ID TM190_HUMAN Reviewed; 177 AA. AC Q8WZ59; A6NJL5; DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 05-OCT-2010, entry version 45. DE RecName: Full=Transmembrane protein 190; DE Flags: Precursor; GN Name=TMEM190; Synonyms=MDAC1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Gong L., Wu K.; RT "Identification of MDAC1, a novel gene located on human chromosome RT 19."; RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., RA Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., RA Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., RA Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., RA Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., RA Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., RA Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., RA Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., RA Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., RA Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., RA Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., RA Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., RA Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., RA Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., RA Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., RA Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein (Potential). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF442729; AAL35294.1; -; mRNA. DR EMBL; AC020922; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471135; EAW72372.1; -; Genomic_DNA. DR EMBL; BC128189; AAI28190.1; -; mRNA. DR EMBL; BC128190; AAI28191.1; -; mRNA. DR IPI; IPI00103847; -. DR RefSeq; NP_631911.1; -. DR UniGene; Hs.590943; -. DR ProteinModelPortal; Q8WZ59; -. DR STRING; Q8WZ59; -. DR PRIDE; Q8WZ59; -. DR Ensembl; ENST00000291934; ENSP00000291934; ENSG00000160472. DR GeneID; 147744; -. DR KEGG; hsa:147744; -. DR UCSC; uc002qkt.1; human. DR CTD; 147744; -. DR GeneCards; GC19P055888; -. DR HGNC; HGNC:29632; TMEM190. DR HPA; HPA026899; -. DR eggNOG; prNOG19947; -. DR HOGENOM; HBG126935; -. DR HOVERGEN; HBG094948; -. DR InParanoid; Q8WZ59; -. DR OMA; WWAKRRD; -. DR OrthoDB; EOG969TDX; -. DR NextBio; 85720; -. DR ArrayExpress; Q8WZ59; -. DR Bgee; Q8WZ59; -. DR CleanEx; HS_TMEM190; -. DR Genevestigator; Q8WZ59; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR InterPro; IPR000519; P_trefoil. DR SUPFAM; SSF57492; P_trefoil; 1. PE 2: Evidence at transcript level; KW Complete proteome; Membrane; Signal; Transmembrane; KW Transmembrane helix. FT SIGNAL 1 21 Potential. FT CHAIN 22 177 Transmembrane protein 190. FT /FTId=PRO_0000312282. FT TOPO_DOM 22 81 Extracellular (Potential). FT TRANSMEM 82 102 Helical; (Potential). FT TOPO_DOM 103 177 Cytoplasmic (Potential). FT COMPBIAS 165 176 Poly-Glu. SQ SEQUENCE 177 AA; 19457 MW; 618E843FFE8FC511 CRC64; MLGCGIPALG LLLLLQGSAD GNGIQGFFYP WSCEGDIWDR ESCGGQAAID SPNLCLRLRC CYRNGVCYHQ RPDENVRRKH MWALVWTCSG LLLLSCSICL FWWAKRRDVL HMPGFLAGPC DMSKSVSLLS KHRGTKKTPS TGSVPVALSK ESRDVEGGTE GEGTEEGEET EGEEEED //