ID GATA4_XENLA Reviewed; 392 AA. AC Q91677; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 27-MAR-2024, entry version 112. DE RecName: Full=Transcription factor GATA-4; DE AltName: Full=GATA-binding factor 4; DE Short=xGATA-4; GN Name=gata4; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RC TISSUE=Heart, and Intestine; RX PubMed=8631498; DOI=10.1006/dbio.1996.0071; RA Jiang Y., Evans T.; RT "The Xenopus GATA-4/5/6 genes are associated with cardiac specification and RT can regulate cardiac-specific transcription during embryogenesis."; RL Dev. Biol. 174:258-270(1996). CC -!- FUNCTION: Transcriptional activator that binds to the consensus CC sequence 5'-AGATAG-3'. Associated with cardiac specification and can CC regulate cardiac-specific transcription during embryogenesis. Activates CC the expression of cardiac MHC-alpha in vivo. CC {ECO:0000269|PubMed:8631498}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43694}. CC -!- TISSUE SPECIFICITY: Expressed at high levels in heart, small intestine, CC stomach, ovary, and liver. Found at much lower levels in lung, spleen, CC pancreas and skin. CC -!- DEVELOPMENTAL STAGE: Expressed in cardiac progenitors during CC embryogenesis and up-regulated during gastrulation. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U45453; AAB05647.1; -; mRNA. DR RefSeq; NP_001084098.1; NM_001090629.1. DR AlphaFoldDB; Q91677; -. DR SMR; Q91677; -. DR DNASU; 399302; -. DR GeneID; 399302; -. DR KEGG; xla:399302; -. DR AGR; Xenbase:XB-GENE-6256576; -. DR CTD; 399302; -. DR Xenbase; XB-GENE-6256576; gata4.S. DR OrthoDB; 685518at2759; -. DR Proteomes; UP000186698; Chromosome 5S. DR Bgee; 399302; Expressed in heart and 7 other cell types or tissues. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro. DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:BHF-UCL. DR GO; GO:0048738; P:cardiac muscle tissue development; IMP:BHF-UCL. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI. DR CDD; cd00202; ZnF_GATA; 2. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2. DR InterPro; IPR008013; GATA_N. DR InterPro; IPR016375; TF_GATA_4/5/6. DR InterPro; IPR039355; Transcription_factor_GATA. DR InterPro; IPR000679; Znf_GATA. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1. DR PANTHER; PTHR10071:SF154; TRANSCRIPTION FACTOR GATA-4; 1. DR Pfam; PF00320; GATA; 2. DR Pfam; PF05349; GATA-N; 1. DR PIRSF; PIRSF003028; TF_GATA_4/5/6; 1. DR PRINTS; PR00619; GATAZNFINGER. DR SMART; SM00401; ZnF_GATA; 2. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2. DR PROSITE; PS00344; GATA_ZN_FINGER_1; 2. DR PROSITE; PS50114; GATA_ZN_FINGER_2; 2. PE 2: Evidence at transcript level; KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; KW Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..392 FT /note="Transcription factor GATA-4" FT /id="PRO_0000083417" FT ZN_FING 184..208 FT /note="GATA-type 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094" FT ZN_FING 238..262 FT /note="GATA-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094" FT REGION 75..113 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 279..339 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 359..392 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 294..319 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 392 AA; 42353 MW; 26BFD5AEBA57C2B6 CRC64; MYQSIAMATN HGPSGYEGTG SFMHSATAAT SPVYVPTTRV SSMIHSLPYL QTSGSSQQGS PVSGHNMWAQ AGVESSAYNP GTSHPPVSPR FTFSSSPPIT APSSREVSYS SPLGISANGR EQYSRGLGAT YASPYPAYMS PDMGAAWTAS PFDSSMLHNL QNRAVTSRHP NIEFFDDFSE GRECVNCGAM STPLWRRDGT GHYLCNACGL YHKMNGINRP LIKPQRRLSA SRRVGLSCAN CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE GIQTRKRKPK NLSKSKTLTG QSGSDSLTPS TSSTNSMGEE MRPIKIEPGL SPPYDHSNSI SQASALSTIT SHGSSYYPMP SLKLSPQNHH STFNPSPQAN SKHDSWNNLV LA //