ID GAB3_HUMAN Reviewed; 586 AA. AC Q8WWW8; A6NHF8; E9PB44; DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 03-SEP-2014, entry version 87. DE RecName: Full=GRB2-associated-binding protein 3; DE AltName: Full=GRB2-associated binder 3; DE AltName: Full=Growth factor receptor bound protein 2-associated protein 3; GN Name=GAB3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Dendritic cell, and Eosinophil; RX PubMed=11739737; DOI=10.1128/MCB.22.1.231-244.2002; RA Wolf I., Jenkins B.J., Liu Y., Seiffert M., Custodio J.M., Young P., RA Rohrschneider L.R.; RT "Gab3, a new DOS/Gab family member, facilitates macrophage RT differentiation."; RL Mol. Cell. Biol. 22:231-244(2002). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Thalamus, and Trachea; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., RA Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., RA Jones M.C., Hurles M.E., Andrews T.D., Scott C.E., Searle S., RA Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., RA Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., RA Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., RA Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., RA Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., RA Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., RA Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., RA Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., RA Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., RA Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., RA Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., RA Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., RA Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., RA Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., RA Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., RA Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., RA Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., RA Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., RA Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., RA Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., RA Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., RA de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., RA Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., RA Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., RA Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., RA Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., RA Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., RA Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., RA Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., RA Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., RA Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., RA Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., RA Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., RA Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., RA Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., RA Williams G., Williams L., Williamson A., Williamson H., Wilming L., RA Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., RA Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., RA Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., RA Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., RA Gibbs R.A., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Interacts with PIK3R/p85, SHP2 and GRAP2/MONA (By CC similarity). May interact with Grb2. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8WWW8-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8WWW8-2; Sequence=VSP_045033; CC Note=No experimental confirmation available; CC Name=3; CC IsoId=Q8WWW8-3; Sequence=VSP_045033, VSP_055259; CC Note=No experimental confirmation available; CC -!- PTM: Phosphorylated on tyrosine residue(s) after macrophage CC colony-stimulating factor (M-CSF) receptor stimulation (By CC similarity). CC -!- SIMILARITY: Belongs to the GAB family. CC -!- SIMILARITY: Contains 1 PH domain. CC -!- SEQUENCE CAUTION: CC Sequence=AK307927; Type=Erroneous termination; Positions=587; Note=Translated as stop; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY057989; AAL25825.1; -; mRNA. DR EMBL; AK126283; BAG54302.1; -; mRNA. DR EMBL; AK307927; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC107450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC109993; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471172; EAW72665.1; -; Genomic_DNA. DR EMBL; CH471172; EAW72667.1; -; Genomic_DNA. DR CCDS; CCDS14760.1; -. [Q8WWW8-1] DR CCDS; CCDS48198.1; -. [Q8WWW8-2] DR RefSeq; NP_001075042.1; NM_001081573.2. [Q8WWW8-2] DR RefSeq; NP_001269212.1; NM_001282283.1. DR RefSeq; NP_542179.1; NM_080612.3. [Q8WWW8-1] DR RefSeq; XP_005274705.1; XM_005274648.1. [Q8WWW8-2] DR RefSeq; XP_006724867.1; XM_006724804.1. [Q8WWW8-2] DR UniGene; Hs.496982; -. DR ProteinModelPortal; Q8WWW8; -. DR SMR; Q8WWW8; 26-109. DR BioGrid; 126581; 7. DR IntAct; Q8WWW8; 1. DR MINT; MINT-1594309; -. DR STRING; 9606.ENSP00000399588; -. DR PhosphoSite; Q8WWW8; -. DR DMDM; 74716251; -. DR PaxDb; Q8WWW8; -. DR PRIDE; Q8WWW8; -. DR DNASU; 139716; -. DR Ensembl; ENST00000369568; ENSP00000358581; ENSG00000160219. DR Ensembl; ENST00000369575; ENSP00000358588; ENSG00000160219. [Q8WWW8-1] DR Ensembl; ENST00000424127; ENSP00000399588; ENSG00000160219. [Q8WWW8-2] DR Ensembl; ENST00000593794; ENSP00000470124; ENSG00000268699. [Q8WWW8-2] DR Ensembl; ENST00000596917; ENSP00000468967; ENSG00000268699. [Q8WWW8-1] DR GeneID; 139716; -. DR KEGG; hsa:139716; -. DR UCSC; uc004fmj.1; human. [Q8WWW8-1] DR CTD; 139716; -. DR GeneCards; GC0XM153903; -. DR HGNC; HGNC:17515; GAB3. DR HPA; HPA010090; -. DR MIM; 300482; gene. DR neXtProt; NX_Q8WWW8; -. DR PharmGKB; PA28479; -. DR eggNOG; NOG68199; -. DR HOGENOM; HOG000236270; -. DR HOVERGEN; HBG107126; -. DR InParanoid; Q8WWW8; -. DR OMA; EFQNNFV; -. DR PhylomeDB; Q8WWW8; -. DR TreeFam; TF329487; -. DR ChiTaRS; GAB3; human. DR GenomeRNAi; 139716; -. DR NextBio; 35462577; -. DR PRO; PR:Q8WWW8; -. DR ArrayExpress; Q8WWW8; -. DR Bgee; Q8WWW8; -. DR CleanEx; HS_GAB3; -. DR Genevestigator; Q8WWW8; -. DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR001849; PH_domain. DR InterPro; IPR011993; PH_like_dom. DR Pfam; PF00169; PH; 1. DR SMART; SM00233; PH; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; KW Reference proteome. FT CHAIN 1 586 GRB2-associated-binding protein 3. FT /FTId=PRO_0000318939. FT DOMAIN 5 117 PH. FT VAR_SEQ 125 125 A -> AA (in isoform 2 and isoform 3). FT /FTId=VSP_045033. FT VAR_SEQ 510 548 Missing (in isoform 3). FT /FTId=VSP_055259. FT VARIANT 237 237 P -> S (in dbSNP:rs17281349). FT /FTId=VAR_038917. SQ SEQUENCE 586 AA; 65589 MW; 9DE0223C34AD8FFE CRC64; MSAGDAVCTG WLVKSPPERK LQRYAWRKRW FVLRRGRMSG NPDVLEYYRN KHSSKPIRVI DLSECAVWKH VGPSFVRKEF QNNFVFIVKT TSRTFYLVAK TEQEMQVWVH SISQVCNLGH LEDGADSMES LSYTPSSLQP SSASSLLTAH AASSSLPRDD PNTNAVATEE TRSESELLFL PDYLVLSNCE TGRLHHTSLP TRCDSWSNSD RSLEQASFDD VFVDCLQPLP SSHLVHPSCH GSGAQEVPSS RPQAALIWSR EINGPPRDHL SSSPLLESSL SSTIQVDKNQ GSLPCGAKEL DIMSNTPPPR PPKPSHLSER RQEEWSTHSG SKKPECTLVP RRISLSGLDN MRTWKADVEG QSLRHRDKRL SLNLPCRFSP MYPTASASIE DSYVPMSPQA GASGLGPHCS PDDYIPMNSG SISSPLPELP ANLEPPPVNR DLKPQRKSRP PPLDLRNLSI IREHASLTRT RTVPCSRTSF LSPERNGINS ARFFANPVSR EDEESYIEME EHRTASSLSS GALTWTKKFS LDYLALDFNS ASPAPMQQKL LLSEEQRVDY VQVDEQKTQA LQSTKQEWTD ERQSKV //