ID Q90VU7_9HIV1 PRELIMINARY; PRT; 206 AA. AC Q90VU7; DT 01-DEC-2001 (TrEMBLrel. 19, Created) DT 01-DEC-2001 (TrEMBLrel. 19, Last sequence update) DT 01-OCT-2003 (TrEMBLrel. 25, Last annotation update) DE NEF protein. GN Name=nef; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NL4-3; RX MEDLINE=96036482; PubMed=7483282; RA Salminen M.O., Koch C., Sanders-Buell E., Ehrenberg P.K., RA Michael N.L., Carr J.K., Burke D.S., McCutchan F.E.; RT "Recovery of virtually full-length HIV-1 provirus of diverse subtypes RT from primary virus cultures using the polymerase chain reaction."; RL Virology 213:80-86(1995). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NL4-3; RX MEDLINE=86281827; PubMed=3016298; RA Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., RA Martin M.A.; RT "Production of acquired immunodeficiency syndrome-associated RT retrovirus in human and nonhuman cells transfected with an infectious RT molecular clone."; RL J. Virol. 59:284-291(1986). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NL4-3; RA Salminen M.S.; RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases. RN [4] RP PROTEIN SEQUENCE. RX PubMed=9126340; RA Macreadie I.G., Lowe M.G., Curtain C.C., Hewish D., Azad A.A.; RT "Cytotoxicity resulting from addition of HIV-1 Nef N-terminal peptides RT to yeast and bacterial cells."; RL Biochem. Biophys. Res. Commun. 232:707-711(1997). RN [5] RP NUCLEOTIDE SEQUENCE. RX PubMed=1629704; RA Smith J., Azad A., Deacon N.; RT "Identification of two novel human immunodeficiency virus type 1 RT splice acceptor sites in infected T cell lines."; RL J. Gen. Virol. 73 ( Pt 7):1825-1828(1992). RN [6] RP PROTEIN SEQUENCE. RX PubMed=8174561; RA Freund J., Kellner R., Houthaeve T., Kalbitzer H.R.; RT "Stability and proteolytic domains of Nef protein from human RT immunodeficiency virus (HIV) type 1."; RL Eur. J. Biochem. 221:811-819(1994). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U26942; AAB60579.1; -; Genomic_DNA. DR PIR; JC5400; JC5400. DR PIR; JQ1620; JQ1620. DR PIR; S03244; S03244. DR PIR; S43467; S43467. DR HSSP; P03406; 1AVZ. DR SMR; Q90VU7; 2-57, 56-205. DR GO; GO:0005525; F:GTP binding; IEA. DR InterPro; IPR001558; HIV_Nef. DR Pfam; PF00469; F-protein; 1. DR ProDom; PD000031; HIV_Nef; 1. SQ SEQUENCE 206 AA; 23367 MW; 65AF3B6184DC2FE7 CRC64; MGGKWSKSSV IGWPAVRERM RRAEPAADGV GAVSRDLEKH GAITSSNTAA NNAACAWLEA QEEEEVGFPV TPQVPLRPMT YKAAVDLSHF LKEKGGLEGL IHSQRRQDIL DLWIYHTQGY FPDWQNYTPG PGVRYPLTFG WCYKLVPVEP DKVEEANKGE NTSLLHPVSL HGMDDPEREV LEWRFDSRLA FHHVARELHP EYFKNC //