ID TM190_HUMAN Reviewed; 177 AA. AC Q8WZ59; A6NJL5; DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 29-APR-2015, entry version 76. DE RecName: Full=Transmembrane protein 190; DE Flags: Precursor; GN Name=TMEM190; Synonyms=MDAC1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Gong L., Wu K.; RT "Identification of MDAC1, a novel gene located on human chromosome RT 19."; RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC Q07108:CD69; NbExp=3; IntAct=EBI-10278423, EBI-2836595; CC P0C7H8:KRTAP2-3; NbExp=3; IntAct=EBI-10278423, EBI-10196781; CC Q5T700:LDLRAD1; NbExp=3; IntAct=EBI-10278423, EBI-10173166; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I CC membrane protein {ECO:0000250}. CC -!- SIMILARITY: Contains 1 P-type (trefoil) domain. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF442729; AAL35294.1; -; mRNA. DR EMBL; AC020922; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471135; EAW72372.1; -; Genomic_DNA. DR EMBL; BC128189; AAI28190.1; -; mRNA. DR EMBL; BC128190; AAI28191.1; -; mRNA. DR CCDS; CCDS33113.1; -. DR RefSeq; NP_631911.1; NM_139172.1. DR UniGene; Hs.590943; -. DR ProteinModelPortal; Q8WZ59; -. DR BioGrid; 127085; 3. DR IntAct; Q8WZ59; 3. DR STRING; 9606.ENSP00000291934; -. DR PhosphoSite; Q8WZ59; -. DR BioMuta; TMEM190; -. DR DMDM; 74716581; -. DR PaxDb; Q8WZ59; -. DR PRIDE; Q8WZ59; -. DR Ensembl; ENST00000291934; ENSP00000291934; ENSG00000160472. DR GeneID; 147744; -. DR KEGG; hsa:147744; -. DR UCSC; uc002qkt.1; human. DR CTD; 147744; -. DR GeneCards; GC19P055888; -. DR HGNC; HGNC:29632; TMEM190. DR HPA; HPA026899; -. DR neXtProt; NX_Q8WZ59; -. DR PharmGKB; PA162406247; -. DR eggNOG; NOG45666; -. DR GeneTree; ENSGT00390000006710; -. DR HOGENOM; HOG000154618; -. DR HOVERGEN; HBG094948; -. DR InParanoid; Q8WZ59; -. DR OMA; WTCGGLL; -. DR OrthoDB; EOG7HQN9H; -. DR PhylomeDB; Q8WZ59; -. DR TreeFam; TF337652; -. DR GenomeRNAi; 147744; -. DR NextBio; 85720; -. DR PRO; PR:Q8WZ59; -. DR Proteomes; UP000005640; Chromosome 19. DR Bgee; Q8WZ59; -. DR CleanEx; HS_TMEM190; -. DR Genevestigator; Q8WZ59; -. DR GO; GO:0002079; C:inner acrosomal membrane; IEA:Ensembl. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005634; C:nucleus; IDA:UniProtKB. DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl. DR InterPro; IPR000519; P_trefoil. DR InterPro; IPR028248; TMEM190. DR Pfam; PF15431; TMEM190; 1. DR SUPFAM; SSF57492; SSF57492; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Membrane; Reference proteome; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1 21 {ECO:0000255}. FT CHAIN 22 177 Transmembrane protein 190. FT /FTId=PRO_0000312282. FT TOPO_DOM 22 81 Extracellular. {ECO:0000255}. FT TRANSMEM 82 102 Helical. {ECO:0000255}. FT TOPO_DOM 103 177 Cytoplasmic. {ECO:0000255}. FT DOMAIN 31 71 P-type. FT COMPBIAS 165 176 Poly-Glu. FT DISULFID 33 61 {ECO:0000250}. FT DISULFID 43 60 {ECO:0000250}. FT DISULFID 55 67 {ECO:0000250}. SQ SEQUENCE 177 AA; 19457 MW; 618E843FFE8FC511 CRC64; MLGCGIPALG LLLLLQGSAD GNGIQGFFYP WSCEGDIWDR ESCGGQAAID SPNLCLRLRC CYRNGVCYHQ RPDENVRRKH MWALVWTCSG LLLLSCSICL FWWAKRRDVL HMPGFLAGPC DMSKSVSLLS KHRGTKKTPS TGSVPVALSK ESRDVEGGTE GEGTEEGEET EGEEEED //