ID Q90491_DANRE Unreviewed; 583 AA. AC Q90491; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 09-DEC-2015, entry version 118. DE SubName: Full=DNA binding protein E12 {ECO:0000313|EMBL:CAA54305.1}; GN Name=tcf3a {ECO:0000313|ZFIN:ZDB-GENE-990415-51}; GN Synonyms=e12 {ECO:0000313|ZFIN:ZDB-GENE-990415-51}, tcf3 GN {ECO:0000313|ZFIN:ZDB-GENE-990415-51}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:CAA54305.1}; RN [1] {ECO:0000313|EMBL:CAA54305.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=WT {ECO:0000313|EMBL:CAA54305.1}; RC TISSUE=Whole embryo {ECO:0000313|EMBL:CAA54305.1}; RX PubMed=7918099; DOI=10.1016/0925-4773(94)90077-9; RA Wuelbeck C., Fromental-Ramain C., Campos-Ortega J.A.; RT "The HLH domain of a zebrafish HE12 homologue can partially substitute RT for functions of the HLH domain of Drosophila DAUGHTERLESS."; RL Mech. Dev. 46:73-85(1994). CC -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. CC {ECO:0000256|RuleBase:RU000367}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X76997; CAA54305.1; -; mRNA. DR PIR; I50518; I50518. DR RefSeq; NP_571169.1; NM_131094.1. DR UniGene; Dr.20061; -. DR ProteinModelPortal; Q90491; -. DR STRING; 7955.ENSDARP00000010044; -. DR PaxDb; Q90491; -. DR PRIDE; Q90491; -. DR GeneID; 30310; -. DR KEGG; dre:30310; -. DR CTD; 30310; -. DR ZFIN; ZDB-GENE-990415-51; tcf3a. DR eggNOG; ENOG410XYUA; LUCA. DR eggNOG; KOG3910; Eukaryota. DR HOGENOM; HOG000234180; -. DR HOVERGEN; HBG003854; -. DR PhylomeDB; Q90491; -. DR NextBio; 20806750; -. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0005667; C:transcription factor complex; IBA:GO_Central. DR GO; GO:0043425; F:bHLH transcription factor binding; IBA:GO_Central. DR GO; GO:0046982; F:protein heterodimerization activity; IBA:GO_Central. DR GO; GO:0042803; F:protein homodimerization activity; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN. DR GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0045666; P:positive regulation of neuron differentiation; IBA:GO_Central. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:GO_Central. DR GO; GO:0055002; P:striated muscle cell development; IMP:ZFIN. DR Gene3D; 4.10.280.10; -; 1. DR InterPro; IPR011598; bHLH_dom. DR Pfam; PF00010; HLH; 1. DR SMART; SM00353; HLH; 1. DR SUPFAM; SSF47459; SSF47459; 1. DR PROSITE; PS50888; BHLH; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}. FT DOMAIN 488 541 BHLH (basic helix-loop-helix). FT {ECO:0000259|PROSITE:PS50888}. FT COILED 482 502 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 583 AA; 62626 MW; 2BDC4EDB81E74F44 CRC64; MATVGTDMEL NDLLDFSIMF PHPMSNGKSR GPNIPSSQFG LDDRNDSGSW GSEANSPSFG ARLYGDGHHY PEHDNMYNLE IDGKSERGYP VTQLLPGEIN IAASDALSPP GMKGSSQFYS PHRRRPAESS IDPLPKKRKV PHGLPTSISA YPGSTGDDYN QDSAGYPGSK PGNLYPGFFN VQEGLPDHWG QSGYPPVMSN FINPQKPQPL PVSPQNYPLH GSEVNLPSSF HSVPAGYGVP NHTPPISSSE GIMGNRGANA GSSGAEIGKA LASIYPSDNN GSNFSSTPST PVGSPSNVAA SASQWPKGSS QPAPSPGFEA GLAQSKLDDR LGEALHVLRN HHAVGTDMQS LLSAAISGHS AGAAALGSLR QAFGLANRLP GLMSNHSEDA AGLPQSSALL QGHHTSHQPP PSSQSDTFTS LSLARSSHAS SSDIKREDKD DDENLSIADK SEDEKKDGKS RTRTSQDEDE DEDDEDLPVE VKAERERERR MANNARERLR VRDINEAFKE LGRMCQLHLS NEKPQTKLLI LHQAVNVILN LEQQVRERNL NPKAACLKRR EEEKVTGEAQ MLSGLGGDGH AHM //