ID BAALC_HUMAN Reviewed; 179 AA. AC Q8WXS3; Q8WTP6; Q8WXS0; Q8WXS1; Q8WXS2; Q9HA93; DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot. DT 05-SEP-2006, sequence version 2. DT 28-NOV-2006, entry version 17. DE Brain and acute leukemia cytoplasmic protein. GN Name=BAALC; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6), SUBCELLULAR RP LOCATION, AND TISSUE SPECIFICITY. RX MEDLINE=21574584; PubMed=11707601; DOI=10.1073/pnas.241525498; RA Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., RA Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., RA Caligiuri M.A., Bloomfield C.D., de La Chapelle A.; RT "BAALC, the human member of a novel mammalian neuroectoderm gene RT lineage, is implicated in hematopoiesis and acute leukemia."; RL Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Embryo; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May play a synaptic role at the postsynaptic lipid rafts CC by interacting with CAMK2A (By similarity). CC -!- SUBUNIT: Interacts with CAMK2A (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane. Postsynaptic lipid CC rafts (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=6; CC Name=1; Synonyms=1-5-6-8; CC IsoId=Q8WXS3-1; Sequence=Displayed; CC Name=2; Synonyms=1-6-8; CC IsoId=Q8WXS3-2; Sequence=VSP_020196; CC Name=3; Synonyms=1-5-6-7-8; CC IsoId=Q8WXS3-3; Sequence=VSP_020197, VSP_020198; CC Name=4; Synonyms=1-2; CC IsoId=Q8WXS3-4; Sequence=VSP_020199, VSP_020200; CC Name=5; Synonyms=1-4-5-6-8; CC IsoId=Q8WXS3-5; Sequence=VSP_020201, VSP_020202; CC Name=6; Synonyms=1-8; CC IsoId=Q8WXS3-6; Sequence=VSP_020203, VSP_020204; CC -!- TISSUE SPECIFICITY: Expressed by neural and hematopoietic cells. CC Expression is found both in normal early progenitor cells and in CC the most immature type of blasts in acute leukemia but not in CC mature hematopoietic cells. Isoform 2 and isoform 6 are expressed CC in the brain. Isoform 2 shows a low expression in neuroectoderm- CC derived tissues such as adrenal gland and no expression in bone CC marrow, peripheral blood lymphocytes or lymph nodes, or in tumors CC or cancer cell lines of nonneural tissue origin. CC -!- PTM: Palmitoylation and myristoylation target the protein to the CC lipid rafts (By similarity). CC -!- WEB RESOURCE: NAME=Atlas of Genetics and Cytogenetics in Oncology CC and Haematology; CC URL="http://atlasgeneticsoncology.org/Genes/BAALCID739ch8q22.html". CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF371319; AAL50515.1; -; mRNA. DR EMBL; AF371323; AAL50519.1; -; mRNA. DR EMBL; AF363578; AAL50377.1; -; Genomic_DNA. DR EMBL; AF363578; AAL50378.1; -; Genomic_DNA. DR EMBL; AF363578; AAL50379.1; -; Genomic_DNA. DR EMBL; AF363578; AAL50380.1; -; Genomic_DNA. DR EMBL; AF363578; AAL50381.1; -; Genomic_DNA. DR EMBL; AF363578; AAL50382.1; -; Genomic_DNA. DR EMBL; AK022077; BAB13960.1; -; mRNA. DR EMBL; BC011517; AAH11517.1; -; mRNA. DR EMBL; BC035038; AAH35038.1; -; mRNA. DR Ensembl; ENSG00000164929; Homo sapiens. DR HGNC; HGNC:14333; BAALC. DR MIM; 606602; gene. DR ArrayExpress; Q8WXS3; -. DR RZPD-ProtExp; IOH9655; -. DR RZPD-ProtExp; RZPDo839D10153; -. DR RZPD-ProtExp; RZPDo839D10154; -. DR RZPD-ProtExp; W1939; -. KW Alternative splicing; Lipoprotein; Membrane; Myristate; Palmitate. FT INIT_MET 0 0 By similarity. FT CHAIN 1 179 Brain and acute leukemia cytoplasmic FT protein. FT /FTId=PRO_0000248205. FT REGION 3 35 Interaction with CAMK2A (By similarity). FT LIPID 1 1 N-myristoyl glycine (By similarity). FT LIPID 2 2 S-palmitoyl cysteine (By similarity). FT VAR_SEQ 53 87 Missing (in isoform 2). FT /FTId=VSP_020196. FT VAR_SEQ 53 79 VLEAEKSKIKAPTDSVSDEGLFSASKM -> AHYPLAFALA FT WRDNSLGALLVQEGLCR (in isoform 4). FT /FTId=VSP_020199. FT VAR_SEQ 53 72 VLEAEKSKIKAPTDSVSDEG -> GCLEEHYHLTALQKVGH FT PNH (in isoform 5). FT /FTId=VSP_020201. FT VAR_SEQ 53 53 V -> G (in isoform 6). FT /FTId=VSP_020203. FT VAR_SEQ 54 179 Missing (in isoform 6). FT /FTId=VSP_020204. FT VAR_SEQ 73 179 Missing (in isoform 5). FT /FTId=VSP_020202. FT VAR_SEQ 80 179 Missing (in isoform 4). FT /FTId=VSP_020200. FT VAR_SEQ 144 148 AKRDA -> VLLPS (in isoform 3). FT /FTId=VSP_020197. FT VAR_SEQ 149 179 Missing (in isoform 3). FT /FTId=VSP_020198. SQ SEQUENCE 179 AA; 19093 MW; D501CED4AC0A444F CRC64; GCGGSRADAI EPRYYESWTR ETESTWLTYT DSDAPPSAAA PDSGPEAGGL HSVLEAEKSK IKAPTDSVSD EGLFSASKMA PLAVFSHGML EDGLPSNGVP RSTAPGGIPN PEKKTNCETQ CPNPQSLSSG PLTQKQNGLQ TTEAKRDAKR MPAKEVTINV TDSIQQMDRS RRITKNCVN //