ID Q90491_DANRE Unreviewed; 583 AA. AC Q90491; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 31-JUL-2019, entry version 138. DE SubName: Full=DNA binding protein E12 {ECO:0000313|EMBL:CAA54305.1}; GN Name=tcf3a {ECO:0000313|ZFIN:ZDB-GENE-990415-51}; GN Synonyms=e12 {ECO:0000313|ZFIN:ZDB-GENE-990415-51}, tcf3 GN {ECO:0000313|ZFIN:ZDB-GENE-990415-51}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAA54305.1}; RN [1] {ECO:0000313|EMBL:CAA54305.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WT {ECO:0000313|EMBL:CAA54305.1}; RC TISSUE=Whole embryo {ECO:0000313|EMBL:CAA54305.1}; RX PubMed=7918099; DOI=10.1016/0925-4773(94)90077-9; RA Wuelbeck C, Fromental-Ramain C, Campos-Ortega JAA; RT "The HLH domain of a zebrafish HE12 homologue can partially substitute RT for functions of the HLH domain of Drosophila DAUGHTERLESS."; RL Mech. Dev. 46:73-85(1994). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X76997; CAA54305.1; -; mRNA. DR PIR; I50518; I50518. DR RefSeq; NP_571169.1; NM_131094.1. DR GeneID; 30310; -. DR KEGG; dre:30310; -. DR CTD; 30310; -. DR ZFIN; ZDB-GENE-990415-51; tcf3a. DR eggNOG; KOG3910; Eukaryota. DR eggNOG; ENOG410XYUA; LUCA. DR HOGENOM; HOG000234180; -. DR OrthoDB; 571132at2759; -. DR PhylomeDB; Q90491; -. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0043425; F:bHLH transcription factor binding; IBA:GO_Central. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central. DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0055002; P:striated muscle cell development; IMP:ZFIN. DR CDD; cd00083; HLH; 1. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR InterPro; IPR036638; HLH_DNA-bd_sf. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 2: Evidence at transcript level; FT DOMAIN 488 541 BHLH. {ECO:0000259|PROSITE:PS50888}. FT REGION 25 56 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 105 166 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 281 321 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 400 489 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 29 56 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 125 139 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 148 162 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 281 311 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 400 429 Polar. {ECO:0000256|SAM:MobiDB-lite}. FT COMPBIAS 430 466 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. SQ SEQUENCE 583 AA; 62626 MW; 2BDC4EDB81E74F44 CRC64; MATVGTDMEL NDLLDFSIMF PHPMSNGKSR GPNIPSSQFG LDDRNDSGSW GSEANSPSFG ARLYGDGHHY PEHDNMYNLE IDGKSERGYP VTQLLPGEIN IAASDALSPP GMKGSSQFYS PHRRRPAESS IDPLPKKRKV PHGLPTSISA YPGSTGDDYN QDSAGYPGSK PGNLYPGFFN VQEGLPDHWG QSGYPPVMSN FINPQKPQPL PVSPQNYPLH GSEVNLPSSF HSVPAGYGVP NHTPPISSSE GIMGNRGANA GSSGAEIGKA LASIYPSDNN GSNFSSTPST PVGSPSNVAA SASQWPKGSS QPAPSPGFEA GLAQSKLDDR LGEALHVLRN HHAVGTDMQS LLSAAISGHS AGAAALGSLR QAFGLANRLP GLMSNHSEDA AGLPQSSALL QGHHTSHQPP PSSQSDTFTS LSLARSSHAS SSDIKREDKD DDENLSIADK SEDEKKDGKS RTRTSQDEDE DEDDEDLPVE VKAERERERR MANNARERLR VRDINEAFKE LGRMCQLHLS NEKPQTKLLI LHQAVNVILN LEQQVRERNL NPKAACLKRR EEEKVTGEAQ MLSGLGGDGH AHM //