ID GAT4_XENLA STANDARD; PRT; 392 AA. AC Q91677; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Transcription factor xGATA-4 (GATA binding factor-4). GN Name=GATA-4; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Gut, and Heart; RX MEDLINE=96175597; PubMed=8631498; DOI=10.1006/dbio.1996.0071; RA Jiang Y., Evans T.; RT "The Xenopus GATA-4/5/6 genes are associated with cardiac RT specification and can regulate cardiac-specific transcription during RT embryogenesis."; RL Dev. Biol. 174:258-270(1996). CC -!- FUNCTION: Associated with cardiac specification and can regulate CC cardiac-specific transcription during embryogenesis. Activates the CC expression of cardiac MHC-alpha in vivo. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- TISSUE SPECIFICITY: Expressed at high levels in heart, small CC intestine, stomach, ovary, and liver. Found at much lower levels CC in lung, spleen, pancreas and skin. CC -!- DEVELOPMENTAL STAGE: Expressed in cardiac progenitors during CC embryogenesis and up-regulated during gastrulation. CC -!- SIMILARITY: Contains 2 GATA-type zinc fingers. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U45453; AAB05647.1; -. DR HSSP; P17679; 1GNF. DR TRANSFAC; T02711; -. DR InterPro; IPR008013; GATA_N. DR InterPro; IPR000679; Znf_GATA. DR Pfam; PF00320; GATA; 2. DR Pfam; PF05349; GATA-N; 1. DR PRINTS; PR00619; GATAZNFINGER. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. KW Activator; DNA-binding; Nuclear protein; Transcription regulation; KW Zinc-finger. FT ZN_FING 184 208 GATA-type 1. FT ZN_FING 238 262 GATA-type 2. FT DOMAIN 243 247 Poly-Thr. SQ SEQUENCE 392 AA; 42353 MW; 26BFD5AEBA57C2B6 CRC64; MYQSIAMATN HGPSGYEGTG SFMHSATAAT SPVYVPTTRV SSMIHSLPYL QTSGSSQQGS PVSGHNMWAQ AGVESSAYNP GTSHPPVSPR FTFSSSPPIT APSSREVSYS SPLGISANGR EQYSRGLGAT YASPYPAYMS PDMGAAWTAS PFDSSMLHNL QNRAVTSRHP NIEFFDDFSE GRECVNCGAM STPLWRRDGT GHYLCNACGL YHKMNGINRP LIKPQRRLSA SRRVGLSCAN CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NLSKSKTLTG QSGSDSLTPS TSSTNSMGEE MRPIKIEPGL SPPYDHSNSI SQASALSTIT SHGSSYYPMP SLKLSPQNHH STFNPSPQAN SKHDSWNNLV LA //