ID CNKR2_HUMAN STANDARD; PRT; 1034 AA. AC Q8WXI2; O94976; Q8WXI1; DT 25-OCT-2004 (Rel. 45, Created) DT 25-OCT-2004 (Rel. 45, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Connector enhancer of kinase suppressor of ras 2 (Connector enhancer DE of KSR2) (CNK2). GN Name=CNKSR2; Synonyms=CNK2, KIAA0902, KSR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2), FUNCTION, INTERACTIONS WITH RP RAF1, RAB2L AND RAL GTPASE PROTEINS, AND PHOSPHORYLATION. RC TISSUE=Fetal brain; RX PubMed=14597674; DOI=10.1096/fj.02-1096com; RA Lanigan T.M., Liu A., Huang Y.Z., Mei L., Margolis B., Guan K.-L.; RT "Human homologue of Drosophila CNK interacts with Ras effector RT proteins Raf and Rlf."; RL FASEB J. 17:2048-2060(2003). RN [2] RP NUCLEOTIDE SEQUENCE (ISOFORM 3). RC TISSUE=Brain; RX MEDLINE=99156230; PubMed=10048485; RA Nagase T., Ishikawa K.-I., Suyama M., Kikuno R., Hirosawa M., RA Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. XII. RT The complete sequences of 100 new cDNA clones from brain which code RT for large proteins in vitro."; RL DNA Res. 5:355-364(1998). CC -!- FUNCTION: May function as an adapter protein or regulator of Ras CC signaling pathways. CC -!- SUBUNIT: Interacts with RAF1, RAB2L and RAL GTPase proteins. CC -!- SUBCELLULAR LOCATION: Cytoplasmic and membrane-associated. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; Synonyms=CNK2A, KSR2A; CC IsoId=Q8WXI2-1; Sequence=Displayed; CC Name=2; Synonyms=CNK2B, KSR2B; CC IsoId=Q8WXI2-2; Sequence=VSP_010887; CC Name=3; CC IsoId=Q8WXI2-3; Sequence=VSP_010888, VSP_010889; CC Note=No experimental confirmation available; CC -!- PTM: Phosphorylated on tyrosine. CC -!- SIMILARITY: Contains 1 CRIC domain. CC -!- SIMILARITY: Contains 1 DUF1170 domain. CC -!- SIMILARITY: Contains 1 PDZ/DHR domain. CC -!- SIMILARITY: Contains 1 PH domain. CC -!- SIMILARITY: Contains 1 sterile alpha motif (SAM) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF418269; AAL60502.1; -. DR EMBL; AF418270; AAL60503.1; -. DR EMBL; AB020709; BAA74925.2; ALT_INIT. DR Ensembl; ENSG00000149970; Homo sapiens. DR Genew; HGNC:19701; CNKSR2. DR InterPro; IPR010599; DUF1170. DR InterPro; IPR001478; PDZ. DR InterPro; IPR001849; PH. DR InterPro; IPR001660; SAM. DR Pfam; PF06663; DUF1170; 1. DR Pfam; PF00595; PDZ; 1. DR Pfam; PF00169; PH; 1. DR Pfam; PF00536; SAM; 1. DR SMART; SM00228; PDZ; 1. DR SMART; SM00233; PH; 1. DR SMART; SM00454; SAM; 1. DR PROSITE; PS50106; PDZ; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. DR PROSITE; PS50105; SAM_DOMAIN; 1. KW Alternative splicing; Coiled coil; Membrane; Phosphorylation. FT DOMAIN 11 76 SAM. FT DOMAIN 84 178 CRIC. FT DOMAIN 215 297 PDZ. FT DOMAIN 332 515 DUF1170. FT DOMAIN 570 669 PH. FT DOMAIN 354 357 Poly-Pro. FT DOMAIN 703 706 Poly-Pro. FT DOMAIN 875 904 Coiled coil (Potential). FT DOMAIN 875 888 Poly-Glu. FT VARSPLIC 899 1034 Missing (in isoform 2). FT /FTId=VSP_010887. FT VARSPLIC 859 893 NAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGEN -> ML FT QLVPVTHRMTCNPQRWRKRRRRRRRKGRQQGKT (in FT isoform 3). FT /FTId=VSP_010888. FT VARSPLIC 894 1034 Missing (in isoform 3). FT /FTId=VSP_010889. SQ SEQUENCE 1034 AA; 117535 MW; E43DB0D8D72D954C CRC64; MALIMEPVSK WSPSQVVDWM KGLDDCLQQY IKNFEREKIS GDQLLRITHQ ELEDLGVSRI GHQELILEAV DLLCALNYGL ETENLKTLSH KLNASAKNLQ NFITGRRRSG HYDGRTSRKL PNDFLTSVVD LIGAAKSLLA WLDRSPFAAV TDYSVTRNNV IQLCLELTTI VQQDCTVYET ENKILHVCKT LSGVCDHIIS LSSDPLVSQS AHLEVIQLAN IKPSEGLGMY IKSTYDGLHV ITGTTENSPA DRCKKIHAGD EVIQVNHQTV VGWQLKNLVN ALREDPSGVI LTLKKRPQSM LTSAPALLKN MRWKPLALQP LIPRSPTSSV ATPSSTISTP TKRDSSALQD LYIPPPPAEP YIPRDEKGNL PCEDLRGHMV GKPVHKGSES PNSFLDQEYR KRFNIVEEDT VLYCYEYEKG RSSSQGRRES TPTYGKLRPI SMPVEYNWVG DYEDPNKMKR DSRRENSLLR YMSNEKIAQE EYMFQRNSKK DTGKKSKKKG DKSNSPTHYS LLPSLQMDAL RQDIMGTPVP ETTLYHTFQQ SSLQHKSKKK NKGPIAGKSK RRISCKDLGR GDCEGWLWKK KDAKSYFSQK WKKYWFVLKD ASLYWYINEE DEKAEGFISL PEFKIDRASE CRKKYAFKAC HPKIKSFYFA AEHLDDMNRW LNRINMLTAG YAERERIKQE QDYWSESDKE EADTPSTPKQ DSPPPPYDTY PRPPSMSCAS PYVEAKHSRL SSTETSQSQS SHEEFRQEVT GSSAVSPIRK TASQRRSWQD LIETPLTSSG LHYLQTLPLE DSVFSDSAAI SPEHRRQSTL PTQKCHLQDH YGPYPLAESE RMQVLNGNGG KPRSFTLPRD SGFNHCCLNA PVSACDPQDD VQPPEVEEEE EEEEEEGEAA GENIGEKSES REEKLGDSLQ DLYRALEQAS LSPLGEHRIS TKMEYKLSFI KRCNDPVMNE KLHRLRILKS TLKAREGEVA IIDKVLDNPD LTSKEFQQWK QMYLDLFLDI CQNTTSNDPL SISSEVDVIT SSLAHTHSYI ETHV //