB27307.1; -; mRNA. DR EMBL; AK011018; BAB27336.1; -; mRNA. DR EMBL; AK011023; BAB27340.1; -; mRNA. DR EMBL; AK011025; BAB27342.1; -; mRNA. DR EMBL; AK011028; BAB27344.1; -; mRNA. DR EMBL; AK011030; BAB27346.1; -; mRNA. DR EMBL; AK011055; BAB27364.1; -; mRNA. DR EMBL; AK011073; BAB27378.1; -; mRNA. DR EMBL; AK011121; BAB27414.1; -; mRNA. DR EMBL; AK012329; BAB28166.1; -; mRNA. DR EMBL; AK012348; BAB28179.1; -; mRNA. DR EMBL; AK012755; BAB28446.1; -; mRNA. DR EMBL; AK019138; BAB31564.1; -; mRNA. DR EMBL; AK028173; BAC25790.1; -; mRNA. DR EMBL; AK171893; BAE42724.1; -; mRNA. DR IPI; IPI00845802; -. DR RefSeq; NP_001077424.1; NM_001083955.1. DR RefSeq; NP_032244.2; NM_008218.2. DR UniGene; Mm.196110; -. DR UniGene; Mm.459653; -. DR DNASU; 110257; -. DR Ensembl; ENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917. DR Ensembl; ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919. DR GeneID; 110257; -. DR GeneID; 15122; -. DR KEGG; mmu:110257; -. DR KEGG; mmu:15122; -. DR UCSC; uc007ijk.1; mouse. DR CTD; 110257; -. DR CTD; 15122; -. DR MGI; MGI:96015; Hba-a1. DR MGI; MGI:96016; Hba-a2. DR GeneTree; ENSGT00650000093280; -. DR HOVERGEN; HBG009709; -. DR InParanoid; Q91VB8; -. DR KO; K13822; -. DR OMA; DKFLCAV; -. DR NextBio; 287546; -. DR Genevestigator; Q91VB8; -. DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro. DR GO; GO:0020037; F:heme binding; IEA:InterPro. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0019825; F:oxygen binding; IEA:InterPro. DR GO; GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW. DR Gene3D; 1.10.490.10; -; 1. DR InterPro; IPR000971; Globin. DR InterPro; IPR009050; Globin-like. DR InterPro; IPR012292; Globin_dom. DR InterPro; IPR002338; Haemoglobin_a. DR InterPro; IPR018331; Haemoglobin_alpha_chain. DR InterPro; IPR002339; Haemoglobin_pi. DR PANTHER; PTHR11442:SF14; PTHR11442:SF14; 1. DR Pfam; PF00042; Globin; 1. DR PRINTS; PR00612; ALPHAHAEM. DR PRINTS; PR00815; PIHAEM. DR SUPFAM; SSF46458; Globin_like; 1. DR PROSITE; PS01033; GLOBIN; 1. PE 2: Evidence at transcript level; KW Complete proteome; Heme; Iron; Metal-binding; Oxygen transport; KW Reference proteome; Transport. SQ SEQUENCE 142 AA; 15112 MW; 2F6A3712E555CB4A CRC64; MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR //