ID Q90491_DANRE Unreviewed; 583 AA. AC Q90491; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 25-MAY-2022, entry version 146. DE SubName: Full=DNA binding protein E12 {ECO:0000313|EMBL:CAA54305.1}; GN Name=tcf3a {ECO:0000313|ZFIN:ZDB-GENE-990415-51}; GN Synonyms=e12 {ECO:0000313|ZFIN:ZDB-GENE-990415-51}, tcf3 GN {ECO:0000313|ZFIN:ZDB-GENE-990415-51}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAA54305.1}; RN [1] {ECO:0000313|EMBL:CAA54305.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WT {ECO:0000313|EMBL:CAA54305.1}; RC TISSUE=Whole embryo {ECO:0000313|EMBL:CAA54305.1}; RX PubMed=7918099; DOI=10.1016/0925-4773(94)90077-9; RA Wuelbeck C, Fromental-Ramain C, Campos-Ortega JAA; RT "The HLH domain of a zebrafish HE12 homologue can partially substitute for RT functions of the HLH domain of Drosophila DAUGHTERLESS."; RL Mech. Dev. 46:73-85(1994). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X76997; CAA54305.1; -; mRNA. DR PIR; I50518; I50518. DR RefSeq; NP_571169.1; NM_131094.1. DR GeneID; 30310; -. DR KEGG; dre:30310; -. DR CTD; 30310; -. DR ZFIN; ZDB-GENE-990415-51; tcf3a. DR OrthoDB; 571132at2759; -. DR PhylomeDB; Q90491; -. DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0055002; P:striated muscle cell development; IMP:ZFIN. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 2: Evidence at transcript level; FT DOMAIN 488..541 FT /note="BHLH" FT /evidence="ECO:0000259|PROSITE:PS50888" FT REGION 25..56 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 105..166 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 281..321 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 400..489 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 29..56 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 125..139 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 148..162 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 281..311 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 400..429 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 430..466 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 583 AA; 62626 MW; 2BDC4EDB81E74F44 CRC64; MATVGTDMEL NDLLDFSIMF PHPMSNGKSR GPNIPSSQFG LDDRNDSGSW GSEANSPSFG ARLYGDGHHY PEHDNMYNLE IDGKSERGYP VTQLLPGEIN IAASDALSPP GMKGSSQFYS PHRRRPAESS IDPLPKKRKV PHGLPTSISA YPGSTGDDYN QDSAGYPGSK PGNLYPGFFN VQEGLPDHWG QSGYPPVMSN FINPQKPQPL PVSPQNYPLH GSEVNLPSSF HSVPAGYGVP NHTPPISSSE GIMGNRGANA GSSGAEIGKA LASIYPSDNN GSNFSSTPST PVGSPSNVAA SASQWPKGSS QPAPSPGFEA GLAQSKLDDR LGEALHVLRN HHAVGTDMQS LLSAAISGHS AGAAALGSLR QAFGLANRLP GLMSNHSEDA AGLPQSSALL QGHHTSHQPP PSSQSDTFTS LSLARSSHAS SSDIKREDKD DDENLSIADK SEDEKKDGKS RTRTSQDEDE DEDDEDLPVE VKAERERERR MANNARERLR VRDINEAFKE LGRMCQLHLS NEKPQTKLLI LHQAVNVILN LEQQVRERNL NPKAACLKRR EEEKVTGEAQ MLSGLGGDGH AHM //