ID Q90491_BRARE Unreviewed; 583 AA. AC Q90491; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 12-DEC-2006, entry version 51. DE DNA binding protein E12. GN Name=e12; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=WT; TISSUE=Whole embryo; RX MEDLINE=95001558; PubMed=7918099; DOI=10.1016/0925-4773(94)90077-9; RA Wulbeck C., Fromental-Ramain C., Campos-Ortega J.A.; RT "The HLH domain of a zebrafish HE12 homologue can partially substitute RT for functions of the HLH domain of Drosophila DAUGHTERLESS."; RL Mech. Dev. 46:73-85(1994). CC -!- FUNCTION: Sequence-specific transcription factor which is part of CC a developmental regulatory system that provides cells with CC specific positional identities on the anterior-posterior axis (By CC similarity). CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X76997; CAA54305.1; -; mRNA. DR PIR; I50518; I50518. DR UniGene; Dr.20061; -. DR Ensembl; ENSDARG00000005915; Danio rerio. DR ZFIN; ZDB-GENE-990415-51; e12. DR ArrayExpress; Q90491; -. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0030528; F:transcription regulator activity; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. DR InterPro; IPR001092; HLH_basic. DR InterPro; IPR011598; HLH_DNA_bd. DR InterPro; IPR009057; Homeodomain_like. DR Gene3D; G3DSA:4.10.280.10; HLH_DNA_bd; 1. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR PROSITE; PS50888; HLH; 1. KW DNA-binding. SQ SEQUENCE 583 AA; 62626 MW; 2BDC4EDB81E74F44 CRC64; MATVGTDMEL NDLLDFSIMF PHPMSNGKSR GPNIPSSQFG LDDRNDSGSW GSEANSPSFG ARLYGDGHHY PEHDNMYNLE IDGKSERGYP VTQLLPGEIN IAASDALSPP GMKGSSQFYS PHRRRPAESS IDPLPKKRKV PHGLPTSISA YPGSTGDDYN QDSAGYPGSK PGNLYPGFFN VQEGLPDHWG QSGYPPVMSN FINPQKPQPL PVSPQNYPLH GSEVNLPSSF HSVPAGYGVP NHTPPISSSE GIMGNRGANA GSSGAEIGKA LASIYPSDNN GSNFSSTPST PVGSPSNVAA SASQWPKGSS QPAPSPGFEA GLAQSKLDDR LGEALHVLRN HHAVGTDMQS LLSAAISGHS AGAAALGSLR QAFGLANRLP GLMSNHSEDA AGLPQSSALL QGHHTSHQPP PSSQSDTFTS LSLARSSHAS SSDIKREDKD DDENLSIADK SEDEKKDGKS RTRTSQDEDE DEDDEDLPVE VKAERERERR MANNARERLR VRDINEAFKE LGRMCQLHLS NEKPQTKLLI LHQAVNVILN LEQQVRERNL NPKAACLKRR EEEKVTGEAQ MLSGLGGDGH AHM //